HISTOPATHOLOGICAL CHANGES INDUCED IN THE NORMAL THYROID AND OTHER TISSUES OF THE RAT BY INTERNAL RADIATION WITH VARIOUS DOSES OF RADIOACTIVE IODINE<sup>1</sup>

Goldberg, R. C.; Chaikoff, I.L.; Lindsay, Stuart; Feller, David

doi:10.1210/endo-46-1-72

Cited by 69 publications

(25 citation statements)

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“…The results of clearance studies in a second group of hypothyroid rats, who did not have blood drawn for Ts uptake determinations, were indistinguishable from the results obtained in the first group with these determinations. Radio iodide used in this manner has been shown to produce the same renal ultrastructural changes as seen in hypothyroidism induced with propylthiouracil (9), and does not permanently alter parathyroid structure (10). Neither hypothyroidism nor radio iodide altered plasma urea (Table III).…”

Section: Methodsmentioning

confidence: 87%

Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat

Holmes¹,

Discala²

1970

J. Clin. Invest.

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A B S T R A C T The exaggerated natriuresis of hypothyroid rats receiving a 5% saline infusion was studied to determine the mechanism and the site within the nephron responsible for this increase in sodium excretion. Sodium clearance (CNa) and fractional sodium excretion were both demonstrated to be greater in hypothyroid rats for any amount of sodium infused. The rate of increase in fractional sodium excretion in response to saline loading was 3.4 times greater in hypothyroid animals. At the conclusion of the diuresis some of the hypothyroid animals excreted greater than 45% of the filtered sodium load, while no control animal excreted more than 12% of the filtered sodium load.The mean clearance of insulin during the saline diuresis was 36.6% lower (P < 0.001) in the hypothyroid rats. D-Aldosterone given to hypothyroid animals 3 hr before the experiment did not alter the magnitude or rate of increase in fractional sodium excretion. Inulin space determinations in nephrectomized rats revealed that extracellular fluid volume was contracted by 17.1% in the hypothyroid rats (P < 0.01). Plasma sodium was not significantly different in hypothyroid and control animals.A limit on solute free water reabsorption (T'Huo) per osmolar clearance (Co..) was demonstrated in the hypothyroid rats when these animals excreted greater than 12% of the filtered osmotic load. The limit on TCH20 formation was associated with an acceleration in the rate of sodium excretion and a decline in the rate of potassium excretion. Early in the diuresis when Co.., CNa, and TCH20 were comparable in hypothyroid and control Received for publication 5 January 1970.rats, the filtered sodium load was 31% lower (P < 0.01) in the hypothyroid animals. These findings indicate that diminished thyroid hormone activity decreases renal sodium reabsorptive capacity. Indirect evidence suggests that the distal and possibly the proximal tubules are the sites of this diminished sodium reabsorption in hypothyroid animals. INTRODUCTIONHypothyroidism has profound effects on salt and water metabolism in the rat. These are manifested by an increase in water consumption and excretion (1), inability to elaborate a maximally concentrated urine (2), exaggerated natriuresis during a water or saline diuresis (3,4), and impaired ability to conserve sodium, resulting in a negative sodium balance and death when sodium intake is restricted (5). Fregly, Cade, Waters, Straw, and Taylor (4,6) have demonstrated a decreased secretory rate and tubular response to aldosterone in hypothyroid rats, and they have proposed that thyroid insufficiency influences sodium reabsorption through this indirect mechanism. Reville and Stephan (7), however, have recently presented evidence in adrenalectomized hypothyroid rats which suggested that the alteration of sodium metabolism observed in hypothyroid animals was independent of adrenal function. In the present study several of the factors which regulate sodium reabsorption were evaluated with the hope of determining what mechanism might be responsi...

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Section: Methodsmentioning

confidence: 87%

Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat

Holmes¹,

Discala²

1970

J. Clin. Invest.

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“…Intraperitoneal administration of 131 I in solution results in transient or permanent hypothyroidism in adult rats (250 g BW) depending on the dose used (213). A progressive thyroidal degenerative process is observed after administration of 300 or 525 lCi 131 I but regeneration occurs after several months; regeneration is not seen when 875 lCi is used (213). Other tissues may be damaged by the radiation: fibrosis of the parathyroid glands has been observed when 525 or 875 lCi of 131 I is used.…”

Section: And Recommendation 20amentioning

confidence: 99%

“…Other tissues may be damaged by the radiation: fibrosis of the parathyroid glands has been observed when 525 or 875 lCi of 131 I is used. There can be tracheal damage and transient renal effects (213). No damage to the liver has been observed (213 Commentary.…”

Section: And Recommendation 20amentioning

confidence: 99%

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American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

Bianco

Anderson

Forrest

et al. 2014

Thyroid

174

106

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“…Following ~'le "discovery" of very low aerrm oal.cium levels (less than 6 ~), ·th(t parathyroid glB.nds were specifically nought at necropsy, e.nd histological preparations wre made of peri tracheal tissue. (43,45,116 …”

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confidence: 99%

THE EFFECTS OF THYROID AND PARATHYROID DEFICIENCY ON REPRODUCTION IN THE RAT¹

1960

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HISTOPATHOLOGICAL CHANGES INDUCED IN THE NORMAL THYROID AND OTHER TISSUES OF THE RAT BY INTERNAL RADIATION WITH VARIOUS DOSES OF RADIOACTIVE IODINE¹

Cited by 69 publications

References 0 publications

Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat

Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

THE EFFECTS OF THYROID AND PARATHYROID DEFICIENCY ON REPRODUCTION IN THE RAT¹

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HISTOPATHOLOGICAL CHANGES INDUCED IN THE NORMAL THYROID AND OTHER TISSUES OF THE RAT BY INTERNAL RADIATION WITH VARIOUS DOSES OF RADIOACTIVE IODINE1

Cited by 69 publications

References 0 publications

Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat

Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

THE EFFECTS OF THYROID AND PARATHYROID DEFICIENCY ON REPRODUCTION IN THE RAT1

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HISTOPATHOLOGICAL CHANGES INDUCED IN THE NORMAL THYROID AND OTHER TISSUES OF THE RAT BY INTERNAL RADIATION WITH VARIOUS DOSES OF RADIOACTIVE IODINE¹

THE EFFECTS OF THYROID AND PARATHYROID DEFICIENCY ON REPRODUCTION IN THE RAT¹