Histology of the myenteric plexus in relation to rectal biopsy in congenital megacolon

Hofmann, Sandra; Orestano, F.

doi:10.1016/s0022-3468(67)80016-2

Cited by 17 publications

(9 citation statements)

References 0 publications

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“…The lower part, derived from the cloaca, is surrounded by condensed extra‐peritoneal connective tissue, and is generally empty in normal subjects, except during defecation. In humans, there are fewer enteric ganglia in the rectum compared with the colon and very few ganglia in the anal sphincter 4,5 …”

Section: Anatomymentioning

confidence: 99%

Pelvic floor: anatomy and function

Bharucha

2006

Neurogastroenterology Motil

191

158

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The pelvic floor is a dome-shaped striated muscular sheet that encloses the bladder, uterus, and rectum, and, together with the anal sphincters, has an important role in regulating storage and evacuation of urine and stool. This article reviews the anatomy, nerve supply, pharmacology, and functions of the anal sphincters and the pelvic floor. The internal and external anal sphincters are primarily responsible for maintaining faecal continence at rest and when continence is threatened, respectively. Defecation is a somato-visceral reflex regulated by dual nerve supply (i.e. somatic and autonomic) to the anorectum. The net effects of sympathetic and cholinergic stimulation are to increase and reduce anal resting pressure, respectively. Faecal incontinence and functional defecatory disorders may result from structural changes and/or functional disturbances in the mechanisms of faecal continence and defecation.

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Section: Anatomymentioning

confidence: 99%

Pelvic floor: anatomy and function

Bharucha

2006

Neurogastroenterology Motil

191

158

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“…As there is no consensus about the true length of the physiological hypoganglionic zone in normal adult individuals (Fig. 2) and the level of biopsy required [25–28], a preliminary cadaveric study was performed in which 35 full‐thickness sections of distal rectum were examined to establish the proximal point of transition. Each sample was a strip 60 mm in length excised from posterior rectal wall from the dentate line.…”

Section: Resultsmentioning

confidence: 99%

Clinical features’ diagnostics and treatment of Hirschsprung’s disease in adults

2010

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“…2 [16][17][18] Evidence has been presented that in normal development the submucous B~rrlsH MEDICAL JOURNAL 339 plexus arises by neuroblast migration from the myenteric plexus. '9 20 Thus agenesis of myenteric ganglia will cause absence of submucous ganglia, though absence of submucous ganglia may not necessarily indicate absence of myenteric ganglia.…”

Section: Discussionmentioning

confidence: 99%