Histopathologic Diagnosis of Pleural Metastasis of Renal Cell Carcinoma Using Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Kang, Yeh Rim; Jhun, Byung Woo; Jeon, Kyeongman; Koh, Won Jung; Suh, Gee Young; Chung, Man Pyo; Kim, Hojoong; Kwon, O Jung; Han, Joungho; Um, Sung Hee

doi:10.4046/trd.2011.71.5.355

Cited by 4 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our review of the literature revealed 13 case reports with malignant pleural effusion as the diagnostic presentation of RCC -to the best of our knowledge, making it an extremely rare phenomenon. The cases are listed in Table 1 [2,[6][7][8][9][10][11][12][13][14][15][16]. The primary presenting symptom was dyspnea.…”

Section: Discussionmentioning

confidence: 99%

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Wasifuddin¹,

Ilerhunmwuwa²,

Hakobyan³

et al. 2023

Cureus

View full text Add to dashboard Cite

Renal cell carcinoma is the most common renal neoplasm. Its presentation is often very occult, and it may be discovered incidentally. It may present with the classic symptoms of back pain, flank pain, hematuria, or hypertension. Renal cell carcinoma may also present with malignant pleural effusion at diagnosis; however, it is very rare. In this case report and literature review, we describe a 77-year-old male who was diagnosed with renal cell carcinoma after presenting with a malignant pleural effusion -an extremely rare phenomenon. An analysis of the literature yielded 13 case reports, including ours, where the diagnostic presentation of renal cell carcinoma was a malignant pleural effusion.Our patient presented with left-sided chest pain. Imaging was suggestive of pleural effusion. CT and MRI imaging demonstrated masses in the upper and lower poles of the right kidney suggestive of renal cell carcinoma. CT imaging also showed lung nodules that were suggestive of pulmonary metastases. Biopsy and immunostaining of pleural tissue were positive for clear cell renal cell carcinoma. Therapeutic thoracentesis was performed. Despite this, the patient developed recurrent large-volume pleural effusions requiring drainage and placement of a pleural catheter. Our patient's extremely rare presentation of malignant pleural effusion as the diagnostic presentation of renal cell carcinoma along with recurrent, large-volume effusions requiring drainage has only been reported in the form of case reports in the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Wasifuddin¹,

Ilerhunmwuwa²,

Hakobyan³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

Localized pleural metastasis without other organ metastases after nephrectomy for renal cell carcinoma

Saito¹,

Hata²,

Nishioka³

et al. 2021

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

We present a case of a 69-year-old man who had localized pleural metastasis without other organ metastases after nephrectomy for right renal cell carcinoma (RCC). He complained of respiratory symptoms for more than two years after the operation and was confirmed to have right pleural effusion and multiple pleural masses on computed tomography (CT). There were no abnormal findings in the other organs, but the pleural mass gradually increased in size on CT. We suspected malignant tumors such as malignant pleural mesothelioma and synovial sarcoma in addition to RCC metastasis. Finally, we performed surgical resection of the pleural mass under general anesthesia, and we diagnosed pathologically as metastasis from RCC. Distant metastases of RCC are common in the lungs, bones, brain, and liver. To our knowledge, localized pleural metastases from RCC is rare.

show abstract

Renal cell carcinoma with malignant pleural effusion: Case report and systematic review of literature

Goyal

Vias

Periasamy

et al. 2021

Journal of Onco-Nephrology

View full text Add to dashboard Cite

Introduction: Renal cell carcinoma metastasizes commonly to visceral organs such as adrenals, liver, lungs, or to bones. Metastases to body cavities such as pleura, pericardium and peritoneum are rare, and almost never in isolation. Case discussion: We discuss here a patient who was diagnosed with renal cell carcinoma following an episode of hematuria and underwent radical nephrectomy for the same. Within a month of surgery, he was evaluated for sudden onset breathlessness and detected to have massive left-sided pleural effusion, which returned malignant on pleural biopsy. The patient was treated with oral multikinase inhibitor following symptomatic therapy, with a favorable response. The imaging findings and relevant literature exploring the incidence of such presentations are discussed. Conclusion: Malignant effusions usually portend a poor prognosis but owing to the rarity of this condition and availability of newer therapies, long-term durable control may be expected.

show abstract

Histopathologic Diagnosis of Pleural Metastasis of Renal Cell Carcinoma Using Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Cited by 4 publications

References 10 publications

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Localized pleural metastasis without other organ metastases after nephrectomy for renal cell carcinoma

Renal cell carcinoma with malignant pleural effusion: Case report and systematic review of literature

Contact Info

Product

Resources

About