Oral lesions contribute a major part in head neck diseasesIn India, head and neck cancers (HNCA) account for 30-40% cancers at all sites, out of which 9.4% being oral cancers. Oral cavity and oropharynx lesions have a major impact on physical, social and economic condition of the patient. To study the etiological and clinical profile of patients with lesions of oral cavity and oropharynx.Prospective study. Total 100 samples of oral cavity and oropharynx lesions were studied. Data collected with pre tested questionnaire. Data included sociodemographic data, history, risk factors associated with disease, clinical examination and pathological report of the patient. Appropriate statistical tests.Present study includes 100 cases of oral cavity and oropharyngeal lesions out of which 19% were inflammatory lesions, 10% tumour like lesions, 4% benign lesions, 4% premalignant lesions and 63% malignant lesions. Male to female ratio of 1.7:1. Among malignant lesions in our study, 60.3% had history of tobacco consumption, 17.5% consumed both alcohol and tobacco, 9.5% were alcoholics and 12.7% patients did not have any habits.