Histopathological effects of pesticide-cholopyrifos on kidney in albino rats

Rekha, .; Raina, Sunanda; Hamid, Sajad

doi:10.5455/2320-6012.ijrms20131131

Cited by 37 publications

(20 citation statements)

References 22 publications

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“…Such liver damage may arise from the toxic effects of malathion, which disturbs the detoxification mechanisms of the liver. Similar findings to the current observations were reported earlier [30] in kidney tissue of rats administered with chlorpyrifos. The most notable effect of spinosad after subchronic exposure in rats is vacuolar degeneration [19].…”

Section: Discussionsupporting

confidence: 82%

“…Thus, the biochemical parameter data obtained from this study support this speculation in which malathion-and spinosad-treated rats showed alteration in the activities of AST and ALT. Histopathological lesions have been widely used as biomarkers for the health evaluation of organisms exposed to pollutants [30]. Histopathological biomarker in environmental monitoring is of significant advantage as it permits examining specific target organs which are responsible for vital functions.…”

Section: Discussionmentioning

confidence: 99%

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Hepato and Nephrotoxicity in Male Albino Rats Exposed to Malathion and Spinosad in Stored Wheat Grains

Zidan¹

2014

EJFSAT

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Adult male albino rats were fed on stored wheat grains (Triticum aestivum L.) treated with malathion and spinosad at both 8 and 16 ppm for 90 consecutive days to evaluate their hepatic and renal toxicity. The activity of serum acetylcholinesterase (AChE) was decreased in rats treated with the higher concentration of both tested pesticides. Biochemical parameters of liver functions [i.e., aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) activity, as well as total protein, albumin, bilirubin and cholesterol levels] were severely affected especially at higher concentration. Malathion and spinosad elevated the activity of ALT, AST, ALP and ACP in rats treated with the higher concentration. Also, total and direct bilirubin levels increased in rats treated with the higher concentration of both pesticides. On the contrary, both pesticides decreased total protein and albumin levels in treated rats in a concentration-dependent manner. Furthermore, malathion was found to be hyperglycemic. Kidney function parameters (i.e., urea and creatinine levels) were increased in treated rats in a concentration-dependent manner. The above mentioned effects were supported by histopathological examination of liver and kidney tissues. The obtained results indicated also that malathion was able to cause a more pronounced hepato-and renal toxicity in rats than spinosad.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Hepato and Nephrotoxicity in Male Albino Rats Exposed to Malathion and Spinosad in Stored Wheat Grains

Zidan¹

2014

EJFSAT

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“…The widespread use of OPs by public health and agricultural programs has led to severe environmental pollution [2, 3] that constitutes a significant potential health hazard because of the possibility of the acute or chronic poisoning of humans and animals [4]. …”

Section: Introductionmentioning

confidence: 99%

Impact of Exposure to Fenitrothion on Vital Organs in Rats

Abdel-Ghany

Mohammed

Anis

et al. 2016

Journal of Toxicology

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This study was designed to investigate the impact of oral administration of fenitrothion (10 mg/kg) on liver, kidney, brain, and lung function in rats. The effect was studied on days 7, 14, 21, 28, and 42. Our results have shown deterioration in liver function as evidenced by the elevation in serum ALT, AST, ALP, and bilirubin and reduction in albumin and hepatic glycogen. This was associated with a state of hyperglycemia and hyperlipidemia and increased prothrombin time, while hemoglobin content was reduced. In addition, the kidney function was reduced as indicated by the elevation in serum creatinine, uric acid, and BUN, while the serum levels of magnesium, potassium, and sodium were reduced. This study also showed an impairment in brain neurotransmitter (elevated 5-HT, glutamate, GABA, and reduced dopamine and norepinephrine level). This was associated with a reduction in the barrier capacity in brain and lung. Fenitrothion also caused a decrease in cholinesterase activity in serum, lung, and brain activity associated with a state of oxidative stress in all tested organs and hyperammonemia. These results support the hazards of pesticide use and shows the importance of minimizing pesticide use or discovering new safe pesticides.

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“…In the present study, several destructive changes were appeared in kidney section under LM and SEM observation as a result of STG treatment. Such destructive changes like parenchymal degeneration, swelling and individualization of tubular epithelial cells, glomerular proliferation, increased cytoplasmic granularity, focal necrosis as well as nuclear degeneration might be resulted from the inability of kidney cells to cope up with toxicant induced functional imbalances as were reported earlier (Benjamin et al, 2005;Rekha et al, 2013). Towards the end of STG exposure, the lumens of collecting tubules were appeared to be precipitated by hyaline cast causing atrophy of tubular cells.…”

Section: Discussionmentioning

confidence: 63%

Protective effect of Aloe vera and Bryophyllum pinnatum extracts against Smokeless tobacco induced nephrotoxicity in albino mice

Medhi¹,

Dutta²

2019

Asian J Pharm Pharmacol

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Objective: The present study was carried out with an objective to evaluate the protective effect of methanolic extract of Aloe vera Bryophyllum pinnatum leaf gel and leaf against smokeless tobacco Gutkha (STG) induced toxicity in the kidney of Albino mice.: The Swiss albino mice were divided into six (6) groups, among which Materials and Methods two groups were treated with 100mg/kg and 200mg/kg body weight doses of STG orally for 90 days. Another three groups of mice were given STG along with and leaf extracts singly (300 mg/kg) b. wt and in A. vera B. pinnatum combination (mixture of both plant in 1:1 proportion) at an interval of 10 hours. Changes in kidney were evaluated at histological (LM and SEM level) and biochemical (SOD, CAT and MDA) level by following standard procedures. Results: LM analysis of histological structure of kidney revealed swelling and individualization of tubular epithelial cells, glomerular proliferation along with atrophied and enlarged glomerulus in STG treated mice. SEM analysis of surface structure of kidney of STG treated animals showed heterogenous surface morphology with reduced, necrosed and individualized tubules of kidney. Significant (p<0.01) alterations were also observed in selected enzyme parameters of STG treated mice. However, such histological and biochemical changes were not observed in and A. vera B. pinnatum A. extract treated animals.: Result of the present study suggested the ameliorative potential of Conclusion vera B. pinnatum and methanolic extract against STG induced nephrotoxicity with more efficacy of combined mixture than their individual application.

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Histopathological effects of pesticide-cholopyrifos on kidney in albino rats

Cited by 37 publications

References 22 publications

Hepato and Nephrotoxicity in Male Albino Rats Exposed to Malathion and Spinosad in Stored Wheat Grains

Hepato and Nephrotoxicity in Male Albino Rats Exposed to Malathion and Spinosad in Stored Wheat Grains

Impact of Exposure to Fenitrothion on Vital Organs in Rats

Protective effect of Aloe vera and Bryophyllum pinnatum extracts against Smokeless tobacco induced nephrotoxicity in albino mice

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