Histopathological and immunological study of rats liver hydatid cysts isolated from human, sheep, goat and cows

Alsaadawi, Mohenned A.; Al-Safar, Ali Husein Ali; Khudhur, Hasan Raheem; Mazeel, Saif; Hussein, Hussein muhhe; Allawi, Aqil Hussein; Ali, Mansour Jadaan

doi:10.1007/s12639-022-01512-3

Cited by 4 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tissues can be damaged during prolonged oxidative stress. These findings are consistent with [ 27 ], who discovered that AP increased the number of apoptotic cells. AP can accumulate in the liver and cause oxidative damage to hepatic cell membranes, causing transaminase to release into the bloodstream [ 28 ].…”

Section: Resultssupporting

confidence: 93%

Biochemical and histopathological changes in livers of rats poisoned with aluminum phosphide and treated with carrot extract

Al-Safar¹,

Jawad²,

Khayoon³

et al. 2023

Environ Anal Health Toxicol

View full text Add to dashboard Cite

The experimental studies of Aluminum Phosphide (AP) poisoning in rats revealed several clinical and pathological signs such as hemorrhage, sinusoidal dilatation, bile stasis, centrilobular necrosis, Kupffer cell hyperplasia, infiltration by mononuclear cells, and fatty infiltration in the liver tissues. This paper aimed to show the impact of carrots on the toxic effect of AP on the livers of adult rats (female). To investigate some biochemical and histopathological changes effects of AP in rats, sixty white female rats were equally divided into four groups, the first group (G1) was administered orally with 3mg/kg/ body weight of AP, the second group (G2) was orally treated with AP and 10% carrot extract at the same time. The third group (G3) administrated 10% carrot extract only. The fourth (G4) group was the negative control and was treated with distilled water only. The experiments continued for a month at the animal house of the Veterinary Medicine College of Baghdad University. The results revealed that high levels of liver enzymes and bilirubin were induced in G1 with decreasing total protein levels. The pathological examination revealed the presence of marked proliferation of Kupffer cells in G1 livers. However, the G2 group showed slight infiltration of lymphocytes in sinusoids. The pathological changes in the livers of G3 group showed slight cloudy swelling in hepatocytes compared with the normal texture of hepatocytes in G4. The data of this experiment showed that treatment with carrot extract significantly decreases the elevation in the level of liver function enzymes in animal poisoned with AP. In addition, treatment with carrot extract reduces the severe damage in the hepatic tissue that occurred in rats treated with AP only. In general, it could be concluded that treatment with carrot extract provides a remedial effect against the hepatotoxicity that is resulted from exposure to AP.

show abstract

Section: Resultssupporting

confidence: 93%

Biochemical and histopathological changes in livers of rats poisoned with aluminum phosphide and treated with carrot extract

Al-Safar¹,

Jawad²,

Khayoon³

et al. 2023

Environ Anal Health Toxicol

View full text Add to dashboard Cite

show abstract

“…The study revealed that (47%) were reported among (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) years old. This age group represents the working age group in society 37 ; therefore, it is normal to see the highest infection rate in this age group.…”

Section: Discussionmentioning

confidence: 98%

“…Symptoms were similar to the results of another study 17 . Another study in other countries reported fever, malaise, headache, abdominal pain, myalgia, nausea, vomiting, thrombocytopenia, and bleeding manifestations were the most common signs 15,21,34,39 . The clinical type of infection can be affected by factors such as host immune response, viral load, and lack of certain receptors 32 .…”

mentioning

confidence: 95%

“…The rapid increase in CCHF cases in 2010 has been noticed, therefore the Iraqi CDC initiated a number of awareness programs conducted by both the public and the medical community incorporating the Ministry of Agriculture (the responsible institution for animal welfare in Iraq) in order to control ticks by dipping and spraying animals 18 or inventing new therapeutic agents such as using herbal plants which can reduce the amount of environmental pollution 19 . In addition, there are an increased need to develop the knowledge about the role of immune system against this which needs to use ELISA or histopathology that should clear description for the pathogenic diseases [20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A retrospective study of Crimean-Congo hemorrhagic fever in Iraq

Adnan Shaker,

Tawfeeq Abd,

Jassim Alsalih

et al. 2024

Afr H. Sci.

