Histological Investigations of <i>Toxocora Canis Tissues</i> and their Micromorphological Changes Under the Action ofAlbendazole <i>in vivo</i>

Aukštikalnienė, Rasa; Kublickienė, Ona; Vyšniauskas, Antanas; Žilinskienė, Rita

doi:10.1080/13921657.2000.10512329

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…The data of histological investigations of the body cover of controls T. canis (normal fresh and solvent controls) were similar to that described by Aukštikalniene et al (2000). Moreover, Bogojavlenskij et al (1982) presented similar microstructure of the cuticle, hypodermis, and muscle cells in various nematode species.…”

Section: Discussionsupporting

confidence: 66%

“…However, the earlier onset of those changes was recorded with the former. Indeed, Aukštikalniene et al (2000) presented the histological changes of T. canis tissues under in vivo action of albendazole (ABZ) similar to that were described in the present work after in vitro administration of ABZ-SO. According to their data, the most significant changes in the eliminated T. canis nematodes had been observed on the body cover within 32-33 h onset the treatment with ABZ.…”

Section: Discussionsupporting

confidence: 55%

“…The results were compared with those observed in the worm cuticle following incubation in albendazole (Vermizole®, Amoun Phamaceutical Co., Egypt); as it was 100% effective against adult T. canis (Aukštikalniene et al 2000).…”

Section: Introductionmentioning

confidence: 99%

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Comparative in vitro effect of artemether and albendazole on adult Toxocara canis

Shalaby¹,

Abdel-Shafy²,

Abdelrahman³

et al. 2009

Parasitol Res

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Since the integrity of Toxocara canis cuticle is essential for the nutritive and protective functions, light and scanning electron microscopic studies were undertaken to assess, for the first time, whether artemether had any effect on the cuticle including lips and sensory organs following 24 and 48 h incubation in vitro. The results were compared with those observed in the worm cuticle following incubation in albendazole, as it was 100% effective against adult nematode. The body cover changes seen after in vitro administration of artemether were similar to that induced by albendazole sulfoxide, active form, (ABZ-SO). However, the earlier onset of those changes was recorded with the former. The swollen appearance of the anterior end of T. canis, including the lips, distortion of some sensory papillae, and appearance of a number of lesions on the lips, were observed during in vitro action of artemether. Cuticular disruption had also been observed in adult T canis exposed to ABZ-SO. The surface changes were more severe than those observed following incubation in artemether, with which limited loss of the cuticle occurred in the lips of nematode but was not as widespread as that seen with ABZ-SO. However, the cuticular swelling of the anterior end of T canis was more pronounced than that with ABZ-SO. In the present study, artemether presented itself as a drug that might become important in nematode chemotherapy, besides its broad spectrum of activity against various trematodes.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 55%

See 1 more Smart Citation

Comparative in vitro effect of artemether and albendazole on adult Toxocara canis

Shalaby¹,

Abdel-Shafy²,

Abdelrahman³

et al. 2009

Parasitol Res

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“…Albendazole is a new benzimidazole derivative, with a fast intestinal absorption and it is used for the control of intestinal roundworms (Escobedo et al, 1987;Rahemtulla et al, 1987;Vyðniauskas et al, 1998). There are some data about this drug joining the tubulin of ascarids in vitro (Barrowman et al, 1984) and about the micromorphological changes of T. canis tissues after the treatment with albendazole in vivo (Aukðtikalnienë et al, 2000). However, information concerning the influence of pyrantel pamoate and albendazole on glycogen deposits in the tissues of T. canis was not available for us.…”

Section: Introductionmentioning

confidence: 96%

Histochemical Investigations of Glycogen Deposits in the Tissues of Toxcora Canis and their changes after the Influence of Pyrantel Pamoate and Albendazole in vivo

