Histopathological spectrum of salivary gland neoplasms in a tertiary care center

Abstract

Introduction: Salivary gland tumors are common neoplasms encountered in the head and neck region. Salivary gland neoplasms have varied histopathological findings with some of the tumors showing morphologic overlap. Majority of these neoplasms are benign in nature. They occur in both major and minor salivary glands. Benign tumors are more common in major salivary glands and malignant tumors generally occur in minor salivary glands. 80% of major salivary gland tumors occur in the parotid gland. Most of the minor salivary gland tumors are located in the palate. Proper diagnosis of malignant tumors with accurate staging is very important in the treatment and management of the patient. Aims and Objectives: This study was carried out to study the histopathological spectrum of salivary gland neoplasms in a tertiary care center. Materials and methods: The present study was conducted in the Pathology department of M.S Ramaiah Hospital on the surgically resected salivary gland tumor specimens received for routine histopathological evaluation, from January 2010 to December 2014. A total of 66 cases of salivary gland neoplasms were included in the study. Results: Out of total 66 cases studied, 38 cases (57%) were benign and 28 cases (43%) were malignant. Most common age group for salivary gland tumor was between 40-60 years. Among the tumors, female preponderance was seen in all except Warthin tumor. Pleomorphic adenoma was the most common benign tumor and mucoepidermoid carcinoma was the common malignant tumor. Parotid gland was the commonest site for various tumors, notable exception being adenoid cystic carcinoma, which showed predilection for the minor salivary glands. Pleomorphic adenoma was the most common salivary gland tumor representing 76.3% of benign and 43.9% of total salivary gland neoplasms Conclusion: Due to the varied histopathological findings with some morphologic overlap in salivary gland neoplasms histopathological examination is the mainstay for diagnosis and clinical management. Pleomorphic adenoma is the most common neoplasm of salivary glands. Benign tumors are more common in major salivary glands and malignant tumors are more common in minor salivary glands.

Histopathological study of neoplastic and non-neoplastic lesions of salivary gland: a study at a tertiary care center

“…22,25 Peak age range of Warthin tumor was 41-50 year and male preponderance(M:F ratio 3:1) which is similar to study Soni et al (peak age 41-60 years and M:F ratio of 1.5:1) and Ankur et al (peak age 41-50 years and M:F ratio of 4:0). 22,25 Parotid gland most commonly affected which is consistent with study Kumar et al 26 Heterotopic salivary tissue refers to the existence of salivary tissue at sites other than the 3 major salivary glands and the minor salivary glands. 12,18 In our study parotid gland was most common site for mucoepidermoid carcinoma followed by submandibular gland and minor salivary gland which correlates with the study of Renehan et al and Nagarkar et al 6,27 In this present study acinic cell carcinoma accounts for 15.38% of malignant tumor which is consistent with the study Vahahula et al, Mohd Ayub et al and Rewsuwan et al 9,10,23 Age group was 50-70 year which is consistent with the study Rewsuwan et al 10 Both cases occurred in female patient which is consistent with Vargas et al, Renehan et al and Mohd Ayub et al study.…”

“…Both were in palate. So, adenoid cystic carcinoma is most common in minor salivary gland which is similar to study Kumar et al, Rewsuwan et al and Hussain et al 10,26,28 Limitations of this study included a limited number of available cases of each tumor type and missing of some tumor types due to its relatively infrequent occurrence.…”

Histopathological spectrum of salivary gland lesions - in a tertiary care centre

“…Parotid gland is the commonest site for various tumors. 6 Among the various salivary gland lesions, female preponderance was seen in all the categories.…”

Clinicopathological study and management of salivary gland neoplasms in a tertiary care hospital

“…This result was comparable to the study conducted by Nezar et al from Syria and Kumar et al from Kerala and Karnataka. 8 The incidence of salivary gland neoplasms is more in the female population and the female to male ratio overall is 2:1. It is consistent with the studies of Nezar et al (2020) from Syria; Galdirs et al 6 In our study, 45 patients (86.53%) presented with only swelling of the involved gland, and in 7 patients (13.46%), the swelling was associated with pain which is similar to the results of the study conducted by Angelica et al from Brazil, Jimsha et al 7,9 The duration of the presenting symptoms ranged from 3 months to 4 years.…”