Histopathological changes in gill, liver and kidney of neotropical fish Colossoma macropomum exposed to paraquat at different temperatures

Salazar-Lugo, Raquel; Mata, Claunis; Oliveros, Aridays; Rojas, Luz Marina; Lemus, Mairín; Rojas-Villarroel, Evelin

doi:10.1016/j.etap.2011.02.002

Cited by 36 publications

(13 citation statements)

References 11 publications

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“…The hepatic structure of the unexposed female P. reticulata was similar to that of other fish species, such as Colossoma macropomum (Salazar-Lugo et al, 2011) and Solea senegalensis (Costa et al, 2011). However, the short-term exposure to GBH (24 h) at an environmentally realistic GLY concentration (1.8 mg GLY L À1 ) (USEPA, 1993) changed the hepatic morphology and induced different hepatotoxic effects in female P. reticulata.…”

Section: Discussionmentioning

confidence: 70%

A glyphosate-based herbicide induces histomorphological and protein expression changes in the liver of the female guppy Poecilia reticulata

et al. 2017

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Section: Discussionmentioning

confidence: 70%

A glyphosate-based herbicide induces histomorphological and protein expression changes in the liver of the female guppy Poecilia reticulata

et al. 2017

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“…In the Amazon basin, tambaqui is one of the most important commercial fish ( Val and Honczaryk, 1995 ). It also presents many characteristics of an appropriate bioindicator species for biomonitoring programs ( Salazar-Lugo et al , 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Ras oncogene and Hypoxia-inducible factor-1 alpha (hif-1α) expression in the Amazon fish Colossoma macropomum (Cuvier, 1818) exposed to benzo[a]pyrene.

et al. 2017

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Benzo[a]pyrene (B[a]P) is a petroleum derivative capable of inducing cancer in human and animals. In this work, under laboratory conditions, we analyzed the responses of Colossoma macropomum to B[a]P acute exposure through intraperitoneal injection of four different B[a]P concentrations (4, 8, 16 and 32 μmol/kg) or corn oil (control group). We analyzed expression of the ras oncogene and the Hypoxia-inducible factor-1 alpha (hif-1α) gene using quantitative real-time PCR. Additionally, liver histopathological changes and genotoxic effects were evaluated through the comet assay. Ras oncogene was overexpressed in fish exposed to 4, 8 of 16 μmol/kg B[a]P, showing 4.96, 7.10 and 6.78-fold increases, respectively. Overexpression also occurred in hif-1α in fish injected with 4 and 8 μmol/kg B[a]P, showing 8.82 and 4.64-fold increases, respectively. Histopathological damage in fish liver was classified as irreparable in fish exposed to 8, 16 and 32 μmol/kg μM B[a]P. The genotoxic damage increased in fish injected with 8 and 16 μmol/kg in comparison with the control group. Acute exposure of B[a]P was capable to interrupt the expression of ras oncogene and hif-1α, and increase DNA breaks due to tissue damage.

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“…Many water sources have already been polluted by PCBs at different levels 11 12 . Fish are a powerful vertebrate model system for assessing the health of aquatic environments; physiological changes in fish can serve as biomarkers of environmental pollution 14 . Although the transformation of PCB isomers is limited in fish, non-racemic PCBs have been observed in fish exposed to PCBs via water and diet 15 .…”

mentioning

confidence: 99%

Enantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149

Chai

Cui

et al. 2016

Sci Rep

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Enantioselective enrichment of chiral PCB149 (2,2’,3,4’,5’,6-hexachlorobiphenyl) was analysed in adult zebrafish (Danio rerio) exposed to the racemate, (−)-PCB149, and (+)-PCB149. Greater enrichment of (−)-PCB149 compared to (+) PCB149 was observed following 0.5 ng/L exposure; however, as the exposure time and concentration increased, racemic enrichment was observed in adult fish exposed to the racemate. No biotransformation between the two isomers was observed in fish exposed to single enantiomers. When zebrafish were exposed to different forms of chiral PCB149, enantioselective expression of genes associated with polychlorinated biphenyls (PCBs) was observed in brain and liver tissues and enantioselective correlations between bioconcentration and target gene expression levels were observed in brain and liver tissues. The strong positive correlations between expression levels of target genes (alox5a and alox12) and PCB149 bioconcentration suggest that prolonged exposure to the racemate of chiral PCB149 may result in inflammation-associated diseases. Prolonged exposure to (−)-PCB149 may also affect metabolic pathways such as dehydrogenation and methylation in the brain tissues of adult zebrafish. Hepatic expression levels of genes related to the antioxidant system were significantly negatively correlated with bioconcentration following exposure to (+)-PCB149.

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Histopathological changes in gill, liver and kidney of neotropical fish Colossoma macropomum exposed to paraquat at different temperatures

Cited by 36 publications

References 11 publications

A glyphosate-based herbicide induces histomorphological and protein expression changes in the liver of the female guppy Poecilia reticulata

A glyphosate-based herbicide induces histomorphological and protein expression changes in the liver of the female guppy Poecilia reticulata

Ras oncogene and Hypoxia-inducible factor-1 alpha (hif-1α) expression in the Amazon fish Colossoma macropomum (Cuvier, 1818) exposed to benzo[a]pyrene.

Enantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149

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