Study of the efficacy of pipelle biopsy technique to diagnose endometrial diseases in abnormal uterine bleeding

Abstract

Background: Pipelle biopsy is ideal for obtaining endometrial sample in outpatient department. It samples only 4% of the endometrial surface and has sensitivity up to 97%. A positive biopsy can avoid inconvenience to a patient, but a nonspecific finding should be interpreted with caution. Thus, the objectives of this study were to analyze the efficacy of pipelle biopsy by adequacy of the sample obtained and also to establish the reliability by comparing the histopathology report obtained by pipelle biopsy with that of the hysterectomy specimen. Materials and Methods: A prospective study conducted at a tertiary care hospital on 104 women with abnormal uterine bleeding (AUB). They were scheduled for pipelle endometrial sampling before hysterectomy. The sensitivity, specificity, negative and positive predictive values, and accuracy of pipelle biopsy in diagnosing various endometrial pathologies were analyzed. The validity of pipelle biopsy was studied for endometrial hyperplasia and carcinoma and their statistical significance was tested. Results: The overall concordance rate was 63.8%. The sensitivity, specificity, positive and negative predictive values, and accuracy of pipelle biopsy for endometrial hyperplasia was 64.2%, 88.8%, 94.1%, 85.5%, and 47.3% and for endometrial carcinoma was 75%, 100%, 100%, 97.9%, and 98%, respectively. The P value for endometrial hyperplasia and carcinoma was 0.001 (statistically significant). Conclusion: Pipelle biopsy is valuable in diagnosing endometrial pathology of AUB cases. It has very high sensitivity and specificity for endometrial malignancies. A hysteroscopic dilatation and curettage is required for definitive diagnosis in cases of polyps and focal endometrial lesions.

Assessing the Efficacy of Pipelle Sampling as Outpatient Diagnostic Test in a Tertiary Care Hospital-Rawalpindi, 2020

“…It is a thin, plastic suction tube about 3mm in diameter with graduated markings designed on it. 15 The most common presenting complaint in our study was heavy menstrual bleeding (38%) followed by post-menopausal bleeding (27%) which is in comparison to a study performed by Mathew et al 16 and Samal et al 17 , where heavy menstrual bleeding was the leading complaint in the per-imenopausal age group. This is also supported by a similar study done by Muzaffar et al 18 The incidence of the non-neoplastic lesion in our study was 91% and 4% were neoplastic lesions.…”

Modern Methods of Early Detection of Endometrial Cancer on the Example of “Pipelle” Urogenital Probe

“…This method is very popular because it is convenient and simple, painless, and less invasive. It allows you to take a sample of 4-10% of the endometrial surface and obtain data with a sensitivity of up to 97% [19]. "Pipelle" Sampling with a urogenetic probe does not require special training.…”

Clinical Evaluation of Li Brush Endometrial Samplers for Diagnosing Endometrial Lesions in Women With Intrauterine Devices

“…Screening endometrial lesions has been a research hotspot, especially for women with risk factors for endometrial cancer (26). Recently, research studies have focused on more minimally invasive screening devices and detecting methods (13,27). Nevertheless, no satisfactory screening method existed for women with IUDs.…”