2021
DOI: 10.14218/jcth.2020.00105
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Histone Deacetylase Inhibitors Romidepsin and Vorinostat Promote Hepatitis B Virus Replication by Inducing Cell Cycle Arrest

Abstract: Background and Aims: Chronic hepatitis B virus (HBV) infection is a global public health challenge. HBV reactivation usually occurs in cancer patients after receiving cytotoxic chemotherapy or immunosuppressive therapies. Romidepsin (FK228) and vorinostat (SAHA) are histone deacetylase inhibitors (HDACi) approved by the Food and Drug Administration as novel antitumor agents. The aim of this study was to explore the effects and mechanisms of HDACi treatment on HBV replication. Methods: To assess these effects, … Show more

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Cited by 3 publications
(2 citation statements)
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“…HepAD38 cells were cultured in a growth medium comprising Dulbecco’s modified Eagle’s medium (DMEM, HyClone, Logan, UT, USA) with the addition of 10% fetal bovine serum (FBS, Gibco, Rockville, MD, USA), 1 µg/mL tetracycline, 500 µg/mL G418, 100 units/mL penicillin (HyClone, Logan, UT, USA), and 100 µg/mL streptomycin (HyClone, Logan, UT, USA) as previously described. 12 To boost NTCP receptor expression in HepG2-NTCP, an additional 2 µg/mL of doxycycline was added to the growth medium. 13 …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…HepAD38 cells were cultured in a growth medium comprising Dulbecco’s modified Eagle’s medium (DMEM, HyClone, Logan, UT, USA) with the addition of 10% fetal bovine serum (FBS, Gibco, Rockville, MD, USA), 1 µg/mL tetracycline, 500 µg/mL G418, 100 units/mL penicillin (HyClone, Logan, UT, USA), and 100 µg/mL streptomycin (HyClone, Logan, UT, USA) as previously described. 12 To boost NTCP receptor expression in HepG2-NTCP, an additional 2 µg/mL of doxycycline was added to the growth medium. 13 …”
Section: Methodsmentioning
confidence: 99%
“…Animal administration used in this study has been described in the previous study. 12 The mice were administered intraperitoneal injections of phosphate-buffered saline (PBS, control) or PTX (10 mg/kg body weight) every other day for a total of seven injections. Half of the mice were sacrificed after the injection on the 14 th day, and the remaining mice were kept under observation until one week after drug withdrawal.…”
Section: Methodsmentioning
confidence: 99%