Histopathological effects of titanium dioxide nanoparticles on the liver of Japanese quail Coturnix coturnix japonica

Abstract

Titanium dioxide nanoparticles have multiple beneficial uses, as they are used in many medical, industrial, economic, and other fields. Despite these many benefits, it is not without harm to humans and animals if used without control. Therefore, the present study aimed to discover the histopathological effects of Titanium dioxide nanoparticles on the liver of Japanese quail, Coturnix coturnix japonica. The study included three groups, the first group, the control group, which were dosed with distilled water for four continuous days, and the second and third experimental groups, which were dosed with Titanium dioxide nanoparticles at a concentration of 20 and 40 mg/kg, respectively. Four, fourteen, thirty and sixty days after the experiment began, the birds were sacrificed. The results showed the emergence of many histological lesions in the liver of birds of the two experimental groups, to varying degrees, in the four periods, among the most prominent tissue lesions that appeared in the second experimental group, the emergence of necrosis, hemorrhage, vacuolation, congestion, ballooning swelling, in addition to infiltration of inflammatory cells. While in the third experimental group, histopathological lesions appeared similar to second group, in addition to sinuses dilatation, Kupffer cells hypertrophy, hepatocyte enlargement, and necrosis of the walls of blood vessels and bile ducts. The study concluded that direct exposure to Titanium dioxide nanoparticles leads to damage to the liver tissue of these birds, which may affect its function and thus endanger its life.

Effects of Feeding Oak Acorn Flour on Hematology and Serum Biochemical Profile, and Carcass Characteristics of Japanese Quail

“…The results of the current study for blood analysis showed that the normal number of RBCs in quail birds was 3.18x10 6 /mm 3 , which agreed with the results of some authors [23,24], they recorded that the number of this type of blood cell was 3.8x10 6 /mm 3 , 3.2x10 6 /mm 3 , respectively. But this result was not agreed with the results obtained by [25], they mentioned that the total normal number of RBC was approximately 2x10 6 /mm3, and Deka and Borah [26], recorded the number was 4.04x10 6 /mm 3 for RBC. The current result also showed that the normal number of WBCs for quail birds in the control group was 5x10 3 / mm 3 , while many researchers [23,24,26] reported that the normal number for WBC ranges between 20-40x10 3 /mm 3 , 24x10 3 /mm 3 , and 3.77x10 3 /mm 3 respectively.…”

Bioceutical role of nano and organic selenium on certain reproductive value of laying hen during force molting

“…The measurements were taken with a Color digital camera HMDC-5 coupled to an optical microscope. This camera has built-in image analysis software (Scope image-0.9) to collect these measurements (15,16).…”