Histone H1 and Evolution of Sperm Nuclear Basic Proteins

Ausió, Juan

doi:10.1074/jbc.274.44.31115

Cited by 122 publications

(136 citation statements)

References 39 publications

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“…In addition to packing the DNA into the limited space of the nucleus, this chromatin remodeling brings about the almost complete shut off of gene expression, the erasing of the somatic histone epigenetic component (Ausió 1995), and probably provides some protection against external damaging agents during the journey of the sperm from the male gonad all the way to the egg (Caron et al 2005).…”

Section: Nuclear Reorganization During Spermatogenesismentioning

confidence: 99%

Paternal contribution to development: Sperm genetic damage and repair in fish

et al. 2017

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In this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization, showing the relationship between the integrity of the diverse elements and the development of a healthy offspring. The present knowledge about fish sperm chromatin organization, epigenetic modifications of DNA and histones and sperm-borne RNAs, essential in controlling embryo development, is summarized, pointing out the possibility of using specific genes or transcripts as biomarkers of sperm quality. Data about commercial species are reported when available and more detailed information about zebrafish sperm is presented.Considering the implications that the integrity of sperm genome and epigenome has on the preservation of a proper genotype and phenotype in the progeny, the methods applied for the study of chromatin damage and for the study of transcriptome are described. Moreover we discuss some injuring agents affecting paternal information, from the presence of contaminants in the aquatic environment, to the reproductive *Manuscript Click here to download Manuscript: Herrez et al revised aquaculture.docx Click here to view linked References practices applied in fish farming. The consequences of fertilizing with damaged spermatozoa, as well as the zygotic ability to repair damage are also reviewed.

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Section: Nuclear Reorganization During Spermatogenesismentioning

confidence: 99%

Paternal contribution to development: Sperm genetic damage and repair in fish

et al. 2017

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“…While the main driving forces for protamine-DNA binding are the ionic interactions, there is a distinct cooperativity that cannot be explained on the basis of electrostatic interactions alone [24]. Protamines perform functions similar to histones, but are generally smaller, with molecular weights between 4000 and 10,000 g/mol [25]. Non-covalent complexes between proteins and oligonucleotides have been studied in UV MALDI previously [26].…”

mentioning

confidence: 99%

Additives for the stabilization of double-stranded DNA in UV-MALDI MS

Distler

Allison

2002

J. Am. Soc. Mass Spectrom.

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“…There are five types of histone proteins: H1, H2A, H2B, H3 and H4 (4)(5)(6). Histone H1 is known as the linker histone, whereas the remaining four histone proteins are collectively known as the core histones.…”

Section: Introductionmentioning

confidence: 99%

Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line

2012

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Abstract. β-elemene is extracted from the Chinese medicinal herb Curcuma Wenyujin. It has a broad-spectrum antitumor effect on many types of cancer. However, the exact mechanism of action of β-elemene in hepatocellular carcinoma (HCC) remains unknown. Histone H1 is thought to act as a repressor of transcription by promoting the compaction of chromatin into higher order structures. We found that histone H1 plays an important role in the antitumor function of β-elemene. In this study, histone H1 expression in the H22 murine hepatocellular carcinoma cell line was confirmed, with P388D1 cells serving as a positive control. Furthermore, H22 cells were cultured with β-elemene for different time-points in vitro and treated with different dose-dependent β-elemene in an experimental H22 HCC xenograft transplantation model to confirm whether β-elemene inhibited the growth of H22 tumor cells. In addition, measurements of histone H1 expression both in vitro and in vivo enabled us to demonstrate that β-elemene affects the expression of histone H1 only at the protein level, but is not involved in regulation at the gene level. Our results clearly show that the effect of β-elemene on inhibiting the growth of H22 tumor cells is time-and dose-dependent. In conclusion, β-elemene inhibits the growth of H22 cells by enhancing the expression of histone H1 only at the protein level. This finding may provide insight into a new mechanism of the antitumor action of β-elemene.

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Histone H1 and Evolution of Sperm Nuclear Basic Proteins

Cited by 122 publications

References 39 publications

Paternal contribution to development: Sperm genetic damage and repair in fish

Paternal contribution to development: Sperm genetic damage and repair in fish

Additives for the stabilization of double-stranded DNA in UV-MALDI MS

Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line

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