Histopathological effects of chronic exposure to lead on kidneys of brown trout (Salmo trutta m. Fario)

Abstract

The aim of the present study was to investigate the histopathological changes on the kidneys of the brown trout (Salmo trutta m. Fario) inflicted by per os lead poisoning in the 46-week experimental period. The fish were kept in well-oxygenated freshwater basins. Approximately calculated toxic doses of lead-acetate for fish were 550 mg/kg. Following the experimental period, fish organs, in particular kidneys, were examined by light microscopy. Only fish with lesions observed in kidneys were further examined by electron microscopy. An accumulation of proteinaceous material in the glomeruli of the kidneys, and thickening of the basal membrane were observed histopathologically. This proteinaceous material was also observed in the lumina of the kidney tubules. Electron microscopic examination completely supported this finding. Furthermore, to the authors' previous knowledge, undocumented damage of the brush borders of the proximal kidney tubules was also observed

Inhibition of cadmium- induced genotoxicity and histopathological changes in Nile tilapia fish by Egyptian and Tunisian montmorillonite clay

“…The changes in the gills in our study were clear in case of fish group exposed to cadmium and were characterized by hyperplasia of gill filaments, congestion and eosinophilic granular cells infiltration; the results were go parallel with the findings of Besirovic et al (2010). The changes in the gills were also noticed in the treated group; however it is not indicative to inefficiency of the clays to inhibit the toxicity but it may attributed to failure of the tissue to regenerate the chronic changes that noticed in branchial tissue.…”

“…Heavy metals can affect aquatic organisms through water, sediment or food chain (Zyadah, 1995). Cadmium (Cd) is an important inorganic toxicant widely distributed in the environment because of its various industrial uses and it is a nonessential element to all living organisms (Randi et al, 1996;Besirovic et al, 2010). Also contamination of groundwater from smelting and industrial uses as well as the use of sewage sludge as a food-crop fertilizer.…”

Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania

“…The higher bioaccumulation of Zn in kidney contributes substantially to injury, probably due to distal tubules deposition (Woodling et al 2001). The increase of zinc resorption in tubules can cause changes related to osmotic nephrosis and convoluted proximal tubules become hypertrophic and hyperplastic (Besirovic et al, 2010). The dose sufficient to cause osmotic-type nephroses also increases frequency and a degree of lesions related to chronic progressive nephropathies (Haschek et al, 2002).…”

Metal pollution assessment in a Brazilian hydroelectric reservoir: Geophagus brasiliensis as a suitable bioindicator organism

“…It is known that not all metals taken up by organisms are bioaccumulated; fish can, to a certain degree, regulate metal concentration in tissues (Maceda-Veiga et al, 2012;Pourang et al, 2005), but Cd is one of the most toxic metals, as it is nonessential, and can quickly bioaccumulate in fish (Liu et al, 2011). Even though metallothioneins tend to detoxify nonessential elements (Hansen et al, 2007), their excretion is a slow process (Besirovic et al, 2010). Accordingly, a previous study by Calza et al (2004) also demonstrated the absence of Cd accumulation in G. brasiliensis tissues.…”