Histopathological lesions in encephalon and heart of mice infected with Toxoplasma gondii increase after Lycopodium clavatum 200dH treatment

Pereira, Andréia Vieira; Góis, Marcelo Biondaro; Lera, Katiucha Rebeca Jennifer Lopes; Falkowski-Temporini, Gislane Janaina; Massini, Paula Fernanda; Drozino, Ricardo Nascimento; Aleixo, Denise Lessa; Miranda, Milena Menegazzo; Watanabe, Paulo da Silva; Conchon‐Costa, Ivete; Costa, Idessânia Nazareth; Filho, Mário dos Anjos Neto; Araújo, Silvana Márques de; Pavanelli, Wander Rogério

doi:10.1016/j.prp.2016.11.003

Cited by 14 publications

(7 citation statements)

References 40 publications

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“…En ratones con infección crónica se encontraron quistes tisulares, detectables a partir de 10 dpi, y la presencia de abundantes células inflamatorias en la luz de vasos sanguíneos (Dubey et al, 1998;Weiss & Kim, 2014). En estudios experimentales realizados en ratones Swiss infectados con la cepa ME49 se observaron infiltrados mononucleares perivasculares focales y multifocales y la aparición de quistes 15 dpi (Pereira et al, 2017). La misma cepa en ratones NIH generó infiltración mononuclear perivascular, nódulos gliales y numerosos quistes (Fuentes-Castro et al, 2017).…”

Section: Antecedentes De Ensayos En Modelo Murinounclassified

“…Las lesiones se hacen visibles a partir de los 7 a 9 dpi y se intensifican entre los 21 y 30 dpi (Pereira et al, 2017;Silva et al, 2010). En cuanto a las lesiones generadas por genotipos atípicos se observó leve meningoencefalitis en ratones BALB/c con infección crónica con la cepa de referencia no virulenta BrIII .…”

Section: Antecedentes De Ensayos En Modelo Murinounclassified

“…El análisis histopatológico se realizó mediante procedimiento de rutina con la tinción con hematoxilina y eosina (H/E). Se evaluó la aparición y severidad de las lesiones histopatológicas según el siguiente esquema de puntuación (Pereira et al, 2017;Venturini et al, 1996):…”

Section: Análisis Histopatológicounclassified

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Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina

Pardini

Bernstein

Carral

et al. 2019

Parasitology International

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Section: Antecedentes De Ensayos En Modelo Murinounclassified

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Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina

Pardini

Bernstein

Carral

et al. 2019

Parasitology International

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“…These functions may be associated with the diverse composition of secondary metabolites found in their spores [ 31 ], such as serratan triterpenoids [ 32 ]. Besides the impact on CD, the use of LC has also been evaluated in other conditions, such as in experimental Toxoplasma gondii infection [ 33 , 34 ], in vitro cytotoxic effect on colon cancer cells [ 35 , 36 ], and in a pilot study in humans with irritable bowel syndrome [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review

Neto

Guerra

Rodrigues

et al. 2022

Oxidative Medicine and Cellular Longevity

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Chagas disease is an anthropozoonosis caused by the protozoan Trypanosoma cruzi and is characterized as a neglected disease. It is currently endemic in 21 countries on the Latin American continent, including Bolivia, Argentina, and Paraguay. Unfortunately, there are no optimally effective treatments that can reduce the damage caused in the digestive form of the disease, such as the neuronal destruction of the myenteric plexus of both the esophagus and the colon. Therefore, the objective of this systematic review was to report the possible pharmacological neuroprotective agents that were tested in murine models of the digestive form of Chagas disease. Inclusion criteria are in vivo experimental studies that used different murine models for digestive forms of Chagas disease related to pharmacological interventions with neuroprotective potential, without year and language restriction. On the other hand, the exclusion criteria were studies that did not approach murine models with the digestive form of the disease or did not use neuroprotective treatments, among others. The search in the PubMed, Web of Science, Embase, and LILACS databases was performed on September 4, 2021. In addition, a manual search was performed using the references of the included articles. The risk of bias assessment of the studies was performed based on the SYRCLE tool guidelines, and the data from the selected articles are presented in this review as a narrative description and in tables. Eight articles were included, 4 of which addressed treatment with acetylsalicylic acid, 3 with cyclophosphamide, and 1 with Lycopodium clavatum 13c. In view of the results of the studies, most of them show neuroprotective activity of the treatments, with the potential to reduce the number of damaged neurons, as well as positive changes in the structure of these cells. However, more studies are needed to understand the mechanisms triggered by each drug, as well as their safety and immunogenicity. Systematic review registration is as follows: PROSPERO database (CRD42022289746).

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“…Until now, non-clonal genotypes have shown different virulence in mouse model, leading to difficulties on predict virulence based only on genotypes (Dubey, 2010;Dubremetz and Lebrun, 2012;Weiss and Kim, 2014). The morbidity rates, different degrees of histopathological lesions, the presence of T. gondii DNA and tissue cysts are associated with virulence in mouse models (Costa et al, 2018;Pereira et al, 2017;Pinheiro et al, 2015). Immune response in experimentally infected mice is characterized by the production of IFN-γ (gamma interferon), which induces the development of Th1 profile and macrophages activation helping to control the parasite proliferation, however paradoxically, its overproduction has been associated with acute virulence (Chen et al, 2016;Mordue et al,, 2001;Rodgers et al, 2005;Wang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biological behavior of Toxoplasma gondii atypical isolates # 14 and # 163

Bernstein

Pardini

Campero

et al. 2020

Experimental Parasitology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Histopathological lesions in encephalon and heart of mice infected with Toxoplasma gondii increase after Lycopodium clavatum 200dH treatment

Cited by 14 publications

References 40 publications

Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina

Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina

Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review

Evaluation of biological behavior of Toxoplasma gondii atypical isolates # 14 and # 163

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