Neoadjuvant Radiochemotherapy and Radical Resection for Advanced Squamous Cell Carcinoma of the Oral Cavity

Eich, Hans Theodor; Löschcke, Michael; Scheer, Martin; Köcher, Martin; Bongartz, Rudolf; Wacker, Sidonie; Zöller, Joachim E.; Müller, Rolf-Peter

doi:10.1007/s00066-008-1725-6

Cited by 45 publications

(31 citation statements)

References 35 publications

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“…Our results indicate that primary surgery followed by adjuvant radiochemotherapy is suboptimal for patients with a UICC stage IVb OSCC [31]. During the last 10 years, a few studies evaluating the effect of neoadjuvant RCT in OSCC have been published but none has addressed the issue of possible differences between patients of the UICC stages IVa and IVb [18,22,26,28,32,33].…”

Section: Discussionmentioning

confidence: 78%

“…Approximately 80-90% of patients with stage I oral squamous cell carcinoma (OSCC) are cured with surgery or radiotherapy (RT) alone, outcome for patients with advanced stage tumors, however, remains poor, yielding 5-year survival rates from 45-53% [15,22,42]. Locoregional recurrences and distant metastases are frequent after surgical resection of advanced stage OSCC [7].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the inclusion criteria that define high-risk tumors vary between the different studies [6]. Several studies have examined the effects of neoadjuvant RCT followed by radical surgery on OSCC [19,22,26,33,39]. To the best of our knowledge, there is only one study that compared the results of adjuvant RT and RCT in advanced tongue carcinoma but no study that focuses on the effects adjuvant RCT in patients with squamous cell carcinoma from all sites of the oral cavity excluding tumors from other sites of the head and neck region [24].…”

Section: Introductionmentioning

confidence: 99%

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Combined-modality treatment in advanced oral squamous cell carcinoma

et al. 2011

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined-modality treatment in advanced oral squamous cell carcinoma

et al. 2011

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“…The site of the primary may influence the rate of DM, with reported ~ 75-80% 2-3y DM-free survival rates in localregionally advanced nasopharyngeal [16,18,21,29], sinonasal [9,13,22], hypopharyngeal [27] and laryngeal tumors [5], ~ 85-95% in oropharyngeal tumors [4,7,15], and ~ 90-95% in oral cavity cancer (OCC) [3][4][5][6]10], respectively. For local-regionally advanced hypopharyngeal tumors, 3y-DM free survival rates of as low as 30% are reported [8,17].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Distant Metastasis in Head Neck Cancer Patients: Implications for Induction Chemotherapy and Pre-treatment Staging?

2008

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Background and Purpose: Intensity modulated radiation therapy (IMRT) combined treatment approaches, surgical and radiodiagnostic advances, respectively, lead to improved local-regional control in head neck cancer (HNC). With increasing local-regional control, distant metastases (DM) become more meaningful. In some trials without concomitant chemotherapy, induction chemotherapy (IC) resulted in an absolute reduction of DM by ~10-15%. In order to define a more efficient selection of patients at risk for DM with respect to IC and M-staging, we analysed our patients treated by contemporary standards. Patients and Methods: Between 1/2002 to 12/2007, 409 HNC patients were treated with IMRT; 303/409 (74%) underwent definitive, 106 (26%) postoperative IMRT. The mean/median follow-up was 23/20 months (3-72). 70% tolerated 4-7, 9% 1-3 cycles of simultaneous cisplatin. Treatment followed a prospectively designed protocol. In a previous study with 172 HNC IMRT patients, gross tumor volume (GTV) was found the strongest predictor for local-regional control. In the current study, this criterion has been prospectively tested for DM. Numbers needed to treat were calculated for IC. Results: DM developed in 28/399 (7%) patients; 10 presented initially with DM (total 38/409). In 13/28 (46%), DM remained the only manifestation of disease. GTV was the strongest predictor for DM (p < 0.0001) of all tested. Only 4% of patients with GTV < 70 cc developed DM, vs. 25% (18/73) with > 70 cc; only 6 of them (6/73, 8%) developed isolated DM. Conclusion: GTV was the most significant predictor for DM, that could guide selective pre-treatment M-staging. The subgroup with isolated DM in the high risk group, that could benefit from IC, is small. (Table 1). Die Therapie folgte einem prospektiv festgelegten Protokoll. In einer früheren Studie mit 172 KHTPatienten mit definitiver IMRT wurde das "gross tumor volume" (GTV) als signifikantester Prädiktor für die Lokoregionalkontrolle nachgewiesen. In der hier präsentierten Studie wurde dasselbe volumetrische Staging-System getestet hinsichtlich dessen prä-diktiven Wert für DM, um eine allfällige IC wie auch die initiale Metastasensuche selektiver auf ein Hochrisikopatientensegment beschränken zu können. Ergebnisse: DM fanden sich bei 38/409 Patienten bzw. bei 28/399 mit initialem M0-Status (7%) (Abbildung 1, Tabelle 2); 10 Patienten hatten initial bereits DM. Bei nur 13/28 (46%) blieben DM die einzige Krankheitsmanifestation. Das GTV erwies sich als signifikantester aller getesteter Metastasenprädiktoren (p < 0,0001, Abbildung 2, Tabelle 3); nur 4% der Patienten mit einem GTV < 70 cc entwickelten DM, vs. 25% (18/73) mit GTV > 70 cc, von diesen nur 6 mit isolierter DM (6/73, 8%). IntroductionClinical implementation of intensity modulated radiation therapy (IMRT), together with combined treatment approaches in definitive and postoperative treatment settings, surgical and radio-diagnostic advances, respectively, lead to an encouraging improvement of the loco-regional control in head and neck cancer (HNC)...

