Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa

Sato, Kiminori; Umeno, Hirohito; Nakashima, Tadashi; Nonaka, Satoshi; Harabuchi, Yasuaki

doi:10.1016/j.jvoice.2010.10.006

Cited by 26 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our previous studies supported the hypothesis that the tensions caused by phonation after birth stimulate the VFSCs in the anterior and posterior maculae flavae to accelerate production of extracellular matrices and form the vocal ligament, Reinke's space, and the characteristic layered structure [8,10]. The vocal fold vibration (phonation) after birth is an important factor in the growth and development of the human vocal fold mucosa.…”

Section: Discussionsupporting

confidence: 82%

“…The most characteristic findings of the ultrastructural pathology of the interstitial cells in the unphonated vocal fold mucosa were morphological changes of the VFSCs in the maculae flavae [8,10]. On the other hand, the conventional fibroblasts in the lamina propria of the vocal fold mucosa were quiescent and did not have morphological changes.…”

Section: Discussionmentioning

confidence: 97%

“…Our previous studies revealed that the human child and adult vocal fold mucosae that had remained unphonated since birth were hypoplastic and rudimentary, and that the maculae flavae were atrophic and VFSCs had decreased their activity [8,10]. The most characteristic findings of the ultrastructural pathology of the interstitial cells in the unphonated vocal fold mucosa were morphological changes of the VFSCs in the maculae flavae [8,10].…”

Section: Discussionmentioning

confidence: 99%

“…Bilateral vocal folds were mobile and vocal fold paralysis was not detected in the patient. Normal younger adult larynges from autopsy cases that we previously reported on [5,7,[9][10][11] were used for comparison by light and electron microscopy.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Histopathologic study of human vocal fold mucosa unphonated over a decade

Sato

Umeno

Ono

et al. 2011

Acta Oto-Laryngologica

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Histopathologic study of human vocal fold mucosa unphonated over a decade

Sato

Umeno

Ono

et al. 2011

Acta Oto-Laryngologica

Self Cite

View full text Add to dashboard Cite

show abstract

“…The layered structure has been shown to lead to unique vibration characteristics such as mucosal wave propagation that are representative of voiced speech (Milutinović et al, 1998; Zhang et al, 2009; Sato et al, 2012). Two-layer physical and computational models have been used in the literature (Drechsel and Thomson, 2008; Riede et al, 2008; Mendelsohn and Zhang, 2011).…”

Section: Discussionmentioning

confidence: 99%

Validation of a flow–structure-interaction computation model of phonation

Bhattacharya

Siegmund

2014

Journal of Fluids and Structures

View full text Add to dashboard Cite

Computational models of vocal fold (VF) vibration are becoming increasingly sophisticated, their utility currently transiting from exploratory research to predictive research. However, validation of such models has remained largely qualitative, raising questions over their applicability to interpret clinical situations. In this paper, a computational model with a segregated implementation is detailed. The model is used to predict the fluid–structure interaction (FSI) observed in a physical replica of the VFs when it is excited by airflow. Detailed quantitative comparisons are provided between the computational model and the corresponding experiment. First, the flow model is separately validated in the absence of VF motion. Then, in the presence of flow-induced VF motion, comparisons are made of the flow pressure on the VF walls and of the resulting VF displacements. Self-similarity of spatial distributions of flow pressure and VF displacements is highlighted. The self-similarity leads to normalized pressure and displacement profiles. It is shown that by using linear superposition of average and fluctuation components of normalized computed displacements, it is possible to determine displacements in the physical VF replica over a range of VF vibration conditions. Mechanical stresses in the VF interior are related to the VF displacements, thereby the computational model can also determine VF stresses over a range of phonation conditions.

show abstract