Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model

Gürses, İclal; Özeren, Murat; Serin, M.; Yücel, Neslihan; Erkal, Haldun Şükrü

doi:10.1016/j.prp.2014.08.006

Cited by 61 publications

(32 citation statements)

References 26 publications

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“…It is reported that perivascular fi brosis of intramural arterioles, thickening of preexisting collagen fi bers and an increase in the number of fi bers could be seen between viable myocytes after the radiation exposure (20). We saw the same observation similar to our previous study (21), namely that myocardial fi brosis started from the perivascular area and then progressed into the interstitial fi eld among the myofi brils. In the set of mesh confi guration, severe myocardial fi brosis was seen at apex of the heart; tip of papillary muscles and in areas where the ventricle wall was adjacent to the atrioventricular valves.…”

Section: Fibrosissupporting

confidence: 89%

Histopathological efficiency of amifostine in radiation‑induced heart disease in rats

Gürses¹,

Özeren²,

Serin³

et al. 2018

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OBJECTIVE: Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long-term protective effect on heart tissue in an experimental rat model. METHODS: Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. A dose of 200 mg/kg of amifostine was injected intraperitoneally 30 min prior to radiation exposure. Analyses were performed 6 months after irradiation. RESULTS: Vascular damage and vasculitis were signifi cantly decreased in amifositine treatment group. At the same time, signifi cant thickening of the medial layer was accompanied by vascular damage in irradiated groups. The number and severity of myocyte necrosis were diminished with amifostine. Nevertheless, it could not prevent epicardial and myocardial fi brosis. Severe myocardial fi brosis was observed prominently in three regions, particularly on the apex, tips of papillary muscles and in sites adjacent to the atrioventricular valves. The anti-infl ammatory effect of amifostine was not seen. CONCLUSION: The development of vascular damage and vasculitis were prevented by the use of amifostine. There was a correlation between vascular damage and fi brosis development. According to histopathological results, amifostine could be used as a protective agent against the side effects of radiotherapy (Tab. 4, Fig. 2, Ref. 22). Text in PDF www.elis.sk.

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Section: Fibrosissupporting

confidence: 89%

Histopathological efficiency of amifostine in radiation‑induced heart disease in rats

Gürses¹,

Özeren²,

Serin³

et al. 2018

BLL

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“…Moreover, melatonin has been reported to protect cardiomyocytes and blood vessels against fibrosis necrosis and vasculitis in radiation-induced heart disease in rats when administrated at 50 mg/kg [254]. Furthermore, melatonin was demonstrated to dose-dependently reduce flow shear stress-induced injury in bone marrow mesenchymal stem cells (BM-MSCs) through the activation of melatonin receptors and adenosine monophosphate activated protein kinase (AMPK)/ACC (acetyl-CoA carboxylase) signaling, which could benefit the patients with valvular heart disease [255].…”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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“…The administration of melatonin can prevent or ameliorate chronic inflammation and oxidative damage, fibrosis, necrosis, thrombus, vascular damage, and increased numbers of immune cells in various tissues, such as heart, lung, parotid and submandibular glands, kidneys, spinal cord, the lens, genitourinary system, and others (Karslioğlu et al 2005;Canyilmaz et al 2016;Cakmak Karaer et al 2016;Gürses et al 2014;Haddadi et al 2013;Serin et al 2007;Şener et al 2004;Tahamtan et al 2015). Prevention of pathological damage induced by ionizing radiation using melatonin at different times before and after exposure is a promising outcome.…”

Section: Effect Of Melatonin On Chronic Immune Responses Induced By Imentioning

confidence: 99%

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

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Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs. These effects are mediated through various modulatory effects of melatonin in different levels of tissue reaction to ionizing radiation. The effects on the DNA repair system, antioxidant enzymes, immune cells, cytokines secretion, transcription factors, and protein kinases are most important. Moreover, anti-cancer properties of melatonin may increase the therapeutic ratio of radiotherapy. Clinical applications of this agent for the management of malignancies such as breast cancer have shown promising results. It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of melatonin that may help to improve response of the tumor to radiotherapy. In this review, the effects of melatonin on the modulation of immune responses in both normal and tumor tissues will be discussed.

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Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model

Cited by 61 publications

References 26 publications

Histopathological efficiency of amifostine in radiation‑induced heart disease in rats

Histopathological efficiency of amifostine in radiation‑induced heart disease in rats

Dietary Sources and Bioactivities of Melatonin

The melatonin immunomodulatory actions in radiotherapy

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