Histological Study of the Effect of Ethanolic Leaf Extract of Sida Acuta on the Cerebral Cortex of Adult Wistar Rats

Ofem, P. S; Asuquo, Olaitan R.; Akpantah, Amabe O.; Ekanem, Theresa B.

doi:10.9790/0853-0856063

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…This study reveals degeneration of the pyramidal cells of the hippocampus in group 2 ( Figure 2) administered with 200 mg/kg body weight of Sida acuta compared with that of the control (Figure 1) that showed the normal cytoarchitecture of the hippocampus. This finding agrees with that reported by Eluwa et al that Sida acuta has a degenerative effect on the cells of the central nervous system [12]. This micro-anatomical alteration observed in the pyramidal layer of the CA3 of the hippocampus has the ability to tamper with the normal functioning of the CA3 relative to the memory function of the hippocampus.…”

Section: Discussionsupporting

confidence: 92%

“…Extraction was carried out by separately macerating and sucking in commercial ethanol for extraction for about 48hours with intermittent agitation and were then filtered and left separately in the water bath to concentrate. The doses and protocols for R. vomitoria and Sida acuta extracts were as previously described by [11,12] respectively.…”

Section: Extracts Preparationmentioning

confidence: 99%

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Neurohistological Study of the Interactive Influence of Ethanolic Leaf Extracts of Sida acuta and Rauvolfia vomitoria on the Hippocampus of Albino Rats

Okon

Bassey

Edet

et al. 2020

JOCAMR

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Aim: To provide information on the interactive influence of Sida acuta and Rauvolfia vomitoria on the hippocampus of albino rats using neurohistological parameter. Methods: Thirty-five (35) female adult albino rats were used for the experiment. They were randomly divided into seven groups of five animals in each group. Group 1: The control group was given feed and water ad libitum for 28 days. Groups 2-7 served as the experimental groups. Group 2: Received 200 mg/kg body weight of Sida acuta leaf extract for 14 days. Group 3: Received 212.5 mg/kg body weight of Rauvolfia vomitoria leaf extract for 14 days. Group 4: Received 200 mg/kg body weight of Sida acuta and 212.5 mg/kg body weight of Rauvolfia vomitoria leaf extract for 14 days. Group 5: Received 200 mg/kg body weight of Sida acuta leaf extract for 14 days, then 212.5 mg/kg body weight of Rauvolfia vomitoria for the remaining 14 days. Group 6: Received 400 mg/kg body weight of Sida acuta leaf extract for 14 days, then 425 mg/kg body weight of Rauvolfia vomitoria for the remaining 14 days. Group 7: Received 600 mg/kg body weight of Sida acuta leaf extract for 14 days, then 850 mg/kg body weight of Rauvolfia vomitoria for the remaining 14 days. Results: Sida acuta at the tested dose of 200 mg/kg body weight induced degeneration of pyramidal cells when compared to the control, Rauvolfia vomitoria at the tested dose of 212.5 kg/mg body weight exhibited neuroprotective effect, co-administration of both Sida acuta at 200 mg/kg body weight and Rauvolfia vomitoria at 212.5 mg/kg body weight and administration of Rauvolfia vomitoria after Sida acuta at increasing doses significantly reverse these changes to near normal when compared to the group that received 200 mg/kg body weight of Sida acuta for 14 days. Conclusion: Rauvolfia vomitoria had the potential of ameliorating the neurodegenerative effect caused by the Sida acuta leaf extract on the pyramidal cells of the hippocampus albino rats.

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Section: Discussionsupporting

confidence: 92%

Section: Extracts Preparationmentioning

confidence: 99%

Neurohistological Study of the Interactive Influence of Ethanolic Leaf Extracts of Sida acuta and Rauvolfia vomitoria on the Hippocampus of Albino Rats

Okon

Bassey

Edet

et al. 2020

JOCAMR

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“…Leaf and root Juice Alkaloids, phytosterols, tannins, flavonoids saponins, Leaf decoction is used to clean the wound root juice applied on the wound ↑tensile strength, quicker epithelialization, and wound contraction rate [35,36] .…”

Section: Sida Acuta (Malvaceae)mentioning

confidence: 99%

Review of selected herbal phytoconstituents for wound healing treatment

Landge

2024

J Pharmacogn Phytochem

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Wounds are an unavoidable part of life that can come through physical accidents that cause an opening or break in the skin, as well as chemical sources. Many invading organisms find the wound region to be an appropriate medium for manipulation. As a result, invasive microbial diseases can still invade the wounded skin. Wound healing is a complex process of tissue repair and remodelling that happens in the following of an injury. As a result, wound care's primary purpose is to prevent or reduce infection while also promoting healing. Antibacterial medicines, among other materials and procedures, are used. Phytochemicals are well-known for their ability to treat a variety of diseases and conditions. It also has a lot of potential for discovering and developing new medications for a variety of human illnesses. Plants and plant-derived elements have long been used to treat and manage many types of wounds. Plants and plant-derived elements have long been used to treat and manage many types of wounds. The purpose of this review is to compile a list of medicinal plants and phytoconstituents that have been shown to be beneficial in the treatment of wounds.

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“…In S. acuta , leaf and stem extracts have anticonvulsant effects on pentylene tetrazole (PTZ)- induced seizures in mice [ 189 ]. Ethanolic extract of leaf of S. acuta showed neuroprotective effect in cerebral cells of experimental rats [ 239 ].…”

Section: Ethnopharmacological Activitiesmentioning

confidence: 99%

Ethnomedicinal, Phytochemical and Ethnopharmacological Aspects of Four Medicinal Plants of Malvaceae Used in Indian Traditional Medicines: A Review

Abat¹,

Kumar

Mohanty³

2017

Medicines

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The ethnomedicinal values of plants form the basis of the herbal drug industry. India has contributed its knowledge of traditional system medicines (Ayurveda and Siddha) to develop herbal medicines with negligible side effects. The World Health Organization has also recognized the benefits of drugs developed from natural products. Abutilon indicum, Hibiscus sabdariffa, Sida acuta and Sida rhombifolia are ethnomedicinal plants of Malvaceae, commonly used in Indian traditional system of medicines. Traditionally these plants were used in the form of extracts/powder/paste by tribal populations of India for treating common ailments like cough and cold, fever, stomach, kidney and liver disorders, pains, inflammations, wounds, etc. The present review is an overview of phytochemistry and ethnopharmacological studies that support many of the traditional ethnomedicinal uses of these plants. Many phytoconstituents have been isolated from the four ethnomedicinal plants and some of them have shown pharmacological activities that have been demonstrated by in vivo and/or in vitro experiments. Ethnomedicinal uses, supported by scientific evidences is essential for ensuring safe and effective utilization of herbal medicines.

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Histological Study of the Effect of Ethanolic Leaf Extract of Sida Acuta on the Cerebral Cortex of Adult Wistar Rats

Cited by 7 publications

References 11 publications

Neurohistological Study of the Interactive Influence of Ethanolic Leaf Extracts of Sida acuta and Rauvolfia vomitoria on the Hippocampus of Albino Rats

Neurohistological Study of the Interactive Influence of Ethanolic Leaf Extracts of Sida acuta and Rauvolfia vomitoria on the Hippocampus of Albino Rats

Review of selected herbal phytoconstituents for wound healing treatment

Ethnomedicinal, Phytochemical and Ethnopharmacological Aspects of Four Medicinal Plants of Malvaceae Used in Indian Traditional Medicines: A Review

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