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“…The current study indicated that ABCG2 and podoplanin positive cancer cells in vitro shows highly correlated with the growth, metastasis and recurrence of cancer cells [7][8][9] . Increasing evidence suggests that the expression of ABCG2 and podoplanin in oral lichen planus and oral erythroplakia were sighifi cantly associated with the risk of malignant transformation 10,11) . However, there is a little evidence for the location and distribution of ABCG2 and podoplanin in OSCC tissues and corresponding cervical lymph node.…”

Section: Introductionmentioning

confidence: 99%

Cytoplasmic ABCG2 and Podoplanin Expression in Oral Squamous Cell Carcinoma Correlates with Lymph Node Metastasis

Liu

Xia

Zhu

et al. 2017

J. Hard Tissue Biology.

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The cervical lymph node metastasis of Oral Squamous Cell Carcinoma (OSCC) has been considered to be the main causes of death. The aim of our study was to clarify the expression pattern of ABCG2 and podoplanin in OSCC tissues and corresponding cervical lymph node, and evaluate the diagnostic value of ABCG2 and podoplanin in OSCC for tumorigenesis, histological stage and clinical prognosis. ABCG2 showed a mixed membranous and cytoplasmic pattern of staining in specifi c regions of stratum corneum and the center of well diff erentiated cancer nest, while only expressed in cytoplasm of poorly differentiated tumor nests. Podoplanin showed strong staining in LV endothelia, the periphery of well diff erentiated cancer nests, and tumor stromal fi broblasts surrounding tumor nests. The expression of ABCG2, especially cytoplasmic ABCG2, and podoplanin protein showed signifi cantly higher tendency to lymph node metastasis (P<0.05). Meanwhile, podoplanin positive rate increased with the decreasing degree of histological diff erentiation (P<0.05). ABCG2 and podoplanin expression pattern is correlated with lymph node metastasis of OSCC. This result suggested that cytoplasmic ABCG2 with podoplanin have clinical potential in reliable molecule diagonsis for OSCC.

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Neoadjuvant Radiochemotherapy and Radical Resection for Advanced Squamous Cell Carcinoma of the Oral Cavity

Abstract: Neoadjuvant radiochemotherapy with subsequent radical surgery can be recommended as an effective and safe treatment for primary resectable advanced tumors of the oral cavity. Acute and long-term toxicities appear to be moderate.

Cited by 45 publications

References 35 publications

Combined-modality treatment in advanced oral squamous cell carcinoma

Combined-modality treatment in advanced oral squamous cell carcinoma

Prediction of Distant Metastasis in Head Neck Cancer Patients: Implications for Induction Chemotherapy and Pre-treatment Staging?

Cytoplasmic ABCG2 and Podoplanin Expression in Oral Squamous Cell Carcinoma Correlates with Lymph Node Metastasis

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