Histopathological Features of Atrophic Thyroiditis with Blocklng Type-TSH Binding Inhibitor Immunoglobulins.

Sugenoya, Akira; Itoh, Nobuo; Kasuga, Yoshio; Kobayashi, Shinya; Ohhashi, Tohjiro; Nagai, Noriyoshi; Iida, Futoshi

doi:10.1507/endocrj.42.277

Cited by 8 publications

(7 citation statements)

References 9 publications

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Section: Thyroid Cancer and Autoimmune Thyroiditis-general Featuresmentioning

confidence: 99%

“…They predominate in females, show high serum anti-thyroid antibody titers, and have a chronic or transient clinical course depending on their setting of presentation [18][19][20][21][22][23]. Atrophic thyroiditis (primary myxedema) is characterized by the existence of serum TSH receptor-blocking antibodies and, on histology, the thyroid gland shows atrophic follicles with or without some oxyphil cell changes, fibrosis, and mild focal lymphoid infiltrates [23,24]. The other types of autoimmune thyroiditis reveal serum anti-thyroglobulin and anti-thyroid peroxidase antibodies and, on histology, show a full spectrum of histological features ranging from focal to diffuse or Hashimoto's thyroiditis [18][19][20][21][22]24].…”

Section: Thyroid Cancer and Autoimmune Thyroiditis-general Featuresmentioning

confidence: 99%

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Thyroid Cancer, Thyroiditis and Dietary Iodine: A Review Based on the Salta, Argentina Model

Harach

Ceballos

2008

Endocr Pathol

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Factors that should be considered when studying the effect of dietary iodine in the development of thyroid cancer include pathological criteria, diagnostic techniques, screening programs, radioactive fallout, and standard of medical care in the studied population. In most surveys, papillary carcinoma forms the largest group of thyroid malignancies, both before and after iodine prophylaxis where an increase in the papillary:follicular carcinoma ratio is also noted. Undifferentiated carcinomas decrease after salt prophylaxis. In Salta, Argentina, the increasing incidence of clinically significant papillary thyroid cancer and the decrease of undifferentiated carcinoma after iodine prophylaxis are probably due to better access to health centers and consequent earlier detection of differentiated precursor tumors. Autoimmune focal and diffuse or Hashimoto's thyroiditis are linked to dietary iodine. Pathological studies made in different regions indicate that these types of thyroiditis occur more frequently in areas of iodine sufficiency than in areas of iodine deficiency, and increase after iodine prophylaxis both in non-goitrous and iodine-deficient areas like Salta, Argentina. An increase of lymphocytic thyroiditis could be linked to an increased incidence of primary thyroid lymphoma, and thyroiditis is more commonly associated with papillary carcinoma than with other types of thyroid follicular or C-cell derived carcinomas regardless of iodine intake.

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Section: Thyroid Cancer and Autoimmune Thyroiditis-general Featuresmentioning

confidence: 99%

Section: Thyroid Cancer and Autoimmune Thyroiditis-general Featuresmentioning

confidence: 99%

Thyroid Cancer, Thyroiditis and Dietary Iodine: A Review Based on the Salta, Argentina Model

Harach

Ceballos

2008

Endocr Pathol

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“…The histopathological features of atrophic thyroiditis with TSBAb showed that follicles were noticeably atrophic with epithelial flattening, and that lymphoid follicle formation was scarce [19]. Although the follicles with flattened epitheliums in the present cases resembled atrophic thyroiditis with TSBAb, the histopathological features were not inconsistent with chronic thyroiditis.…”

Section: Interferonmentioning

confidence: 41%

Two Cases of Transiently TSBAb-Positive Hypothyroidism Induced by Interferon-Alpha Therapy for Chronic Hepatitis C.

et al. 1997

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Abstract.A 34-year-old woman and a 54-year-old woman were treated with interferon-alpha (IFN-a) for chronic hepatitis C. Three months after the cessation of the IFN-a therapy, each patient developed hypothyroidism with the presence of thyroid-stimulation-blocking antibody (TSBAb) and TSH-binding inhibitor immunoglobulin (TBII). These two patients were treated with thyroxin, and both TSBAb and TBII activities gradually decreased. Although both TSBAb and TBII became negative several months after the start of the replacement therapy, the replacement dosage of L-thyroxine could not be reduced. Thyroid biopsies showed that the follicular epitheliums were flattened in both cases with lymphocytic infiltration.These findings suggest that IFN-a may induce hypothyroidism and the transient emergence of TSBAb and TBII.

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“…His thyroid function remained within the normal range without subsequent replacement therapy. It was suspected that TSBAb did not disturb the organogenesis of the thyroid gland or destroy the gland [8].…”

Section: Discussionmentioning

confidence: 99%

Clinical Courses and Thyroid Conditions in Three Infants Born to a Mother with Thyroid Stimulating-Blocking Antibodies.

et al. 1997

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Abstract.The clinical courses including thyroid conditions of three infants born to a mother with primary hypothyroidism due to Hashimoto's thyroiditis were studied. The mother was positive for both TSH-binding inhibitor immunoglobulins (TBII) and thyroid stimulating-blocking antibodies (TSBAb) in her serum.The first infant died because of septic shock due to fistula formation between the large intestine and the bladder.Serum thyroid hormone levels during the first pregnancy were extremely low because of incomplete replacement therapy with levothyroxine.

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Histopathological Features of Atrophic Thyroiditis with Blocklng Type-TSH Binding Inhibitor Immunoglobulins.

Cited by 8 publications

References 9 publications

Thyroid Cancer, Thyroiditis and Dietary Iodine: A Review Based on the Salta, Argentina Model

Thyroid Cancer, Thyroiditis and Dietary Iodine: A Review Based on the Salta, Argentina Model

Two Cases of Transiently TSBAb-Positive Hypothyroidism Induced by Interferon-Alpha Therapy for Chronic Hepatitis C.

Clinical Courses and Thyroid Conditions in Three Infants Born to a Mother with Thyroid Stimulating-Blocking Antibodies.

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