Histopathological study of the mammary gland in Trypanosoma cruzi-infected mice

Ribeiro, R D; Lopes, R. A.; Garcia, T A R; Campos, Ana

doi:10.1007/bf00539580

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Previous classifications by Brener and Chiari (1963) referring only to blood pleomorphism do not find these characteristics. However, research by Ribeiro et al (1988) corroborates the predominance of stout forms in the Bolivia strain in infections in Swiss mice.…”

Section: Discussionmentioning

confidence: 82%

Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies

Pénin

Gamallo

Diego³

1996

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 82%

Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies

Pénin

Gamallo

Diego³

1996

Mem. Inst. Oswaldo Cruz

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“…Therefore, the capacity of T. cruzi to invade the mammary gland of infected females has been undertaken. These histological investigations on mice demonstrate the presence of T. cruzi amastigotes in the mammary gland alveoli, excretory ducts, the connective tissue envelope of the ducts, interand intralobular connective tissue, histiocytes, adipose tissue, the sebaceous glands of the nipple, striated muscle fibers beneath the nipple, and inside the duct lumen [337]. Such proximity of T. cruzi parasites with colostrum or milk argues for the inactivation of T. cruzi by pasteurization or microwave treatment [338,339].…”

Section: Milkmentioning

confidence: 98%

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

Sereno

Akhoundi

Sayehmri

et al. 2020

IJMS

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Unicellular eukaryotes of the Trypanosomatidae family include human and animal pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the diseases they cause requires the sampling of body fluids (e.g., blood, lymph, peritoneal fluid, cerebrospinal fluid) or organ biopsies (e.g., bone marrow, spleen), which are mostly obtained through invasive methods. Body fluids or appendages can be alternatives to these invasive biopsies but appropriateness remains poorly studied. To further address this question, we perform a systematic review on clues evidencing the presence of parasites, genetic material, antibodies, and antigens in body secretions, appendages, or the organs or proximal tissues that produce these materials. Paper selection was based on searches in PubMed, Web of Science, WorldWideScience, SciELO, Embase, and Google. The information of each selected article (n = 333) was classified into different sections and data were extracted from 77 papers. The presence of Trypanosomatidae parasites has been tracked in most of organs or proximal tissues that produce body secretions or appendages, in naturally or experimentally infected hosts. The meta-analysis highlights the paucity of studies on human African trypanosomiasis and an absence on animal trypanosomiasis. Among the collected data high heterogeneity in terms of the I 2 statistic (100%) is recorded. A high positivity is recorded for antibody and genetic material detection in urine of patients and dogs suffering leishmaniasis, and of antigens for leishmaniasis and Chagas disease. Data on conjunctival swabs can be analyzed with molecular methods solely for dogs suffering canine visceral leishmaniasis. Saliva and hair/bristles showed a pretty good positivity that support their potential to be used for leishmaniasis diagnosis. In conclusion, our study pinpoints significant gaps that need to be filled in order to properly address the interest of body secretion and hair or bristles for the diagnosis of infections caused by Leishmania and by other Trypanosomatidae parasites.

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“…Therefore, the capacity of T. cruzi to invade the mammary gland of infected females has been undertaken. These histological investigations on mice demonstrate the presence of T. cruzi amastigotes in the mammary gland alveoli, excretory ducts, the connective tissue envelope of the ducts, inter-and intralobular connective tissue, histiocytes, adipose tissue, the sebaceous glands of the nipple, striated muscle fibers beneath the nipple, and inside the duct lumen [331]. Such proximity of T. cruzi parasites with colostrum or milk argues for the inactivation of T. cruzi by pasteurization or microwave treatment [332,333].…”

Section: Milkmentioning

confidence: 98%

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

Sereno¹,

Akhoundi²,

Sayehmri³

et al. 2020

Preprint

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Unicellular eukaryotes of the Trypanosomatidae family include human and animal pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the diseases they caused requires the sampling of body fluids (blood, lymph, peritoneal fluid, cerebrospinal fluid, etc.) or organ biopsies (bone marrow, spleen, etc.), which are mostly obtained through invasive methods. Body fluids or appendages can be alternatives to these invasive biopsies but appropriateness remains poorly studied. To further address this question, we perform a systematic review on clues evidencing the presence of parasites, genetic material, antibodies, and antigens in body secretions, appendages, or the organs or proximal tissues that produce these materials. Paper selection was based on searches in PubMed, Web of Science, WorldWideScience, SciELO, Embase, Google. The information of each selected article (n=333) was classified into different sections and data were extracted from 77 papers. The presence of Trypanosomatidae parasites has been tracked in most of organs or proximal tissues that produce body secretions or appendages, in naturally or experimentally infected hosts. The meta-analysis highlights the paucity of studies on Human African Trypanosomiasis and a the absence on animal Trypanosomiasis. Among the collected data high heterogeneity in terms of the I2 statistic (100%) is recorded. A high positivity is recorded for antibody and genetic material detection in urine of patients and dogs suffering leishmaniasis, and of antigen for leishmaniasis and Chagas disease. Data on conjunctival swab can be analyzed with molecular methods solely for dogs suffering canine visceral leishmaniasis. Saliva and hair/bristle showed a pretty good positivity that support their potential to be used for leishmaniasis diagnosis. In conclusion, our study pinpoints significant gaps that need to be filled in order to properly address the interest of body secretion and hair or bristle for the diagnosis of infections caused by Leishmania and by other Trypanosomatidae parasites.

show abstract

Histopathological study of the mammary gland in Trypanosoma cruzi-infected mice

Cited by 6 publications

References 2 publications

Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies

Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

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