Histopathological effects of fibrin glue on penile fracture in a rat model

Taşdemir, Cemal; Şamdancı, Emine; Turtay, Muhammet Gökhan; Fırat, Cemal; Oğuztürk, Hakan; Özdemir, Hülya

doi:10.25011/cim.v34i6.15893

Cited by 4 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 23 ] However, in other studies by Akgül et al and Taşdemir et al, it was observed that fibrosis decreased in the tissues of rats that underwent primary repair after PF. [ 6 , 7 ] Similarly, in our study, it was observed that fibrosis did not increase in rats that underwent primary repair. Intense fibrosis was observed in the PA and PRA groups at the end of the study, although this was not statistically significant between the two groups (p=0.077).…”

Section: Discussionsupporting

confidence: 78%

“…In our study, hyperemia and bleeding were observed in all groups, similar to the study by Akgül et al[ 23 ] In another study conducted by Akgül et al, when cyanoacrylic glue (CG) was applied to PF animals, a decrease in hyperemia was observed, attributed to the hemostatic property of CG. [ 6 ] Therefore, we observed hyperemia and bleeding in all rat tissues. However, in our study, hyperemia was significantly less common in the PRA group.…”

Section: Discussionmentioning

confidence: 85%

“…[3][4][5] Increased inflammation has been reported in PF in rats. [6,7] The inflammatory response involves perivascular infiltration of lymphocytes, monocytes, and neutrophils at the site of injury. [8] This is followed by the excessive generation of free radicals known as reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Girgin

2024

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

BACKGROUND: This study assessed the histopathological and oxidative effects of topical Aloe Vera (AV) on penile fractures (PF) formed experimentally in a rat model. METHODS: Forty Wistar albino rats (220-250 g) were used. The PF model was created experimentally with a number 15 lancet. Then, the rats were randomly and equally divided into five groups. In the first group (C), no incision was formed. In the second group (P), an incision was formed. In the third group (PR), the incision line was closed primarily. In the fourth group (PA), AV was locally applied onto the incision without suturing for three days. In the last group (PRA), AV was applied to the primary repair region for three days. All groups were compared to each other according to histopathological and biochemical data. RESULTS: Hyperemia-bleeding was observed to be suppressed in the PRA group compared to the other groups (p<0.001). Inflammation was observed only in Groups PR and PRA (p<0.001). Significant fibrosis was observed in the PA and PRA groups compared to the other groups (p<0.001). Superoxide Dismutase (SOD) and Glutathione (GSH) values increased in favor of Group PRA (p=0.009 and p=0.035, respectively). Total Oxidative Status (TOS) and Malondialdehyde (MDA) values decreased in favor of Group PA (p=0.036 and p=0.026, respectively). Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-1 beta (IL-1ß) levels decreased mostly in the PRA group, but these changes did not reach statistical significance (p>0.05). CONCLUSION: Topical AV application reduces tissue inflammation and oxidative stress but appears to increase the development of fibrosis after PF.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Girgin

2024

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…Increased inflammation was reported in PF of rats (Akgul et al, 2008;Tasdemir et al, 2011). The inflammatory response involves perivascular infiltration of lymphocytes, monocytes, and neutrophils at the site of injury (Somers et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Beneficial influence of topical extra virgin olive oil application on an experimental model of penile fracture in rats

