Histopathological study of radicular cysts diagnosed in a Brazilian population

Santos, Luciano Cincurá Silva; Bôas, Deise Souza Vilas; Oliveira, Gabriel Queiroz Vasconcelos; Ramos, Eduardo Antônio Gonçalves; Gurgel, Clarissa Araújo Silva; Santos, Jean Nunes dos

doi:10.1590/s0103-64402011000600002

Cited by 23 publications

(22 citation statements)

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“…The presence of plasma cells in cysts suggests a local humoral immune reaction, and indicates that the majority of the lesions were in a developing stage. 6 Another histopathological feature evaluated was the presence of cholesterol crystals, which were observed in 13.6% of periapical cysts, a rate similar to that found by Santos et al 16 The major source of cholesterol may be from locally dying inflammatory cells, and a result of the disintegrating membranes of these cells in long-standing lesions. 17 Accumulation of cholesterol crystals can prevent healing in apical periodontitis lesions, 17 but this accumulation does not seem to be associated with the maintenance of periapical cysts inasmuch as the frequency of its occurrence is low in these lesions.…”

Section: Resultssupporting

confidence: 55%

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

et al. 2013

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The aim of this study was to evaluate the prevalence of periapical cysts, identify their clinical and microscopic features and correlate their microscopic features with the inflammatory infiltrate present in the lesion site. A total of 214 cases were collected over a 10-year period. Clinical data, including gender, age, race, symptoms and location of the lesion, were recorded. Two independent examiners with no prior knowledge of the patients' clinical data conducted the microscopic evaluations. Statistical analyses were performed using Fisher's or chi-square tests at a 5% level of significance. The results showed that periapical cysts were more prevalent in white women, with a mean age of 35 years, and in the anterosuperior region. The majority of the lesions were lined by atrophic cystic epithelium, which was associated with moderate inflammatory infiltrate in the cystic capsule (p < 0.01), with a diffuse localization pattern (p = 0.03) and absence of neutrophils (p = 0.01). Our findings suggest that periapical cysts lined by atrophic epithelium are related to the presence of moderate mononuclear inflammatory infiltrate.

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Section: Resultssupporting

confidence: 55%

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

et al. 2013

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“…This study showed that the average size of radicular cysts with Actinomyces colonization was 1.78 cm, which is similar to the value reported by a previous study (24) in which the average size of these cysts was nearly 2.0 cm. When this result was compared with those previously described by Kukiane et al (23), although that study used a method different from the one applied in the present study, the presence of Actinomyces did not appear to increase the size of the radicular cyst lesions.…”

Section: Discussionsupporting

confidence: 91%

“…Histopathologically, all cases fulfilled the criteria for a radicular cyst (24), but all cases were associated with an Actinomyces infection. These colonies were present in the lumen or adjacent to the cyst, had different sizes, were isolated or sometimes overlapping, and were characterized by filamentous structures radiating from the center that were positive on PAS and Grocott staining and surrounded by an inflammatory infiltrate.…”

Section: Discussionmentioning

confidence: 94%

Actinomycosis is not Frequent in the Periapex But is a Persistent Lesion

Esteves

Henriques

Silva³

et al. 2017

Braz. Dent. J.

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Periapical actinomycosis caused by a gram-positive anaerobic pathogen characterizes a typical extra-radicular infection. This study determined the frequency and correlated the content of bacteria colonies with the of periapical actinomycosis size. The study comprised a total of 218 periapical lesions (PL) (cysts, granulomas or abscess). The specimens embedded in paraffin were sliced into 4-µm sections and stained with hematoxylin-eosin, Gram, Periodic Acid-Schiff (PAS) and Grocott's stain. The presence of bacterial colonies composed of filamentous structures labeled with the histochemical stains were described as Actinomyces, and for each case, the bacterial colonies were counted and measured. The correlation between the number and size of bacterial colonies and the size of PL was tested using Pearson's adjusted correlation coefficient. From 218 PL, bacterial colonies were identified in 64 biopsies. Seven cases (0.3%) fulfill the criteria for diagnosis of periapical actinomycosis. All of cases were therapy-resistant and did not showed periapical repair after 12 months of follow-up. Periapical surgery or dental extraction was performed. The correlation test indicated no correlation between the number of bacterial colonies and the lesion size (p=0.752, r=-0.148). However, a larger bacterial colony size generally resulted in a larger periapical lesion (P=0.000, r=0.657). The frequency of periapical actinomycosis was low, and this lesion should be included in the differential diagnosis of PL. The size of the Actinomyces colonies seemed to contribute to increase the size of the periapical lesion.

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“…Radicular cyst accounted for 12.6% of all the lesions in the present study, which was much higher than the data of Santos et al . (4.9%), reported in a Brazilian population of all ages. Additionally, radicular cyst was the most common lesion in the odontogenic cyst group (80%) in this study and was predominantly greater than the other lesions within this group; this result was similar to the data of other studies.…”

Section: Discussionmentioning

confidence: 83%