Histopathologic Correlation of Residual Mammographic Microcalcifications After Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer

Adrada, Beatriz E.; Huo, Lei; Lane, Deanna L.; Arribas, Elsa; Resetkova, Erika; Yang, Wei Tse

doi:10.1245/s10434-014-4113-8

Cited by 58 publications

(42 citation statements)

References 20 publications

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“…Only mammography can enable an accurate assessment of the extent of microcalcifications, which is essential to determine the extent of excision. Several studies have reported that decreases in the size and density of the tumor mass on a mammogram were the most reliable indicators of treatment response [137]. By contrast, the appearance of and changes in microcalcifications associated with malignancy have been deemed inaccurate for evaluating tumor response [137].…”

Section: Discussionmentioning

confidence: 99%

“…These microcalcifications decreased in four patients, were stable in 21, were more conspicuous in 15, and were newly developed in four. Adrada et al [1] found that the extent of calcification after neoadjuvant chemotherapy had decreased in 35 of 106 patients with advanced breast cancer, but it had remained stable in 41 patients and had increased or was newly developed in 30 patients. They did not find any correlation between calcification changes and pathologic complete remission.…”

Section: Discussionmentioning

confidence: 99%

“…Adrada et al [1] showed that ER-positive cancers had a significantly higher proportion of residual malignant calcifications after neoadjuvant chemotherapy compared to ER-negative cancers. Therefore, they suggested that residual calcifications related to incomplete excision might be less of a concern in cases of ER-negative breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Neoadjuvant chemotherapy offers the advantage of reducing primary tumor size, thus allowing for the possibility of breast conservation surgery. Furthermore, evaluation of the tumor response to neoadjuvant chemotherapy also facilitates therapeutic regimen modification and the prediction of long-term outcomes [1]. …”

Section: Introductionmentioning

confidence: 99%

“…Residual microcalcifications after chemotherapy could be explained by the calcifications of necrotic residual tumor material, hematoma formation, or even fat necrosis [3]. To the best of our knowledge, only a few reports have described increased or newly developed malignant microcalcifications after neoadjuvant chemotherapy in patients with advanced breast cancer [1345]. …”

Section: Introductionmentioning

confidence: 99%

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Increased Malignant Microcalcifications after Neoadjuvant Chemotherapy in Advanced Breast Cancer

et al. 2016

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In patients with advanced breast cancer, most new calcifications detected on a mammogram after neoadjuvant chemotherapy are benign dystrophic calcifications, but this is not always observed. We present a patient with advanced breast cancer who had paradoxically increased malignant microcalcifications concomitant with primary tumor regression after undergoing neoadjuvant chemotherapy. After the neoadjuvant chemotherapy, the follow-up mammogram revealed that local, fine pleomorphic microcalcifications had markedly increased. Pathologically, these calcifications were ductal carcinoma in situ. We concluded that, in patients with breast cancer undergoing neoadjuvant chemotherapy, newly developed microcalcifications on follow-up mammograms should be carefully evaluated, and any suspicious malignant microcalcifications should be included in surgical excision planning.

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