Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals

Zissu, D.

doi:10.1002/jat.2550150311

Cited by 38 publications

(13 citation statements)

References 13 publications

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“…1 The Expert Panel reviewed newly available studies since that assessment along with updated frequency and concentration of use information. 2–12 The Expert Panel determined to not reopen this safety assessment and confirmed that diisopropylamine is safe as a cosmetic ingredient when used in products that do not contain N -nitrosating agents.…”

Section: Resultsmentioning

confidence: 99%

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Andersen¹

2011

Int J Toxicol

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This Annual Review of Cosmetic Ingredient Safety Assessments updates and affirms the findings of the Cosmetic Ingredient Review (CIR) Expert Panel's assessment of almost 30 compounds used in cosmetic ingredients. The review also summarizes new findings from epidemiology studies of hair dyes. The CIR Expert Panel's re-review process is intended to uncover any new data since the last safety assessment. In some cases, newly available data are largely redundant compared with the data available in the original safety assessment. In other cases, new data present new safety issues. If after considering the newly available information, the CIR Expert Panel decides to not reopen a safety assessment, this finding, along with any background material, is summarized and announced publicly. To assure that the scientific community is aware of any new information and the decision not to reopen, this Annual Review of Cosmetic Ingredient Safety Assessments is prepared. A list of reference sources is provided after each ingredient re-review summary that updates the available published literature and includes any unpublished data made available since the original safety assessment. The re-review also captures information on the industry's current practices of ingredient use, updating the data available in the earlier report. Although this material provides the opinion of the CIR Expert Panel regarding the new data described, it does not constitute a full safety review. The CIR Expert Panel has assessed the safety of over 2100 cosmetic ingredients since its inception in 1976. These safety assessments were published in the

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Section: Resultsmentioning

confidence: 99%

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Andersen¹

2011

Int J Toxicol

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“…We found that absorption of inhaled PAL (% absorbed) by both rat and mouse decreased at the 100-ppm exposure concentration relative to the 1-and 10-ppm exposures. Zissu (1995) reported the observation that inhalation exposure to PAL ( ¹ 25 and 88 ppm) results in a decrease in respiratory rate in the Swiss mouse. Respiratory rate was not measured in the current studies, and the amount of PAL inhaled was assumed to be the theoretical amount inhaled during the 6-h exposure based on a normal respiratory rate.…”

Section: Discussionmentioning

confidence: 97%

Disposition of propargyl alcohol in rat and mouse after intravenous, oral, dermal and inhalation exposure

et al. 2001

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1. The disposition of propargyl alcohol (PAL) radiolabelled with carbon-14 ([2,3-14C]PAL) was determined in the F344 rat and B6C3F1 mouse following intravenous (i.v.), oral, inhalation and dermal exposure. 2. By 72h following an i.v. (1 mg kg(-1) or oral (50 mg kg(-1) dose, 76-90% of the dose was excreted. Major routes of excretion by rat were urine (50-62%), CO2 (19-26%) and faeces (6-14%). Major routes of exerection by mouse were urine (30-40%), CO2 (22-26%) and faeces (10-20%). Less than 6% of the dose remained in tissues at 72 h. Biliary exeretion of radioactity by rat (62% in 4 h) was much greater than elimination in faeces (6% in 72 h), indicating that PAL metabolites underwent extensive enterohepatic recycling. 3. Dermal exposure studies demonstrated that dermal absorption of PAL was minimal due to its inherent volatility. 4. In the inhalation studies (1, 10 or 100 ppm for 6 h), 23-68% of the radioactivity to which animals were exposed was absorbed. The primary route of excretion was urine (23-53%), and significant portion was exhaled as volatile organics (15-30%). 5. PAL was extensively metabolized by both species. One metabolite was identified as 3,3-bis[(2-(acetylamino)-2-carboxyethyl)thio]-1-propanol, which is consistent with Banijamali et al. (1999).

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“…2 Zissu (1995) 2 Study well documented, meets generally accepted scientific principles, acceptable for assessment…”

Section: Registrants' Reliability Evaluationsmentioning

confidence: 99%

Improving structure and transparency in reliability evaluations of data under REACH: suggestions for a systematic method

Ingre-Khans

Ågerstrand

Rudén

et al. 2019

Human and Ecological Risk Assessment: An International Journal

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The goal of identifying hazardous chemicals registered under the Registration, Evaluation, Authorization and restriction of CHemicals (REACH) Regulation and taking appropriate risk management measures relies on robust data registrations. However, the current procedures for European chemical manufacturers and importers to evaluate data under REACH neither support systematic evaluations of data nor transparently communicate these assessments. The aim of this study was to explore how using a data evaluation method with predefined criteria for reliability and establishing principles for assigning reliability categories could contribute to more structured and transparent evaluations under REACH. In total, 20 peer-reviewed studies for 15 substances registered under REACH were selected for an in-depth evaluation of reliability with the SciRAP tool. The results show that using a method for study evaluation, with clear criteria for assessing reliability and assigning studies to reliability categories, contributes to more structured and transparent reliability evaluations. Consequently, it is recommended to implement a method for evaluating data under REACH with predefined criteria and fields for documenting and justifying the assessments to increase consistency of data evaluations and transparency.

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Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals

Cited by 38 publications

References 13 publications

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Disposition of propargyl alcohol in rat and mouse after intravenous, oral, dermal and inhalation exposure

Improving structure and transparency in reliability evaluations of data under REACH: suggestions for a systematic method

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