Objective: Determine the epidemiological profile and histopathological aspects of testicular cancer in the two major cities of Cameroon, Yaoundé and Douala. Patients and methods: It was a retrospective cross-sectional descriptive study conducted in the reference structures approved for anatomopathological examination in Yaoundé and Douala. The study was conducted over a 17-year period (2001-2017). We included all cases of histologically confirmed testicular tumors. Variables included frequency, year of diagnosis, sociodemographic data, clinical aspects, types of sampling, gross macroscopy, and histological types. Results: We collected 81 cases of testicular tumors (49 benign tumors and 32 malignant tumors), with a mean age of diagnosis of 36.27 ± 18.9 years. For malignant tumors, the mean age was 40.25 ± 25.02 years, the predominant age group was 20-29 years (25%), the predominant type of specimen was the orchidectomy %, the predominant histological types were germ cell tumors with 30% seminomas. Concluson: Testicular tumoral pathology affects more young man and is dominated by seminoma-type germ tumors.