et al. 2013

View full text Add to dashboard Cite

Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation was also realized. A total of 18 male Sprague-Dawley albino rats were divided into three groups of six rats each as control group, in PF (alone) group, and PF + EVOO group. Experimental PF was formed via incising from the proximal dorsal side of the penis in the rats of all groups except control. While in PF (alone) group, fracture was formed and the incision was primarily closed, in PF + EVOO group in addition to foregoing processes, EVOO was also administrated topically twice a day for 3 weeks. At the end of the experiment, all rats were killed and penectomy was carried out. While malondialdehyde, myeloperoxidase, lipid hyroperoxide, and total oxidant status significantly (p < 0.05) increased, reduced glutathione and total free sulfhydryl groups markedly (p < 0.05) decreased in PF (alone) group when compared with PF + EVOO group. Levels of these parameters were reversed to nearly normal values by topical EVOO application. Protection by EVOO is further substantiated via the improved histological findings in PF + EVOO group as against degenerative changes in the rats of PF (alone) group. Our data revealed that EVOO has protective effect in penile cavernosal tissue through probably its antioxidant, free radical defusing, anti-inflammatory, and antimicrobial effects.

show abstract

“…Sections were scored in accordance with the modified method of Tasdemir et al (2011) based on histopathological findings as: absent (-), slight (+), moderate (++) and extensive (+++).…”

Section: Histopathological Analysismentioning

confidence: 99%

The Effect of Platelet Rich Plasma on Wound Healing in the Repair of Experimental Penile Fractures

Beğer

Sağlam

Düz

et al. 2021

IJAR

View full text Add to dashboard Cite

Background: Penile fractures are caused by the rupture of the tunica albuginea and the underlying layers of corpus cavernosum as a result of the exposure of the erect penis to blunt trauma. Although conservative treatment methods have been recommended in former studies, recent studies favor early surgical options. Platelet-rich plasma (PRP) is a blood product rich in cytokines and several growth factors, obtained from the patient’s own blood commonly used to stimulate healing in acute and chronic wound treatments. The efficiency of homologous PRP treatment in rats with penile fractures have been assessed in terms of clinical manifestation and histopathological findings in the present study. Methods: Thirty-five rats were randomly divided into five groups, each containing seven rats as follows: 1. Conservative group: Following the formation of penile fracture, medical interventions were not initiated on fracture area and the wound was left for secondary healing. 2. Bandage group: Following the formation of penile fracture, self-adherent elastic bandage (3M Coban) was applied to the fracture area for three days. 3. Primary repair group: Following the formation of a penile fracture, the lacerated area was repaired with 7/0 vicryl primary sutures. 4. Primary repair + Homologous Platelet Rich Plasma group: Before the operation, 10 cc of blood was taken from one rat under general anesthesia by intracardiac puncture and PRP material was prepared from this blood. Homologous PRP was topically administered on the wound in the fracture area and then the penile fracture was repaired with 7/0 vicryl as simple separate stitches. 5. Non-operative control group: Surgical procedures were not applied to this group; it was used as the control group. Result: The effect of the PRP treatments on the surgical repair options in the rats with penile fractures was investigated. The present findings revealed that following the repair with conservative treatments, the fracture format persisted and various complications like infection, oedema, excessive fibrosis and hyperemia were encountered. On the other hand, the best healing was achieved in primary repair + PRP group in terms of clinical manifestation and histopathological findings.

show abstract

Histopathological effects of fibrin glue on penile fracture in a rat model

Abstract: Purpose: To evaluate both histopathological e ects and potential clinical application of brin glue on the penile cavernosal tissue.

Cited by 4 publications

References 25 publications

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Beneficial influence of topical extra virgin olive oil application on an experimental model of penile fracture in rats

The Effect of Platelet Rich Plasma on Wound Healing in the Repair of Experimental Penile Fractures

Contact Info

Product

Resources

About

Histopathological effects of fibrin glue on penile fracture in a rat model

Abstract: Purpose: To evaluate both histopathological e ects and potential clinical application of brin glue on the penile cavernosal tissue.

Cited by 4 publications

References 25 publications

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Beneficial influence of topical extra virgin olive oil application on an experimental model of penile fracture in rats

​The Effect of Platelet Rich Plasma on Wound Healing in the Repair of Experimental Penile Fractures

Contact Info

Product

Resources

About

The Effect of Platelet Rich Plasma on Wound Healing in the Repair of Experimental Penile Fractures