Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue

Salvatore, Stefano; Maggiore, Umberto Leone Roberti; Athanasiou, Stavros; Origoni, Massimo; Candiani, Massimo; Calligaro, Alberto; Zerbinati, Nicola

doi:10.1097/gme.0000000000000401

Cited by 222 publications

(187 citation statements)

References 16 publications

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“…Recent short-term studies with limited numbers of subjects have suggested that laser therapy may result in remodelling of vaginal connective tissue and thickening and improved glycogen storage of the vaginal epithelium in women with vaginal atrophy [49,50]. Improvement in VVA symptoms (vaginal dryness, burning, itching and dyspareunia) and vaginal health index scores [51,52], have been reported but long term studies are required.…”

Section: Lasermentioning

confidence: 97%

Update on management of genitourinary syndrome of menopause: A practical guide

et al. 2015

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Section: Lasermentioning

confidence: 97%

Update on management of genitourinary syndrome of menopause: A practical guide

et al. 2015

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“…Salvatore et al analyzed ex vivo vaginal specimens from postmenopausal women and observed tissue remodeling without damage to surrounding tissue, after the application of fractional CO 2 laser technology (Salvatore et al, 2015a, Salvatore et al, 2015b). A subsequent study assessing the efficacy of microabalative fractional CO2 laser in treating sexually active menopausal patients who had dyspareunia related to vulvovaginal atrophy showed significant improvement reported at 12-week follow-up (Salvatore et al, 2014).…”

Section: Laser-based Devices For Vaginal Rejuvenationmentioning

confidence: 99%

Vaginal rejuvenation using energy-based devices

Karcher

Sadick

2016

International Journal of Women's Dermatology

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Physiologic changes in a woman’s life, such as childbirth, weight fluctuations, and hormonal changes due to aging and menopause, may alter the laxity of the vaginal canal, damage the pelvic floor, and devitalize the mucosal tone of the vaginal wall. These events often lead to the development of genitourinary conditions such as stress urinary incontinence; vaginal atrophy; dryness; and physiologic distress affecting a woman’s quality of life, self-confidence, and sexuality. Various treatment modalities are currently available to manage these indications, varying from invasive vaginal surgery to more benign treatments like topical vaginal hormonal gels or hormone-replacement therapy. A new trend gaining momentum is the advent of energy-based devices for vaginal rejuvenation that apply thermal or nonthermal energy to the various layers of the vaginal tissue, stimulating collagen regeneration contracture of elastin fibers, neovascularization, and improved vaginal lubrication. This review aims to present the available technologies offering vaginal rejuvenation and the scientific evidence that underlines their safety and efficacy for this indication.

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“…Overall, the resulting light-induced eutrophication process involves early thermal damage (within 48 – 72 h of treatment), which is followed by a proliferation phase, with production of collagen and extracellular matrix (in the subsequent 30 days). Lastly, the remodelling phase (after 40 days) involves the apposition of mature collagen fibres and new elastic fibres [15]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the CO<sub>2</sub> Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

Pagano¹,

Gieri²,

Nocera³

et al. 2017

JCT

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Objective To evaluate the impact of fractionated CO2 laser therapy on vaginal atrophy and mild/moderate stress urinary incontinence (SUI) symptoms in patients with physiological or surgically-induced menopause. Materials and Methods Post-menopausal patients (n = 33) presenting vaginal atrophy and/or SUI, underwent three vaginal CO2 laser treatment sessions, performed at 1-month intervals. Vaginal symptoms were evaluated using the Vaginal Health Index Score (VHI-S), Visual Analogue Scales (VAS) for dyspareunia and global patient satisfaction. The impact of urinary incontinence on patient quality of life was evaluated using the International Consultation on Incontinence Questionnaire (ICIQ). Symptoms were evaluated before treatment and at every subsequent treatment session, as well as 3 months following the last treatment session. RESULTS The three-session treatment series led to a significant improvement in both subjective symptoms (dryness, burning, dyspareunia) and clinical signs (VHI-S) (P < 0.01). In addition, reductions in the frequency and severity of SUI symptoms (P < 0.01) were noted during the treatment period, and were maintained after for at least 3 months after completion of the treatment course. Improvements in VHI-S were significantly greater in patients with surgically-induced menopause, as compared to those with physiological menopause. The vast majority of patients (90%) were satisfied with the procedure, and reported a significant improvement in quality of life. No adverse events were recorded throughout the study period. Conclusions Fractionated CO2 laser therapy is a safe, effective and easy-to-perform treatment modality for menopause-related vaginal atrophy and SUI.

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Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue

Abstract: This study shows that microablative fractional CO2 laser can produce a remodeling of vaginal connective tissue without causing damage to surrounding tissue.

Cited by 222 publications

References 16 publications

Update on management of genitourinary syndrome of menopause: A practical guide

Update on management of genitourinary syndrome of menopause: A practical guide

Vaginal rejuvenation using energy-based devices

Evaluation of the CO<sub>2</sub> Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

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Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue

Abstract: This study shows that microablative fractional CO2 laser can produce a remodeling of vaginal connective tissue without causing damage to surrounding tissue.

Cited by 222 publications

References 16 publications

Update on management of genitourinary syndrome of menopause: A practical guide

Update on management of genitourinary syndrome of menopause: A practical guide

Vaginal rejuvenation using energy-based devices

Evaluation of the CO&lt;sub&gt;2&lt;/sub&gt; Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

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Evaluation of the CO<sub>2</sub> Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results