Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing

Ghorat, Fereshteh; Azizkhani, Mohammad; Naji, Shahriar; Ranjbary, Ali Ghorbani; Doostishoar, Farzad

doi:10.5812/ircmj.43788

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…Wild thyme has 1% oil of which a large part consists of phenols, monoterpene hydrocarbons, and alcohol. Wild thyme essence generally contains 25 compounds such as carvacrol (40.7%), thymol (26.9%), and γ -terpinene (7.3%) [ 21 , 22 ]. This research aimed to establish the protection role of T .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Thymus vulgaris on Hepatic Enzymes Activity and Apoptosis-Related Gene Expression in Streptozotocin-Induced Diabetic Rats

Azimi

Mehrzad

Ahmadi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Many diseases, including diabetes, are involved in the development of liver disorders through changes in the expression of genes such as apoptosis-related genes. In the present study, the effect of Thymus vulgaris (T. vulgaris) on hepatic enzyme activity and apoptosis-related gene expression in streptozotocin (STZ)-induced diabetic rats was examined. In this study, 50 adult male Wistar rats weighing approximately 200–220 g were divided into five groups. Diabetes was induced by an intraperitoneal injection of STZ (60 mg/kg). Following 18 days, all the animals in different groups were weighed and blood samples were taken from their cardiac veins. Gas chromatography-mass spectrometry (GC-MS) analysis revealed 45 different compounds in the T. vulgaris, including thymol (39.1%), p-cymene (20.63%), and γ-terpinene (14.85%). The results showed a significant increase in liver enzymes (aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)) in diabetic or STZ mice compared to the control group (healthy mice) ( P < 0.0001 ). The levels of AST, ALT, and ALP in rats treated with 200 mg/kg and 400 mg/kg of T. vulgaris extract showed a significant decrease in these enzymes in comparison with diabetic rats ( P < 0.0001 ). The expression of caspase 3 and 9 genes in the groups treated with thyme significantly decreased compared to diabetic mice ( P < 0.0001 ), and the expression of B-cell lymphoma-2 (Bcl-2) in the group receiving 400 mg/kg of thyme significantly increased compared to diabetic mice ( P < 0.0001 ). Due to its antioxidant compounds, thyme improves the liver tissue cells in STZ-induced diabetic mice by reducing caspases 3 and 9 as well as increasing Bcl-2.

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Section: Introductionmentioning

confidence: 99%

The Effect of Thymus vulgaris on Hepatic Enzymes Activity and Apoptosis-Related Gene Expression in Streptozotocin-Induced Diabetic Rats

Azimi

Mehrzad

Ahmadi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…As well as for endogenous therapy Arctium species have been used in traditional medicine for various skin conditions including eczema psoriasis, rashes, boils and etc.) [19].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effect of extract from root of Arctium tomentosum Mill. (woolly burdock) against several reference strains

Aitynova

Ibragimova²,

Shalakhmetova

et al. 2022

IJBCh

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Microorganisms are one of the main reasons for infectious diseases, however conditionally pathogenic ones are members of the normal human microbiome. Certain circumstances make them become pathogenic to organism. Treatment of microbial diseases majorly is carried out by antibiotics, using of which may lead to antibiotic resistance. Moreover, it causes deficiency of gut microflora, subsequent dysbiosis and weakening of immunity. Thus, replacement of antibiotics by naturally derived medicinal drugs will be an optimal way of fighting pathogenic microorganisms. Since plants are rich in various biologically active compounds, extracts from them will exert antimicrobial, anti-inflammatory, antioxidant properties and etc. In this investigation extract from Arctium tomentosum Mill. obtained by supercritical carbon dioxide extraction was studied for antimicrobial effect. Four reference microbial strains, including gram positive (Staphylococcus aureus), gram negative (Staphylococcus epidermidis, Escherichia coli) and fungi (Candida albicans) were treated. Ampicillin, Chloramphenicol and Nystatin were used for positive control. Procedure of antimicrobial assay was carried out by the method of two-fold serial dilutions in corresponding nutrient medium. As a result minimum bactericide and fungicide concentrations of the extract from A. tomentosum Mill. were determined. Against S. aureus it was 10.4 mg/ml and 41.7 mg/ml against S. epidermidis, while against E. coli it was 20.8 mg/ml. Minimum fungicidal concentration was 5.2 mg/ml. Also ranges of concentration of the studied extract that stop reproduction and development of selected microorganisms were determined. Thus, concentration range of bacteriostatic activity for S. aureus was 2.6-5.2, while for S. epidermidis was 2.6-20.8 mg/ml. Bacteriostatic activity of the studied extract against E.coli was not observed, however concentration range of fungistatic activity was 1.3-2.6 mg/ml. Obtained results show that extract from Arctium tomentosum Mill. has antimicrobial activity, so it can serve as a base for formation of phytopreparate for the treatment of diseases with microbial origin.

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“…The antioxidant and the anti-inflammatory activity of A. lappa leaves, fruits, and roots, as well as individual compounds isolated from them, has been confirmed in studies in cell-free systems, on specific cell lines and using animal models [ 22 , 23 , 24 , 25 ]. It has been shown that the extract from greater burdock roots significantly reduced the time of regeneration of damaged skin [ 26 , 27 ]. A. lappa leaf extract affects the regulatory activity of melanogenesis by inhibiting melanin secretion [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots

Skowrońska

Granica

Dziedzic

et al. 2021

Plants

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Arctium lappa is a weed used in traditional medicine in the treatment of skin inflammation and digestive tract diseases. Arctium tomentosum is used in folk medicine interchangeably with Arctium lappa and, according to European Medicines Agency (EMA) monography, provides an equal source of Arctii radix (Bardanae radix), despite the small amount of research confirming its activity and chemical composition. The aim of the study was the comparison of the anti-lipoxygenase and the antioxidant activity, scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion (O2•−), and hydrogen peroxide (H2O2), of 70 % (v/v) ethanolic extracts from the aerial parts and the roots of Arctium lappa and Arctium tomentosum. In the tested extracts, the total polyphenols content and the chemical composition, analyzed with the HPLC–DAD–MSn method, were also compared. The extracts were characterized by strong antioxidant properties, but their ability to inhibit lipoxygenase activity was rather weak. A correlation between the content of polyphenolic compounds and antioxidant activity was observed. The extracts from A. lappa plant materials scavenged reactive oxygen species more strongly than the extracts from A. tomentosum plant materials. Moreover, the extracts from A. lappa plant materials were characterized by the statistically significantly higher content of polyphenolic compounds.

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Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing

Cited by 8 publications

References 20 publications

The Effect of Thymus vulgaris on Hepatic Enzymes Activity and Apoptosis-Related Gene Expression in Streptozotocin-Induced Diabetic Rats

The Effect of Thymus vulgaris on Hepatic Enzymes Activity and Apoptosis-Related Gene Expression in Streptozotocin-Induced Diabetic Rats

Antimicrobial effect of extract from root of Arctium tomentosum Mill. (woolly burdock) against several reference strains

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots

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