Histopathological features of flexural melanocytic nevi: a study of 40 cases

Rongioletti, Franco; Ball, Russell A.; Marcus, Rosilyn; Barnhill, Raymond L.

doi:10.1034/j.1600-0560.2000.027005215.x

Cited by 68 publications

(39 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is now very well known that nevi developed on special sites can have important architectural alterations evoking a form of melanoma [43,118]. The 'special sites' are mostly along the mammary line (axilla, breast, genital area).…”

Section: Nevus On Special Sitesmentioning

confidence: 99%

Melanocytic nevi simulant of melanoma with medicolegal relevance

Massi

2007

Virchows Arch

View full text Add to dashboard Cite

A group of melanocytic benign nevi are prone to be misdiagnosed as nodular or superficial spreading melanoma. This review illustrates the most frequent forms of these nevi in direct comparison with their malignant morphologic counterparts. The nevi are: hyper-cellular form of common nevus to be distinguished from nevoid melanoma, Spitz nevus (vs spitzoid melanoma), Reed nevus (vs melanoma with features of Reed nevus), cellular atypical blue nevus (vs melanoma on blue nevus), acral nevus (vs acral melanoma), Clark dysplastic nevus (vs superficial spreading melanoma), desmoplastic nevi (vs desmoplastic melanoma), benign proliferative nodules in congenital nevi (vs melanoma on congenital nevi), epithelioid blue nevus (vs animal type melanoma) and regressed nevus (vs regressed melanoma). For each single 'pair' of morphological look-alikes, a specific set of morphological, immunohistochemical and genetic criteria is provided.

show abstract

Section: Nevus On Special Sitesmentioning

confidence: 99%

Melanocytic nevi simulant of melanoma with medicolegal relevance

Massi

2007

Virchows Arch

View full text Add to dashboard Cite

show abstract

“…46,47 Another is the histologic appearance of nevi of peculiar anatomic sites (ie milk line, flexural, auricular, genital, or acral nevi). 33,48,49 All may generate a histomorphology suspicious for melanoma. 50 Other potential pitfalls for overdiagnosis include the pigmented spindle cell nevus and the combined nevus, including in the context of the deep penetrating nevus.…”

Section: Overdiagnosismentioning

confidence: 99%

Medicolegal aspects of neoplastic dermatology

Crowson

2006

Modern Pathology

View full text Add to dashboard Cite

Medical malpractice litigation is rising at an explosive rate in the US and, to a lesser extent, in Canada. The impact of medical malpractice litigation on health care costs and the cost of insurance is dramatic. Certain specialist categories are becoming uninsurable in some parts of the US, while in others, clinicians are retiring early, restricting or changing practice or changing states of residence in consequence of medical malpractice claims and of the cost and availability of insurance. This, in turn, has had the real effect of denying care to patients in some communities in the US. Some 13% of all medical malpractice claims relate to one area of neoplastic dermatopathology, specifically, melanocytic neoplasia. Certain steps can be taken by pathology laboratories to reduce, but never completely eliminate, the risk of medical malpractice claims. In this review, attention is paid to the source of medical malpractice claims and an abbreviated approach to specific strategies for risk management is presented.

show abstract

“…One such recently recognized site involves nevi of flexural skin. 61 Such nevi may show greater variability in the size of junctional nests as well as origin of nests at the edges of rete as well as in inter-rete regions, both features that also occur in dysplastic nevi (Figures 12-14). However, cytologic atypia and associated stromal alterations typical of dysplastic nevi are said to be lacking in nevi of the flexural type.…”

Section: Nevi Of Flexural Skinmentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

View full text Add to dashboard Cite

Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma. Nevi are the most important simulants of melanoma, both clinically and histologically, and can usually be reliably distinguished from melanomas using published criteria. Some lesions are characterized by greater degrees of atypia and may be more difficult to diagnose. Dysplastic nevi are among the most important simulants of melanoma. Nevi may also be important as potential precursors of melanoma; however, most nevi are stable and will not progress to malignancy. Nevi are vastly more common than melanomas and the rate of progression of individual lesions is very low. Therefore, nevi are not as a rule managed by wholesale excision to prevent melanoma. Nevi are also important as risk markers, identifying individuals at greater risk of developing melanoma in the future. Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers. Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma. However, they are not risk markers and they are not malignancies. Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'. It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment. Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy. In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma.

show abstract

Histopathological features of flexural melanocytic nevi: a study of 40 cases

Cited by 68 publications

References 1 publication

Melanocytic nevi simulant of melanoma with medicolegal relevance

Melanocytic nevi simulant of melanoma with medicolegal relevance

Medicolegal aspects of neoplastic dermatology

Precursors to melanoma and their mimics: nevi of special sites

Contact Info

Product

Resources

About