Histomorphological effect of zidovudine on the testes of adult male wistar rats (rattus novegicus)

Chris-Ozoko, Lilian Ebite; Charity, Aienobe A; Ekundina, Victor O

doi:10.4103/2278-960x.118642

Cited by 5 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The impact of antiretroviral treatment on morphological indices of male reproductive organs, especially the testis, has generated interest among researchers owing to debates surrounding viral “sanctuary sites” and the blood–testis barrier (see comments in studies Azu, ). There is evidence from in vitro animal studies (Chris‐Ozoko et al., ) as well as Simian immunodeficiency virus studies (Matusali et al., ) suggesting that HAART cocktail (as used in this study) may be deposited in the semen. However, whereas seminal fluid testicular contribution is approximately 5% (with the prostate gland, seminal vesicles and Coopers glands making the bulk), it may well be likely that these organs are easily reached by any blood‐born substance as well.…”

Section: Discussionmentioning

confidence: 80%

“…While we reported that combination of vitamins C and E with HAART did result in significant decline in sperm count, an opposite effect was observed with vitamin C + HAART which preserved epididymal sperm count almost to the control values. More interestingly, spermatozoal motility were normalised in HH‐alone groups and HAART with vitamin E. It is important to note that while several factors need be considered in the evaluation of male fertility (WHO, ), sperm count and motility are essential components and hence could be a good indicator for assessment (Chris‐Ozoko, Charity, & Ekundina, ). More so, spermatozoal motility has been positively correlated with pregnancy rate (Zinaman, Brown, Selevan, & Clegg, ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of co-administration ofHypoxis hemerocallideaextract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats

et al. 2016

View full text Add to dashboard Cite

Although the successful introduction and rollout of antiretroviral therapy has impacted positively on morbidity and mortality of HIV-positive patients, its interaction with plant-based adjuvants remain sparsely investigated. We report the interaction and effects of adjuvant treatment with highly active antiretroviral therapy (HAART) and Hypoxis hemeocallidea (HH) extracts on testicular structure of rats. A total of 63 pathogen-free adult male Sprague Dawley rats were divided into nine groups and treated according to protocols. HAART cocktail predisposed to significant negative testicular parameters of sperm count, motility and seminiferous tubular epithelial height (quantitatively) (p < .03) and also altered the histomorphology of tubules with diffuse hypoplasia in seminiferous tubules. The higher dose of HH showed a better ability to mitigate the altered parameters and compares favourably with vitamin C in this protocol. While HH did not show any deleterious impact on morphometric data, its role as adjuvant did not significantly reduce the negative impact of HAART on morphometric indices especially with the lower dosage. Further investigations are warranted on the interactions between HAART and Hypoxis.

show abstract

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Effect of co-administration ofHypoxis hemerocallideaextract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The rats were divided into four groups (n=5), labeled as groups A, B, C, and D. The HAART (Chris-Ozoko et al, 2013) and MOE dosages (Villarruel-López et al, 2018) were prepared and administered once daily to the animals. Group A received water.…”

Section: Methodsmentioning

confidence: 99%

Moringa oleifera restored semen quality, hormonal profile, and testicular morphology against Highly Active Antiretroviral Therapy- induced toxicity in adult male Wistar rats

Ogunlade

Jeje

Adelakun

et al. 2022

JBRA Assisted Reproduction

View full text Add to dashboard Cite

Objective Reproductive toxicity has been greatly linked with Highly Active Antiretroviral Therapy (HAART) use. This study investigated the effects of Moringa oleifera Leaf Extract (MOE) on HAART-induced testicular toxicity in adult male Wistar rats. Methods Twenty adult male Wistar rats (150-200 g) were assigned into four groups (n=5). Group A received distilled water; Group B received (orally) 200 mg/kg BW HAART only; Group C received (orally) 200 mg/kg BW HAART and 100 mg/kg BW MOE (low dose group) and Group D received (orally) 200 mg/kg BW HAART and 300 mg/kg BW MOE. At the end of the 28-day experiment, body and testicular weights were measured; serum and testis obtained were subjected to hormone profiling, biochemical and histological studies. Results HAART caused a significant decrease in body and testicular weight, testicular distortion and spermatogenic cell disorganization, altered semen quality and function, hormonal profiles, and oxidative stress markers (SOD, CAT, GSH) were significantly decreased with the concurrent increase in MDA level. However, treatment with MOE improved sperm parameters, testis morphology, antioxidants markers, and hormones assessments. Conclusions The exposure to HAART produced marked testicular toxicity, ameliorated using Moringa oleifera leaf extract, thereby preserving testicular physiological function and morphology.

show abstract

Antiretroviral Therapy and Alcohol Interactions: X-raying Testicular and Seminal Parameters Under the HAART Era

Ogedengbe

Naidu

Azu

2017

Eur J Drug Metab Pharmacokinet

View full text Add to dashboard Cite

The prevalence of alcohol use among HIV-infected patients undergoing antiretroviral (ARV) treatments has raised several concerns related to key therapeutic indices. These include drug interactions, compliance, efficacy and toxicity with the possibility of accelerated disease progression. Interaction of ARVs with alcohol can result in therapeutic failures or place patients at significant risk for toxicities. Research findings in this particular area are, however, limited and sometimes conflicting. This review focuses on alcohol and ARV interactions affecting testicular and spermatogenic indices. Antiretroviral drugs are known to negatively impact testicular functions via altered mitochondrial DNA and oxidative stress mechanisms. Interaction with alcohol can significantly affect seminal fluid concentration of ARVs. Habitual consumption of alcohol causes testicular hypofunction with potential for lowered fertility. Concomitant use of ARVs appears to act synergistically to exacerbate this toxicity. Alcohol also induces cytochrome P450 (CYPs) microsomal enzymes, which in turn affect ARVs metabolized by these enzymes. In the presence of ARVs with strong inhibitory activity, increased bioavailability with toxicities predominates. In addition, alcohol and ARVs have pronounced effects on membrane-associated drug transporters. Alcohol alters the properties of the lipid bilayer by changing membrane permeability and protein distribution. Since drug transporters critical to pharmacokinetics are integral membrane proteins, alcohol tends to diminish the activity of both the efflux and influx transporters. While excessive alcohol precipitates accelerated hypogonadism, future research needs to be directed to quantifying these effects of alcohol and ARVs in human testicular tissue.

show abstract

Histomorphological effect of zidovudine on the testes of adult male wistar rats (rattus novegicus)

Cited by 5 publications

References 30 publications

Effect of co-administration ofHypoxis hemerocallideaextract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats

Effect of co-administration ofHypoxis hemerocallideaextract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats

Moringa oleifera restored semen quality, hormonal profile, and testicular morphology against Highly Active Antiretroviral Therapy- induced toxicity in adult male Wistar rats

Antiretroviral Therapy and Alcohol Interactions: X-raying Testicular and Seminal Parameters Under the HAART Era

Contact Info

Product

Resources

About