Aukštikalnienė

Kublickienė

2000

Acta Zoologica Lituanica

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There were investigated the glycogen deposits in Toxocara canis tissues in norm and after the treatment with pyrantel pamoate and albendazole in vivo. Two trials with 8 and 5 puppies in each were applied. Trial 1 was given a recommended single therapeutic 14.4 mg/kg dose of pyrantel pamoate. Trial 2 was given a recommended single therapeutic 30 mg/kg dose of albendazole. Drugs were fed to each puppy individually. Two infected puppies were left untreated as controls. T. canis, eliminated from the host intestine, were quickly collected and prepared for histochemical examination (PAS reaction). Histochemical examination was carried out on the helminths eliminated from the host intestine 8, 12, 24 and 36 hours after the treatment with pyrantel pamoate and 19-21, 32-33, 37-38, 46, and 54 hours after the treatment with albendazole. A distinct positive PAS reaction of hypodermis, muscle cells, epithelial cells of intestine, epithelial cells of sexual tubes and of eggs was observed in the control T. canis. Both used anthelmintics at first decreased glycogen deposits in the epithelial cells of intestine of T. canis. Pyrantel pamoate acts on glycogen deposits in the muscle cells of T. canis stronger than albendazole. There has been observed a negative PAS reaction of these cells of T. canis 36 hours after the treatment with pyrantel pamoate. Then after the treatment with albendazole, a negative PAS reaction in the muscle cells was established only in the helminths that were eliminated from the host intestine in 54 hours. Lateral cords and hypodermis of T. canis show a weak PAS reaction 21 hour after their treatment with albendazole, whereas after the treatment with pyrantel pamoate and even 24 hours afterwards, these tissues show a distinct positive PAS reaction. It is interesting to note that sexual tubes and sexual products show a positive PAS reaction up to the end of the experiment with pyrantel pamoate (36th hour). Also, after the treatment with albendazole, sexual tubes show a distinct positive PAS reaction on the 37-38 hour, while a negative PAS reaction of these organs was established only on the 46th hour of the experiment with albendazole. It might be concluded that pyrantel pamoate and albendazole affect the amount of reserve carbohydrate glycogen in the tissues of T. canis and cause its decrease and disappearance.

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Reduced Fitness in Adults From Larval,Galleria mellonella(Lepidoptera: Pyralidae) Reared on Media Amended With the Antihelmintic, Mebendazole

Çalık¹,

Büyükgüzel²,

Büyükgüzel³

2015

J Econ Entomol

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Benzimidazole antihelmintics, including mebendazole, have a broad antiparasitic spectrum. These drugs play a major role in the treatments of parasites of intestines or other organs of vertebrates, humans, and other animals.The impact of mebendazole on the biology of the greater wax moth, Galleria mellonella (L.), was assessed by observation of several developmental parameters as follows: survivorship, developmental time, and adult longevity. Sublethal toxicity was measured through reproductive parameters such as fecundity and hatchability.The larvae were reared on artificial diet from first-instar larvae to the adult stage in the laboratory. The diets contained mebendazole at different concentrations of 0.005, 0.05, 0.5, or 1.0%. Control diet did not containme bendazole and produced seventh-instar larvae in 96.6±1.67% of cases, whereas the addition of mebendazole into diet at 1.0% significantly decreased survivorship of seventh-instar larvae to 79.9±4.08%. The diet with the highest concentration of mebendazole decreased survivorship in the adult stage from 79.9±2.35 to 56.6±4.73%, and shortened the developmental time for adult emergence from 36.7±0.48 to 34.1±0.63 d. All mebendazole concentrations shortened adult longevity and significantly decreased fecundity and hatch ability of G. mellonella. The highest dietary concentration of this antihelmintic significantly decreased the egg number to 28.6±2.89 and hatching rate to 51.7±1.85%. The present study demonstrates that mebendazole exhibits significant adverse effects on greater wax moth, leading to deteriorated life table parameters and decreased adult fitness.

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Histological Investigations of Toxocora Canis Tissues and their Micromorphological Changes Under the Action ofAlbendazole in vivo

Cited by 3 publications

References 7 publications

Comparative in vitro effect of artemether and albendazole on adult Toxocara canis

Comparative in vitro effect of artemether and albendazole on adult Toxocara canis

Histochemical Investigations of Glycogen Deposits in the Tissues of Toxcora Canis and their changes after the Influence of Pyrantel Pamoate and Albendazole in vivo

Reduced Fitness in Adults From Larval,Galleria mellonella(Lepidoptera: Pyralidae) Reared on Media Amended With the Antihelmintic, Mebendazole

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