Histology and Morphology of the Brain Subarachnoid Trabeculae

Abstract

The interface between the brain and the skull consists of three fibrous tissue layers, dura mater, arachnoid, and pia mater, known as the meninges, and strands of collagen tissues connecting the arachnoid to the pia mater, known as trabeculae. The space between the arachnoid and the pia mater is filled with cerebrospinal fluid which stabilizes the shape and position of the brain during head movements or impacts. The histology and architecture of the subarachnoid space trabeculae in the brain are not well established in the literature. The only recognized fact about the trabeculae is that they are made of collagen fibers surrounded by fibroblast cells and they have pillar- and veil-like structures. In this work the histology and the architecture of the brain trabeculae were studied, via a series of in vivo and in vitro experiments using cadaveric and animal tissue. In the cadaveric study fluorescence and bright field microscopy were employed while scanning and transmission electron microscopy were used for the animal studies. The results of this study reveal that the trabeculae are collagen based type I, and their architecture is in the form of tree-shaped rods, pillars, and plates and, in some regions, they have a complex network morphology.

Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma

“…Interestingly, a microscopic examination of the brain-meningioma interface revealed proliferation of hyperplastic arachnoid trabeculae, (below the arachnoid membrane at the brainmeningioma interface) in the meningioma with a thin connective capsule (shown in Fig 1A of the study) [7]. After the study, it was reported that the arachnoid trabeculae and granulations are composed of type 1 collagen [18]. The arachnoid is composed of two layers.…”

Ex-vivo Quantification of Ovine Pia Arachnoid Complex Biomechanical Properties Under Uniaxial Tension

“…SAT consisted of pillars, columns, sheets, branched fibrils, and other complex structures with fibril diameters that varied from 0.5-3 µm [3]. Optical coherence tomography was utilized to show that SAT fiber diameter varies from 19.2-45.5 µm [27].…”

Laporan Kasus: Perdarahan Intraserebral Pada Acquired Prothrombin Complex Deficiency Onset Lambat

“…4 Rekomendasi Health Technology Assessment dan Departemen Kesehatan Republik Indonesia terhadap semua bayi yang baru lahir harus mendapatkan profilaksis 1 mg vitamin K1 dosis tunggal intramuskular. 3,5 Angka kejadian APCD pada neonatus yang tidak mendapatkan profilaksis vitamin K berkisar 1 tiap 200-400 orang. 6 Insidensi APCD onset lambat pada bayi yang mendapatkan profilaksis vitamin K1 secara oral adalah 1,4-6,4 per-100.000 sedangkan secara intramuskular 0,25-3,2 per-100.000.…”