Histopathological changes in the pancreas of cattle with abdominal fat necrosis

Abstract

The association between pancreatic disorder and abdominal fat necrosis in cattle remains unclear. The pancreases of 29 slaughtered cattle with or without fat necrosis were collected to investigate pathological changes. Japanese Black (JB) cattle were classified into the FN group (with abdominal fat necrosis; n=9) and N group (without fat necrosis; n=5). The pancreases were also collected from 15 Holstein Friesian (HF) cows. All JB cattle showed high body condition scores. Regarding the pathological findings, fatty pancreas which involves adipocyte infiltration into the pancreas and fat necrosis (saponification) were observed in 25 and 27 cases, respectively. Immunohistochemical staining with anti-Iba-1 antibody showed large numbers of macrophages surrounding the saponified fat in the pancreas. CD3-positive T cells were significantly more common in the pancreas of both the FN and N groups compared with the HF group (P<0.05). Furthermore, fibrosis in the pancreas exhibited a correlative tendency with the formation of necrotic fat mass in the peritoneal cavity (P<0.1). These results indicate that obesity leads to increased severity of pancreatic disorder, including fatty pancreas and pancreatitis. The pathological lesions in the pancreas may play a key role in abdominal fat necrosis through the inflammatory process.

Eurytrema coelomaticum natural infection in small ruminants: a neglected condition

“…AFN has not been reported in small ruminants and cattle with PE and is rarely reported in domestic ruminants with other conditions (Smith et al ., 2004; Santos et al ., 2008; Tharwat and Buczinski, 2012; Tani et al ., 2017). The aetiology of AFN is complex and not well established (Smith et al ., 2004; Tani et al ., 2017) and is possibly associated with the leakage of pancreatic enzymes in PE cases. The inspection of the paddocks of the flocks in this study did not identify fescue grass, abdominal trauma was not recorded in goats with AFN and any genetic predisposition of goats or sheep to AFN remains unrecognized.…”

“…Histological findings of AFN detected in the three goats with PE were similar to steatonecrosis everywhere (Smith et al ., 2004; Santos et al ., 2008; Tharwat and Buczinski, 2012; Tani et al ., 2017). The seriousness of the parasitic pancreatic damage in the goats presumably resulted in severe abdominal fat tissue necrosis.…”

Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

“…As expected, results showed a significant elevation in serum activities of pancreatic lipase, trypsinogen 1 and trypsinogen 2. Although there is paucity of data in the recent literature that indicate pancreatic damage associated with LDA in cows, severe histopathological pancreatic lesions including fatty pancreas and pancreatitis were found in dairy cows with abdominal fat necrosis and obesity (Tani et al 2017). Only serum amylase has previously been studied in cows affected with LDA (Aly et al 2016).…”

A Postmortem Case Study—An Analysis of microRNA Patterns in a Korean Native Male Calf (Bos taurus coreanae) That Died of Fat Necrosis

“…These necrotic fat masses are multifocally found in various sites, including intestines, mesentery of the spiral colon, mesorectum and the retroperitoneal area. This disease is very complex and causes intestinal obstruction and some clinical symptoms, such as sclerous feces, constipation and chronic anorexia [ 7 ]. Cattle afflicted with fat necrosis exhibit digestive disruptions caused by physical constriction or obstruction from the fat masses.…”

“…Symptoms include reduced fecal output, bloating and, in some cases, mortality [ 6 ]. The incidence of fat necrosis has been reported in the cattle industry since the 1960s, especially in Japan [ 7 ] and Korea [ 4 ]. Obesity, heredity, lack of exercise and intake of a high-energy diet have all been associated with the occurrence of fat necrosis [ 7 ].…”