Histopathology and Prognostic Indices of Carcinoma Breast with Special Reference to p53 Marker

Radha, R.

doi:10.7860/jcdr/2014/9114.4609

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…The p53 protein is a DNA‐binding protein localized to the nucleus, which functions primarily by controlling the transcription of several other genes responsible for cell growth and also mediates cell cycle arrest and apoptosis (27) . Previous data found that p53 overexpressing tumors demonstrate aggressive characteristics, including larger size, higher grade, and necrosis in comparison with p53 negative cases (28) . On the other hand,

v_{e}

is one of the main pharmacokinetic parameters suggesting EES volume fraction.…”

Section: Discussionmentioning

confidence: 91%

Characteristics of quantitative perfusion parameters on dynamic contrast‐enhanced MRI in mammographically occult breast cancer

Ryu

Rhee

Song

et al. 2016

J Applied Clin Med Phys

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The purpose of this study was to compare the characteristics of quantitative perfusion parameters obtained from dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans,kep,ve,vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE‐MRI data were acquired. Various prognostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki‐67, p53, E‐cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group. Fisher's exact test was used to compare any differences of the various prognostic factors between the two groups. The Mann‐Whitney U test was applied to compare the quantitative parameters between these two groups. Finally, Spearman's correlation was used to investigate the relationships between perfusion indices and four factors — age, tumor size, Ki‐67, and p53 — for each group. Although age, tumor size, and the prognostic factors were not statistically different between the two groups, the mean values of the quantitative parameters, except wi in the MV group, were higher than those in the MO group without statistical significance false(p=0.219false). The kep value was significantly different between the two groups false(p=0.048false), but the other parameters were not. In the MO group, vp with size, ve with p53, and Ktrans and vp with Ki‐67 had significant correlations (p<0.05). However, in the MV group, only kep showed significant correlation with age. The kep value was only the perfusion parameter of statistical significance between MO and MV breast cancers.PACS number(s): 87.19.U‐, 87.61.‐c

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v_{e}

is one of the main pharmacokinetic parameters suggesting EES volume fraction.…”

Section: Discussionmentioning

confidence: 91%

Characteristics of quantitative perfusion parameters on dynamic contrast‐enhanced MRI in mammographically occult breast cancer

Ryu

Rhee

Song

et al. 2016

J Applied Clin Med Phys

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show abstract

“…However, Radha et al reported an equivocal P53 status in both the positive and negative cases of lymph node metastases in immunohistochemistry results. 21 In this study, the odds ratio of P53 positivity were 0.97 times (95% CI, 0.59–1.57, P = 0.892) in people with positive lymph node status. In other words, no correlations were possible between P53 and axillary lymph node metastases.…”

Section: Discussionmentioning

confidence: 51%

Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer

Chung

Lee²,

Kim³

et al. 2016

Medicine

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The aim of this study was to evaluate the association between pretreatment molecular and clinical factors and axillary lymph node metastases in early breast cancer. A total of 367 consecutive breast cancer patients with cT1–2NxM0 who underwent breast conserving surgery and axillary lymph node dissection followed by whole breast irradiation were enrolled. We evaluated the pathologic tumor and node status, tumor differentiation, calcification, and lymphovascular invasion, the status of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor 1 (EGFR1), and human epidermal growth factor receptor 2 (HER2), the expression of E-cadherin, P53, and Ki-67 index. Totally, 108 (29.4%) of the 367 patients had positive axillary lymph nodes. An increased tumor size (P = 0.024), the presence of lymphovascular invasion (P < 0.001), and Ki-67 index of >20% (P = 0.038) were significantly associated with axillary lymph node metastases on the multivariate analysis. In our study, 86.2% of the patients with all the unfavorable factors had an involvement of axillary nodal metastases, and only 12.2% of the patients with all the favorable predictors had positive axillary nodes. The predictive power was significant on the receiver operating curve (P < 0.001). We found that several factors, such as tumor size, lymphovascular invasion, and the Ki-67 index, are independent factors that predict positive ALNM on multivariate analysis for the patients with cT1–2 breast cancer. Clinicians simply could predict the probability of ALNM after verifying the molecular and clinical factors in early breast cancer.

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“…Percentage of positive cells varied from <10% to >50% with weak, intermediate and strong intensity. In many other studies by Arora et al, [1] Patnayak et al, [6] Sekar et al, [13] Radha et al, [14] Neharika et al [10] p53 positivity was observed in 61.5%, 69.2%, 71.6%, 22%, 47.4% cases respectively. Variability in the p53 expression may be attributed to the diverse range of procedures and reagents used by different investigators.…”

Section: P53 Scoringmentioning

confidence: 82%

To compare the expression of p53 with hormonal receptor status in breast carcinoma: An immunohistochemical study

Sandeep¹,

Kaur²,

Piplani³

et al. 2023

Int. J. Clin. Diagn. Pathol.

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Background: Breast carcinoma is the most common malignancy in women in the world. This study evaluated the expression of ER, PR and p53 in breast carcinoma and its correlation with age, size, lymph node status and other parameters. Methods: 103 histologically proven Breast carcinoma cases were subjected to IHC for ER,PR and p53. Result: Total cases of breast cancer were 103. All the cases were between 21-60 years with tumour size varying from 0.5->5cm. Maximum cases were of grade III. Metastatic carcinomatous deposits in lymph nodes were seen in 53 cases. Tumors were separated into 4 categories depending on ER/PR expression with ER-ve/PR-ve category having maximum number of cases. As the tumour grade increased lesser was the ER PR expression. P53 positivity was noted in 60 cases comprising of 58.3%. Significant correlation was noted while comparing p53 with lympho vascular invasion (p=0.042) but not with age, tumour size, tumour grade and lymph node status. Significant correlation was also noted while correlating p53 and ER/PR expression with tumour size (p = 0.036) but not with tumour grade, lympho vascular invasion and lymph node status. Conclusion:In the present study it was observed that ER PR status is inversely proportional to p53 expression. It is concluded that p53 has direct relationship with tumour grade, tumour size, lymphovascular invasion. Thus p53 helps to provide prognostic information and better treatment options

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Histopathology and Prognostic Indices of Carcinoma Breast with Special Reference to p53 Marker

Cited by 6 publications

References 13 publications

Characteristics of quantitative perfusion parameters on dynamic contrast‐enhanced MRI in mammographically occult breast cancer

Characteristics of quantitative perfusion parameters on dynamic contrast‐enhanced MRI in mammographically occult breast cancer

Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer

To compare the expression of p53 with hormonal receptor status in breast carcinoma: An immunohistochemical study

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