Histological Study on the Effect of Experimentally Induced Hyperthyroidism on Testes of Adult Albino Rats and Possible Ameliorating Role of L-carnitine

Hegazy, Abdelmonem Awad; Morsy, Manal Mohammad; Moawad, Rania Said; El-Sayed, G

doi:10.21608/ejh.2019.13060.1121

Cited by 1 publication

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“…Examination of Mallory's trichrome stained sections revealed that deposition of collagen fibers significantly increased in the connective tissue septa around the pancreatic acini, ducts and blood vessels of the hyperthyroid group. This was in accordance with Meligy et al (24) who examined the liver of hyperthyroid rats and observed significant increase in the collagen deposition and Hegazy et al (25) who found that hyperthyroidism accompanied with marked thickness in the capsule of the testes indicating that the collagen fibers deposition increased in the capsule as well as around the blood vessels. Safadi and Friedman (26) explained the increase of liver fibrosis that it might resulted from activation of stellate cells by ROS and subsequent increase in collagen synthesis and fibrogenesis.…”

Section: Discussionsupporting

confidence: 89%

Effect of Induced Hyperthyroidism on Pancreas of Adult Female Albino Rats

Alazouny¹,

Ibrahim²,

Elmaksoud³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Introduction: A condition known as hyperthyroidism can lead to a wide range of health issues, including osteoporosis, oxidative liver damage, diabetes mellitus, as well as cardiovascular disease. Objective: To examine the detrimental effects of hyperthyroidism on the pancreatic structure of adult female albino rats. Materials and Methods: twenty-one adult virgin female albino rats were assigned to 2 groups; control and induction of hyperthyroidism. Serological analysis to assess thyroid functions, oxidative stress and lipid peroxidation analysis was carried out. Pancreatic samples were processed for light microscopic examination. Results: Hyperthyroidism caused both biochemical and histological changes on pancreas of adult female albino rats. The biochemical changes in the form of significant decreased in the thyroid stimulating hormone serum level, significant reduction in level of serum superoxide dismutase and the malondialdehyde level was significantly increased in the hyperthyroid rats. The histological changes were loss of its general architecture. The pancreatic acini appeared irregular, vacuolated and had dark nuclei. Some islets of Langerhans appeared shrunken and the acini did not have the normal smooth demarcation from the surface. Conclusion: Hyperthyroidism seriously affected the histological structure of the pancreas with subsequent disturbance in the biochemical markers.

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Section: Discussionsupporting

confidence: 89%