Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

Rahman, Atiqur; Biswas, Mamun Ali; Siddika, Syeda Tasfia; Sikder, Abdul Mannan

doi:10.3329/jemc.v2i1.11915

Cited by 4 publications

(8 citation statements)

References 16 publications

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“…12 In the study by Kamat G C et al 13 the rates of non-Hodgkin lymphoma to Hodgkin lymphoma was 8:1 which was similar to that found in the present study. In another study by Rahman M A et al 14 reactive hyperplasia comprised (30.89%), (which was higher than that found in the present study), tuberculosis lymphadenitis (33.5%), non-caseous granuloma (1.05%) and miscellaneous non-neoplastic conitions (4.7%). Among the neoplastic lesions 17.28% were lymphomas which included 22cases (11.52%) of nonHodgkin's lymphoma and 11 cases (5.76%) of Hodgkin lymphoma giving a ratio of NHL: HL of 2:1 which differs from the present study (NHL: HL= 8:1).…”

Section: Discussioncontrasting

confidence: 48%

Histopathological study of Lymph node lesions

Vidyadhar¹,

S²,

K³

2014

JIMD

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Abstract:Lymph node biopsy and histopathological examination (HPE) is an extremely important investigation helpful in differentiating between reactive and neoplastic states including lymphomas, sarcomas, histiocytosis and leukemias. Lymph node biopsy is also helpful in differentiating between primary and secondary malignant lesions of the lymph node. The present study was carried out in the Department of Pathology, Kannur Medical College, Kannur, on patients with clinically palpable lymph nodes i.e. either localised or generalised lymphadenopathy. The cervical lymph node was excised in preference to axillary and inguinal nodes. Among the non-neoplastic lesions tuberculous lymphadenitis (34.2%) and among the neoplastic lesions, metastatic carcinomas (19.90%) were the most common. Lymphomas comprised approximately 4% of the cases. Non-neoplastic lesions were most common in the 20-30 year age group whereas neoplastic lesions were most common in the 51-60 year age group. HPE on properly selected and excised lymph nodes enables one to arrive at an accurate diagnosis.

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Section: Discussioncontrasting

confidence: 48%

Histopathological study of Lymph node lesions

Vidyadhar¹,

S²,

K³

2014

JIMD

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“…In the study by Mbata GC et al 11 , there was a predominance of metastatic neoplasms among the malignancies. However, lymphomas were found to be more common in other studies by Atiqur Rahman et al 12 , Kasturi et al 9 and Abdul Ghafoor et al In our study, there was a significant relationship between histopathological diagnosis and the size of lymphadenopathy. Out of all the malignant causes of lymphadenopathy, 54.5% of malignancies had lymphadenopathy ≥2 cm while in the case of lymphadenopathy due to non-neoplastic lesions, only 24.5% of cases had lymphadenopathy ≥2 cm.…”

Section: Methodscontrasting

confidence: 46%

“…In the present study, abdominal lymph nodes and cervical lymph nodes gave the highest diagnostic yield (90% and 88% respectively), while axillary lymph nodes gave the lowest diagnostic yield (75%). In a study by Atiqur Rahman et al 12 , abdominal and axillary lymph nodes gave the highest diagnostic yield (67.9%), while submental and submandibular lymph nodes gave poor diagnostic yield. This might be because there were only fewer biopsies taken from the submental and submandibular regions in the given study.…”

Section: Methodsmentioning

confidence: 94%

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Histomorphological patterns of lesions in lymph node biopsies

Bibi¹,

Ali²,

Niazi³

2021

JRMC

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Introduction: Lymph node biopsies are routinely performed for the evaluation of lymphadenopathies. Tuberculosis and other infections are the major causes of lymphadenopathy in developing countries. The pattern of lymph node enlargement is different for different age groups. Malignancies are common in adults as compared to children.Objective: To document the incidence of diseases causing lymphadenopathy along with the demographics of the population under study, and to correlate site and size of lymphadenopathy with the histopathological diagnosis.Materials and Methods: A total of 163 patients whose lymph nodes biopsies were performed from January 2015 to June 2018 were included in the study. All demographic and laboratory data were recorded on a proforma and analyzed using SPSS version 22.Results: A total of 163 biopsies were studied with ages ranging from 03 to 96 years. Female patients were 57.05% and male patients 42.94%. In the studied cases, 74.84% were found to be non-neoplastic, 13.5% neoplastic while 11.65% of cases biopsies were either unremarkable or non-lymphoid tissue was biopsied. Reactive hyperplasia was the commonest lesion accounting for 50.3% of cases, followed by tuberculosis (23.3%), metastatic carcinoma (6.2%), lymphoproliferative disorders (1.84%), Hodgkin’s lymphoma (3%), non-Hodgkin’s lymphoma (2.45%) and non-caseating granulomatous lymphadenitis (1.22%) respectively. Lymph node size was found to be greater than 2cm in only 25.7% of cases.Conclusion: Reactive hyperplasia and tuberculosis are the most common diagnosis in lymph node biopsies. Lymph node biopsy is a diagnostic and reliable histologic investigation to differentiate non-neoplastic lesions from neoplastic lesions, and further classify the disease based on microscopic findings in both cases.

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“…These results were similar with the results reported by other studies where female dominance was seen. 1,3,5,9,10 Almost 65% of the total lymph node biopsies were of tuberculous lymphadenitis which was the most common finding reported. Similar findings have been obtained from some tropical and developing countries.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the histopathological findings of lymph node biopsies at a tertiary care centre

et al. 2023

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Background: Lymph nodes are spread throughout the body and are routinely checked for abnormalities. These lymph nodes have the potential to become infected or malignant. The swelling of lymph nodes and the nodes which are abnormal in terms of size and/or number is commonly known as lymphadenopathy. One of the most common causes of lymphadenopathy observed is reactive lymphadenitis followed by granulomatous lymphadenitis. For diagnosis of lymph node biopsies, excisional biopsy and histopathological analysis are considered as the ‘gold standard’. Methods: This is a retrospective, descriptive and a cross-sectional study of all the patients with lymph node biopsies seen in Bhaktivedanta Hospital and Research Institute from January 2018 till March 2022. Histopathology reports of lymph node biopsies of patients required at Bhaktivedanta Hospital and Research Institute were included in the study. Results: The most common diagnosis is of tuberculous lymphadenitis which accounted for 251 (53.2%) of the total 469 cases. Tuberculous lymphadenitis was most commonly observed in females (68.92%) as compared to males (31.07%). Cancer cases which accounted for 83 (17.70%) cases formed the second most common diagnosis in which females (53.01%) accounted for most cases as compared to males (46.99%). Conclusions: Enlarged lymph nodes should undergo fine needle aspiration cytology (FNAC), truecut biopsy and/or excisional biopsy for correct diagnosis. The diagnostic spectrum ranges from benign reactive to TB and also malignancies.

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Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

Cited by 4 publications

References 16 publications

Histopathological study of Lymph node lesions

Histopathological study of Lymph node lesions

Histomorphological patterns of lesions in lymph node biopsies

Analysis of the histopathological findings of lymph node biopsies at a tertiary care centre

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