Background: Pipelle biopsy is ideal for obtaining endometrial sample in outpatient department. It samples only 4% of the endometrial surface and has sensitivity up to 97%. A positive biopsy can avoid inconvenience to a patient, but a nonspecific finding should be interpreted with caution. Thus, the objectives of this study were to analyze the efficacy of pipelle biopsy by adequacy of the sample obtained and also to establish the reliability by comparing the histopathology report obtained by pipelle biopsy with that of the hysterectomy specimen. Materials and Methods: A prospective study conducted at a tertiary care hospital on 104 women with abnormal uterine bleeding (AUB). They were scheduled for pipelle endometrial sampling before hysterectomy. The sensitivity, specificity, negative and positive predictive values, and accuracy of pipelle biopsy in diagnosing various endometrial pathologies were analyzed. The validity of pipelle biopsy was studied for endometrial hyperplasia and carcinoma and their statistical significance was tested. Results: The overall concordance rate was 63.8%. The sensitivity, specificity, positive and negative predictive values, and accuracy of pipelle biopsy for endometrial hyperplasia was 64.2%, 88.8%, 94.1%, 85.5%, and 47.3% and for endometrial carcinoma was 75%, 100%, 100%, 97.9%, and 98%, respectively. The P value for endometrial hyperplasia and carcinoma was 0.001 (statistically significant). Conclusion: Pipelle biopsy is valuable in diagnosing endometrial pathology of AUB cases. It has very high sensitivity and specificity for endometrial malignancies. A hysteroscopic dilatation and curettage is required for definitive diagnosis in cases of polyps and focal endometrial lesions.

Introduction: Salivary gland tumors are common neoplasms encountered in the head and neck region. Salivary gland neoplasms have varied histopathological findings with some of the tumors showing morphologic overlap. Majority of these neoplasms are benign in nature. They occur in both major and minor salivary glands. Benign tumors are more common in major salivary glands and malignant tumors generally occur in minor salivary glands. 80% of major salivary gland tumors occur in the parotid gland. Most of the minor salivary gland tumors are located in the palate. Proper diagnosis of malignant tumors with accurate staging is very important in the treatment and management of the patient. Aims and Objectives: This study was carried out to study the histopathological spectrum of salivary gland neoplasms in a tertiary care center. Materials and methods: The present study was conducted in the Pathology department of M.S Ramaiah Hospital on the surgically resected salivary gland tumor specimens received for routine histopathological evaluation, from January 2010 to December 2014. A total of 66 cases of salivary gland neoplasms were included in the study. Results: Out of total 66 cases studied, 38 cases (57%) were benign and 28 cases (43%) were malignant. Most common age group for salivary gland tumor was between 40-60 years. Among the tumors, female preponderance was seen in all except Warthin tumor. Pleomorphic adenoma was the most common benign tumor and mucoepidermoid carcinoma was the common malignant tumor. Parotid gland was the commonest site for various tumors, notable exception being adenoid cystic carcinoma, which showed predilection for the minor salivary glands. Pleomorphic adenoma was the most common salivary gland tumor representing 76.3% of benign and 43.9% of total salivary gland neoplasms Conclusion: Due to the varied histopathological findings with some morphologic overlap in salivary gland neoplasms histopathological examination is the mainstay for diagnosis and clinical management. Pleomorphic adenoma is the most common neoplasm of salivary glands. Benign tumors are more common in major salivary glands and malignant tumors are more common in minor salivary glands.

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