Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia

Santana, Thalita; Nagata, Gabriela Sanchez; Saturno, Juvaní Lago; Trierveiler, Marília

doi:10.1111/cup.13677

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…In our series, the lip vermilion was the most frequently affected site, a location that indicates a relation with exposure to ultraviolet radiation (UV) from the Sun. In total, 15 out of 199 cases were associated with the potentially malignant disorder actinic cheilitis, a condition known to be related to chronic exposure to UV radiation (Santana et al, 2020). Thus, the number of melanotic macules in the lip vermilion may be underestimated as several cases were probably diagnosed as actinic cheilitis, which is more clinically relevant.…”

Section: Discussionmentioning

confidence: 99%

Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study

et al. 2023

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ObjectiveThis study aimed to analyse the clinical and histopathological characteristics of focal oral melanocytic lesions in a Brazilian reference service in Oral and Maxillofacial Pathology.Materials and MethodsA cross‐sectional study was conducted over an 18‐year period. Demographic data and clinical features were collected from the archives, and all biopsy specimens diagnosed as oral melanocytic lesions were retrieved and reviewed.ResultsWe identified 339 melanocytic lesions. Of these, 191 were melanotic macules, 112 melanocytic nevi, 14 mucosal lentigo simplex, 12 melanomas, 9 solar lentigos, and 1 melanoacanthoma. Lesions occurred mostly in white‐skinned (74.2%) women (65.2%). The main reported clinical aspect was the macule (67.4%), and the most affected site was the lip vermilion (25.4%), followed by the palate (22.9%). Melanomas were larger in size and were observed in older patients with an overall shorter time of onset. The most frequent subtypes of melanocytic nevi were intramucosal (44.6%), compound (24.1%), and blue nevus (20.5%). They showed a heterogeneous architectural pattern with the presence of the three cell types.ConclusionThe most frequent lesions are melanotic macule and nevus, especially the intramucosal subtype. Patients are usually white‐skinned women presenting a small, long‐lasting, macular lesion on the lip vermilion or palate.

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Section: Discussionmentioning

confidence: 99%

Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study

et al. 2023

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“…The mast cells were identified and counted randomly via light microscopy at a ×40 magnification with an E600 microscope (Eclipse E-600; Nikon Corporation). The average numbers of mast cells per section per group were determined ( 23 ).…”

Section: Methodsmentioning

confidence: 99%

CD4⁺/IL‑4⁺lymphocytes of the lamina propria and substance P promote colonic protection during acute stress

et al. 2021

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Life stress may influence symptom onset and severity in certain gastrointestinal disorders in association with a dysregulated intestinal barrier. It has been widely accepted that stress triggers the hypothalamus-pituitary-adrenal (HPA) axis, releasing corticosterone, which promotes intestinal permeability. In response, colonic inflammation alters mucosal immune homeostasis and destroys the colonic architecture, leading to severe intestinal diseases. Endogenous substance P (SP) does not inhibit the initial extent of the HPA axis response to restraint stress, but it reduces the duration of the stress, suggesting that SP plays an important role in the transition between acute and chronic stress. The present study aimed to investigate the effect of two groups of mice exposed to stress, including acute and chronic stress. The corticosterone was evaluated by ELISA, colon samples were obtained to detected polymorphonuclear cells by hematoxylin and eosin staining, goblet and mast cells were identified by immunocytochemistry and cytokine-producing CD4 + T cells were analyzed by flow cytometry assays, adhesion proteins in the colon epithelium by western blotting and serum SP levels by ELISA. The results demonstrated an increase in the number of polymorphonuclear, goblet and mast cells, a decrease in claudin-1 expression and an elevation in E-cadherin expression during acute stress. Increased E-cadherin expression was also detected during chronic stress. Moreover, it was found that acute stress caused a shift towards a predominantly anti-inflammatory immune response (T helper 2 cells), as shown by the increase in the percentage of CD4 + /IL-6 + and CD4 + /IL4 + lymphocytes in the lamina propria and the increase in serum SP. In conclusion, this response promoted colonic protection during acute stress.

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Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma

Flores,

De Arruda,

Abrantes

et al. 2024

Braz. oral res.

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There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm 2 ), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm 2 ). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia ( p <0.001), AC with high-grade epithelial dysplasia ( p =0.005), and LLSCC ( p <0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate ( p =0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm 2 ). The link between mast cell density, factor XIIIa+ dendrocytes, and inflammatory infiltrate indicates a potential crosstalk in lip carcinogenesis.

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Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia

Cited by 4 publications

References 33 publications

Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study

Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study

CD4⁺/IL‑4⁺lymphocytes of the lamina propria and substance P promote colonic protection during acute stress

Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma

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Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia

Cited by 4 publications

References 33 publications

Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study

Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study

CD4+/IL‑4+lymphocytes of the lamina propria and substance P promote colonic protection during acute stress

Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma

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CD4⁺/IL‑4⁺lymphocytes of the lamina propria and substance P promote colonic protection during acute stress