Histomorphological Assessments of the Female Reproductive Organs of Rats under Indomethacin and Aspirin Treatments

Ekanem, AU; Garba, Sani Hyedima; ., A.G. Jankada

doi:10.3923/jpt.2008.203.212

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Vasoconstriction and vascularization in uterine tissues have been observed as side effects of the treatment of IMC. According to the findings of this study, the restriction of PGs by the IMC is believed to be the cause of vasoconstriction in uterine tissues ( Ekanem et al, 2008 ). Aside from ischemia, smooth muscle atrophy can directly result from a loss of blood flow to the muscle ( Bishop-Bailey & Warner, 2003 ).…”

Section: Discussionmentioning

confidence: 80%

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

Amir,

Yimer,

Hiew

et al. 2023

Saudi Journal of Biological Sciences

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Section: Discussionmentioning

confidence: 80%

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

Amir,

Yimer,

Hiew

et al. 2023

Saudi Journal of Biological Sciences

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Eremomastax speciosa and Eremomastax polysperma leaf fractions ameliorate the adverse effects of indomethacin in ovary and serum of treated rats

Mboso

Iwara

Maharjan

et al. 2022

Egyptian Pharmaceutical Journal

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Background and objective Eremomastax speciosa and Eremomastax polysperma plants potentially contain bioactive principles against reproductive toxicants and oxidative stress. Thus, the ameliorative action of methanol and ethyl acetate fractions of E. speciosa and E. polysperma leaves on cyclooxygenase-2 (COX-2) and oxidative-stressed states in indomethacin-induced rat tissues have been performed. Materials and methods The dried-leaf extract of E.speciosa and E. polysperma was subjected to liquid–liquid fractionation to obtain the ethyl acetate and methanol fractions. The ethyl acetate and methanol fractions were respectively administered orally to rats (200 mg/kg), 30 min, and 10 h after subcutaneous injection with indomethacin (5 mg/kg) for 4 days. The postadministration of E. speciosa and E. polysperma fractions was used to determine their effect on ovarian and serum COX-2 concentration, ovarian malondialdehyde, and ovarian nitric oxide concentrations. Results and conclusion E. speciosa and E. polysperma fractions significantly (P<0.05) increased the concentration of COX-2 in ovaries and serum compared with the group treated with indomethacin only. Malondialdehyde and nitric oxide concentrations were significantly (P<0.05) decreased in all the animal groups posttreated with plant fractions compared with indomethacin only. Histological assessment of the ovary showed proliferating ovarian follicles and mature Graafian follicles in the groups treated with the plant fractions, while the indomethacin-only group showed scanty primary follicles. These results showed that E. speciosa and E. polysperma leaf fractions mediated their protective effect on the ovaries and serum through the regulated COX-2 action and inhibited indomethacin-induced oxidative stress.

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Histomorphological Assessments of the Female Reproductive Organs of Rats under Indomethacin and Aspirin Treatments

Cited by 2 publications

References 23 publications

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

Eremomastax speciosa and Eremomastax polysperma leaf fractions ameliorate the adverse effects of indomethacin in ovary and serum of treated rats

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