Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

Durmuş, Kasım; Turgut, Nergiz Hacer; Doğan, Mehtap; Tuncer, Ersin; Özer, Hatice; Altuntaş, Emine Elif; Akyol, Melih

doi:10.17219/acem/65477

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Attempts have been made to administer strontium ranelate locally in the form of an injection, which has also brought about beneficial results [ 44 ]. Other attempts have been made to introduce the drug substance SrRan together with titanium implants [ 45 ], but the results were found to be inconclusive.…”

Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

166

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Osteoporosis is a chronic disease characterized by low bone mass caused by increased bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or anabolic drugs, which usually have a unidirectional effect, i.e., they inhibit the activity of osteoclasts or stimulate the effect of osteoblasts. Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a multidirectional effect on bone tissue, intensifying osteoblastogenesis while inhibiting osteoclastogenesis. It turns out that this effect is demonstrated by strontium ions, an element showing physical and chemical similarity to calcium, the basic element that builds the mineral fraction of bone. As a result, strontium acts through the calcium-sensing receptor (CaSR) receptor in bone tissue cells. In recent years, there has been a significant increase in interest in the introduction of strontium ions in place of calcium ions in ceramics used as bone replacement materials for the treatment of bone fractures and defects caused by osteoporosis. The aim of this study was to summarize current knowledge about the role of strontium in the treatment of osteoporosis, its effects (in various forms), and the ways in which it is administered.

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Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

166

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“…Sr-ranelate (SrR) is widely used as an effective treatment for osteoporosis and found to enhance bone formation and increase overall bone quality and mineral density [ 40 ]. Despite all these advantages, prolonged oral administration of SrR was found to increase the risk of a cardiovascular infarction, and many studies proved that local administration of Sr 2+ is more beneficial [ 41 , 42 , 43 ]. Recently, with the emergence of BTE and biomaterials in the treatment of bone diseases, Sr-enriched biomaterials showed an advantageous effect that allowed local Sr delivery, reducing the side effects [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Inhibition and Osteogenic Potentials of Sr/Zn Co-Doped Nano-Hydroxyapatite-PLGA Composite Scaffold for Bone Tissue Engineering Applications

et al. 2023

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Bacterial infection associated with bone grafts is one of the major challenges that can lead to implant failure. Treatment of these infections is a costly endeavor; therefore, an ideal bone scaffold should merge both biocompatibility and antibacterial activity. Antibiotic-impregnated scaffolds may prevent bacterial colonization but exacerbate the global antibiotic resistance problem. Recent approaches combined scaffolds with metal ions that have antimicrobial properties. In our study, a unique strontium/zinc (Sr/Zn) co-doped nanohydroxyapatite (nHAp) and Poly (lactic-co-glycolic acid) -(PLGA) composite scaffold was fabricated using a chemical precipitation method with different ratios of Sr/Zn ions (1%, 2.5%, and 4%). The scaffolds’ antibacterial activity against Staphylococcus aureus were evaluated by counting bacterial colony-forming unit (CFU) numbers after direct contact with the scaffolds. The results showed a dose-dependent reduction in CFU numbers as the Zn concentration increased, with 4% Zn showing the best antibacterial properties of all the Zn-containing scaffolds. PLGA incorporation in Sr/Zn-nHAp did not affect the Zn antibacterial activity and the 4% Sr/Zn-nHAp-PLGA scaffold showed a 99.7% bacterial growth inhibition. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability assay showed that Sr/Zn co-doping supported osteoblast cell proliferation with no apparent cytotoxicity and the highest doping percentage in the 4% Sr/Zn-nHAp-PLGA was found to be ideal for cell growth. In conclusion, these findings demonstrate the potential for a 4% Sr/Zn-nHAp-PLGA scaffold with enhanced antibacterial activity and cytocompatibility as a suitable candidate for bone regeneration.

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“…Despite advances in maxillofacial surgery, impaired bone healing remains a concern for surgical teams 2 . Mandibular fractures are among the most common of the maxillofacial region, accounting for 23% to 97% of all facial fractures 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

The effect of two phosphodiesterase inhibitors on bone healing in mandibular fractures (animal study in rats)

MalekiGorji

Golestaneh

Razavi

2020

JKAOMS

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Objectives: Despite advances in maxillofacial surgery, impaired bone healing remains a concern for surgical teams. Many studies have evaluated the effects of sildenafil and pentoxifylline on bone healing. However, their effects on healing of bone fractures have not been well investigated. This study aimed to assess the effects of the phosphodiesterase inhibitors sildenafil and pentoxifylline on healing of mandibular fractures in rats. Materials and Methods: A total of 60 rats were randomly divided into six groups of 10. Mandibular fracture was induced in all rats. After the surgical procedure, group C1 received saline, group S1 received 10 mg/kg sildenafil and group P1 received 50 mg/kg pentoxifylline. The rats were sacrificed after 1 week. Groups C4, S4, and P4 received pharmaceutical therapy as in groups C1, S1, and P1 but were sacrificed after 4 weeks. The samples then underwent histological analysis. Results: The mean rate of bone healing of mandibular fractures in groups S1 and P1 was significantly higher than in group C1 at 1 week (P<0.001). The mean rate of bone healing of mandibular fractures in group P1 was higher than in group S1 at 1 week (P=0.04). The mean rate of bone healing of mandibular fractures in groups S4 (P=0.001) and P4 (P=0.004) was significantly higher than in group C4 at 4 weeks, but no significant difference was noted in the rate of healing between groups P4 and S4 (P=0.53). Conclusion: Sildenafil and pentoxifylline can be used as adjuncts to enhance bone healing in rats.

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Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

Cited by 4 publications

References 29 publications

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Bacterial Inhibition and Osteogenic Potentials of Sr/Zn Co-Doped Nano-Hydroxyapatite-PLGA Composite Scaffold for Bone Tissue Engineering Applications

The effect of two phosphodiesterase inhibitors on bone healing in mandibular fractures (animal study in rats)

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