Histopathological changes of brucellosis in experimentally infected guinea pig

Karim, M. F.; Maruf, A. A.; Yeasmin, Farzana; Shafy, N. M.; Khan, A. H. N. A.; Rahman, Abdur; Bhuiyan, M. J. S.; Hasan, M. M.; Karim, Mohammad Rabiul; Hasan, Muhtar; Rahman, Mohammad Saidur

doi:10.33109/bjvmjj19lam4

Cited by 1 publication

(1 citation statement)

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“…In tissues, the typical histopathological response to Brucella infection is a granulomatous inflammation, which contains representative members of the MPS, including macrophages with an epithelioid shape, i.e., with an increased amount of cytoplasm. Examination of biopsies from humans and livestock animals reveals granulomas in the liver, spleen, bone marrow, and other tissues [ 79 , 80 , 81 , 82 ]. As such, the initial replication niche of Brucella serves as a platform to establish a chronic infection.…”

Section: Gold Organs In Brucellosismentioning

confidence: 99%

Brucella: Reservoirs and Niches in Animals and Humans

et al. 2021

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Brucella is an intracellular bacterium that causes abortion, reproduction failure in livestock and leads to a debilitating flu-like illness with serious chronic complications if untreated in humans. As a successful intracellular pathogen, Brucella has developed strategies to avoid recognition by the immune system of the host and promote its survival and replication. In vivo, Brucellae reside mostly within phagocytes and other cells including trophoblasts, where they establish a preferred replicative niche inside the endoplasmic reticulum. This process is central as it gives Brucella the ability to maintain replicating-surviving cycles for long periods of time, even at low bacterial numbers, in its cellular niches. In this review, we propose that Brucella takes advantage of the environment provided by the cellular niches in which it resides to generate reservoirs and disseminate to other organs. We will discuss how the favored cellular niches for Brucella infection in the host give rise to anatomical reservoirs that may lead to chronic infections or persistence in asymptomatic subjects, and which may be considered as a threat for further contamination. A special emphasis will be put on bone marrow, lymph nodes, reproductive and for the first time adipose tissues, as well as wildlife reservoirs.

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