Histological variants of non–muscle invasive bladder cancer: Survival outcomes of radical cystectomy vs. bladder preservation therapy

Dursun, Furkan; Elshabrawy, Ahmed; Wang, Hanzhang; Wu, Shenghui; Liss, Michael A.; Kaushik, Dharam; Grosser, Daniel; Svatek, Robert S.; Mansour, Ahmed M.

doi:10.1016/j.urolonc.2022.02.004

Cited by 11 publications

(6 citation statements)

References 24 publications

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“…Among them, SCC is the most common histological type of non-UC of the bladder. SCC is more common in women, which may be associated with the predisposition of women to chronic urinary tract infections and cystitis ( 4 , 5 ). SCC of the bladder is highly malignant, with 5-year overall survival (OS) of approximately 23%.…”

Section: Discussionmentioning

confidence: 99%

“…The European Association of Urology guidelines classify non-muscle-invasive bladder cancer as a high-risk tumor and recommend RC treatment after early diagnosis ( 7 ). For the same reason, the American Urological Association and National Comprehensive Cancer Network guidelines recommend RC treatment for T1 patients with non-UC based on expert opinion ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Partial cystectomy for bladder squamous cell carcinoma with a 10-year follow-up: a case report

Yin,

Zhao,

et al. 2023

Front. Oncol.

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Squamous cell carcinoma (SCC) of the bladder is a rare malignancy of the urinary system. It is prone to invasion and metastasis in the early stage and has a poor prognosis. This case reports a 65-year-old female patient with SCC of the bladder who was free of disease recurrence and metastasis 10 years after partial cystectomy (PC) combined with left ureteral reimplantation. The treatment plan and admission of this patient were retrospectively analyzed in order to provide some reference significance for the treatment plan for the SCC of the bladder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Partial cystectomy for bladder squamous cell carcinoma with a 10-year follow-up: a case report

Yin,

Zhao,

et al. 2023

Front. Oncol.

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“…Accounting for 0.6–2% of all BCa in early series [2], MPBC exhibits an increased incidence ranging from 2.9 [6] to 7.6% [8,9] in more recent studies. However, as no consensus currently exists regarding a minimum threshold of micropapillary component to make MPBC diagnosis, the reported incidence strongly varied according to the proportion of micropapillary considered in each study.…”

Section: Evidence Synthesismentioning

confidence: 97%

“…Hence, our findings suggested that conservative management with BCG could represent an effective therapeutic strategy among T1 high-grade MPBC patients, especially among individuals with neither pure MPBC nor LVI at initial diagnosis. Similarly, Dursun et al [8] compared survival outcomes among 8920 nonmuscle-invasive variant histology patients treated with radical cystectomy versus bladder-preservation therapy from the National Cancer Database (NCDB); bladder preservation therapy included TURB, intravesical therapy, or radiation therapy. Consistent with our findings, no significant difference was recorded in 5-year OS among MPBC patients ( n = 684) treated with radical cystectomy versus bladder preservation therapy (5-year OS rates of 44 versus 53%; P = 0.1).…”

Section: Evidence Synthesismentioning

confidence: 99%

Micropapillary bladder cancer: an evolving biology

Lonati

Simeone

Suardi

et al. 2022

Current Opinion in Urology

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Purpose of reviewTo summarize a comprehensive overview of more recent evidence on micropapillary bladder cancer (MPBC), focusing on actual incidence, clinical features, therapeutic strategies, and prognosis.Recent findingsMPBC generally exhibits an aggressive behaviour compared with pure urothelial carcinoma (pUC) with advances in tumour stage and nodal and distant spread at diagnosis. Due to its rarity and presence of only small sample size and retrospective studies, no consensus currently exists regarding the most effective therapeutic strategy to be performed among nonmuscle-invasive (conservative treatment versus immediate radical cystectomy) and muscle-invasive MPBC (neoadjuvant therapy versus upfront radical cystectomy versus adjuvant chemotherapy).SummaryThe incidence of MPBC is recently increased according to latter literature, ranging from 2.9 to 7.6% of all bladder cancer. Despite its aggressive behaviour at time of presentation, more recent evidence fails to demonstrate a significant association between MPBC and worse outcomes compared with pUC when adjusted for clinical and pathological features. According to latter evidence, MPBC pathological response to NAC appears to be unsatisfactory compared with pUC patients while neoadjuvant immunotherapy with Pembrolizumab may represent an effective treatment among MPBC patients, based on PD-L1 and TMB expression.

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“…In the literature, one may often come across patient survival estimates for various combinations of preoperative characteristics in BC patients 2,[9][10][11][12] . However, it is often overlooked that one of the most important stages in this surgical intervention is the application of one of the possible methods of UD 13 .…”

Section: Introductionmentioning

confidence: 99%

Survival Analysis of Patients with Bladder Cancer after Radical Cystectomy

2024

Mitteilungen Klosterneuburg

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One of the most commonly used surgical operations among patients with bladder cancer (BC) is radical cystectomy (RC), which includes the removal of the entire bladder along with the surrounding lymph nodes and other nearby organs that are affected by malignant neoplasms. During this operation, the most important stage that has a direct impact on the further quality of life of the patient is the choice of the method of uroderivation (UD). Patients and Methods: Have been reviewed retrospectively the clinical records of 586 patients who had BC RC at the Oncourological Department of the Sverdlovsk Regional Oncological Dispensary (SROD) between December 2001 and May 2021 after RC with three methods of UD: external urine removal, internal urine removal, intestinal reservoir. Results: The direct dependence of the presence and severity of some complications after RC on the method of urine removal chosen by the oncologist surgeon were determined. The analysis of survival curves was carried out, as well as the 5- and 10-year survival rate of patients of the SROD after RC. According to the results of the analysis, it was found that the worst survival was observed in patients with external urine diversion, the best survival was found in patients with internal urine diversion (p < 0.05). Conclusions: Urinary diversion is definitely an important stage in the performance of such a surgical intervention as RC. The study revealed statistically significant differences between patient survival curves (p < 0.05) plotted for different groups of urinary diversion and differences between the medians of several types of survival for the groups considered (p < 0.05).

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Histological variants of non–muscle invasive bladder cancer: Survival outcomes of radical cystectomy vs. bladder preservation therapy

Cited by 11 publications

References 24 publications

Partial cystectomy for bladder squamous cell carcinoma with a 10-year follow-up: a case report

Partial cystectomy for bladder squamous cell carcinoma with a 10-year follow-up: a case report

Micropapillary bladder cancer: an evolving biology

Survival Analysis of Patients with Bladder Cancer after Radical Cystectomy

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