View full text Add to dashboard Cite

Background: CCHF is transmitted via ticks biting and directly by contact with tissue or blood of infected patients or viremicanimals. This study intends to determine the occurrence of CCHF in Iraq between 2015 and 2019. Methods: This study was designed as a retrospective and descriptive cross-sectional study. It was approved the occurrence ofCCHF in Iraq with relation to some epidemiological and demographic data reported in the Iraqi Communicable Diseases ControlCenter (CDC)/zoonotic diseases section between 2015-2019. Results: Out of 206 suspected cases, only 17 were diagnosed as CCHF with a total fatality ratio of 52%, 25%, and 80% in 2015and 2018 respectively. However, no mortality was reported during 2016, 2017, and 2019. The mean age of the patients was 33years± 18 SD, in males mainly (76%). Moreover, the risk groups were 29 %, 23 %, 18 % 12 %, and 6 % for butchers, animaldealers, gainers, both housewives and students and children respectively. Conclusion: Strict precautions and precise surveillance should be implemented to control the disease and protect the communityby improving the diagnosis and treatment of CCHF. The authors recommend another future study to detect the genotypingand sequencing of CCHFV in Iraq. Keywords: Crimean–Congo hemorrhagic fever; Iraq; tick.

show abstract

“…CE in sheep is present in most pastoral and grazing areas of the world and is endemic in South America, Northern Africa, Siberia, Southern and Eastern Europe, Central Asia, and Western China [6]. The CE in sheep causes severe economic losses in livestock industry [7]. In addition, reduction of the infection of CE in sheep is beneficial for the prevention and control of CE by reducing the transmission risk of E. granulosus s.s [8,9].…”

Section: Introductionmentioning

confidence: 99%

Rapid and accurate screening of cystic echinococcosis in sheep based on serum Fourier‐transform infrared spectroscopy combined with machine learning algorithms

Dawuti

Dou

Zheng

et al. 2023

Journal of Biophotonics

View full text Add to dashboard Cite

Cystic echinococcosis (CE) in sheep is a serious zoonotic parasitic disease caused by Echinococcus granulosus sensu stricto (s.s.). Presently, the screening technology for CE in sheep is time-consuming and inaccurate, and novel screening technology is urgently needed. In this work, we combined machine-learning algorithms with Fourier transform infrared (FT-IR) spectroscopy of serum to establish a quick and accurate screening approach for CE in sheep. Serum samples from 77 E. granulosus s.s.-infected sheep to 121 healthy control sheep were measured by FT-IR spectrometer. To optimize the classification accuracy of the serum FI-TR method for the E. granulosus s.s.-infected sheep and healthy control sheep, principal component analysis (PCA), linear discriminant analysis, and support vector machine (SVM) algorithms were used to analyze the data.Among all the bands, 1500-1700 cm À1 band has the best classification effect; its diagnostic sensitivity, specificity, and accuracy of PCA-SVM were 100%, 95.74%, and 96.66%, respectively. The study showed that serum FT-IR spectroscopy combined with machine learning algorithms has great potential for rapid and accurate screening methods for the CE in sheep.

show abstract

Histopathological and immunological study of rats liver hydatid cysts isolated from human, sheep, goat and cows

Cited by 4 publications

References 32 publications

Biochemical and histopathological changes in livers of rats poisoned with aluminum phosphide and treated with carrot extract

Biochemical and histopathological changes in livers of rats poisoned with aluminum phosphide and treated with carrot extract

A retrospective study of Crimean-Congo hemorrhagic fever in Iraq

Rapid and accurate screening of cystic echinococcosis in sheep based on serum Fourier‐transform infrared spectroscopy combined with machine learning algorithms

Contact Info

Product

Resources

About