Histopathology Diagnosis of Filamentous Fungi

Challa, Sundaram; Radha, Sistla

doi:10.1007/s12281-021-00428-4

Cited by 7 publications

(8 citation statements)

References 89 publications

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“…Furthermore, cultures from the upper respiratory tracts often reflect colonization rather than invasive disease. Due to the ubiquitous nature of certain filamentous fungi, cultures are also subject to spurious contamination by conidia/spores in the environment [ 17 , 18 ]. Mold cultures also fail to yield information in real-time.…”

Section: Use Of Fungal Cultures For Diagnosismentioning

confidence: 99%

“…Currently, no one diagnostic platform meets all of these criteria. Many molecular based-platforms that are that are performed on direct specimens are not widely available in clinical microbiology laboratories, nor is any one of these currently sufficient to replace cultures as the gold-standard for the diagnosis of invasive mycoses [ 18 ].…”

Section: Use Of Fungal Cultures For Diagnosismentioning

confidence: 99%

“…Histopathology continues to be a rapid and cost-effective means of providing a presumptive diagnosis of invasive fungal infections, as the presence of fungi, as determined by histopathology or cytology within normally sterile tissue or fluids, is also a criterion for proven fungal infection in patients with risk factors for invasive infections [ 9 ]. In many instances, histopathology may be the only means of diagnosis when material is not submitted for culture or other laboratory tests, or when the results of such laboratory evaluations are still pending [ 18 ]. Histopathology also has the advantages of being standardized and relatively cost-effective, although invasive procedures are often required to obtain the needed tissue.…”

Section: Use Of Histopathology For Diagnosis Of Invasive Fungal Infec...mentioning

confidence: 99%

“…Histopathology also has the advantages of being standardized and relatively cost-effective, although invasive procedures are often required to obtain the needed tissue. Several factors that should be considered during histopathology work-up and which affect the differential diagnosis include the host immune status, the patient’s travel and social history, the geographic region when infection may have occurred, and antifungal exposure [ 18 , 23 ]. To identify and assess the morphology of fungus in tissue sections, special stains are better than the routine hematoxylin eosin (H&E) stain.…”

Section: Use Of Histopathology For Diagnosis Of Invasive Fungal Infec...mentioning

confidence: 99%

“…To help establish a diagnosis of invasive fungal disease, histopathology findings should take into account the fungal morphologies that are observed combined with the extent of tissue invasion and the immune response seen within the specimen [ 17 , 18 , 23 ]. Morphologically, fungi may appear as yeast forms, hyphal forms (molds), or as dimorphic forms.…”

Section: Use Of Histopathology For Diagnosis Of Invasive Fungal Infec...mentioning

confidence: 99%

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Diagnosis from Tissue: Histology and Identification

Sabino

Wiederhold

2022

JoF

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The diagnosis and initiation of appropriate treatment against invasive fungal infections depend upon accurate identification of pathogens by pathologists and clinical microbiologists. Histopathology is often critical in providing diagnostic insight in patients with suspected fungal infections, and such findings are incorporated into the definitions of proven or probable disease caused by certain pathogens. Such examinations can offer provisional identifications of fungal organisms, which can help guide initial therapy while laboratory results are pending. Common etiologic agents of invasive mycoses may be recognized based on morphologic characteristics observed in tissue and biologic fluids, such as those obtained from bronchoalveolar lavage and bronchial washings. However, care should be taken in the interpretation of these findings, as there may be a false sense of the ability to correctly categorize fungal organisms to the genus or species level by morphologic features alone. Studies have demonstrated discordant results between histopathology and laboratory results due to overlapping morphologic features, morphologic mimics, and sampling errors. Thus, histopathology plays an integral role in providing a differential of potential fungal pathogens but must be combined with results from laboratory studies, including cultures, antigen tests, serology, and molecular assays, in order to improve accuracy in the identification of etiologic agents of fungal infections. Inaccurate identification of the infecting organism can lead to inappropriate antifungal therapy and possibly poor clinical outcomes.

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Section: Use Of Fungal Cultures For Diagnosismentioning

confidence: 99%

Section: Use Of Fungal Cultures For Diagnosismentioning

confidence: 99%

Section: Use Of Histopathology For Diagnosis Of Invasive Fungal Infec...mentioning

confidence: 99%

Section: Use Of Histopathology For Diagnosis Of Invasive Fungal Infec...mentioning

confidence: 99%

Section: Use Of Histopathology For Diagnosis Of Invasive Fungal Infec...mentioning

confidence: 99%

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Diagnosis from Tissue: Histology and Identification

Sabino

Wiederhold

2022

JoF

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Identical radiological and clinical pre‐diagnostic findings of a mucor fungus ball with uncommon histopathological appearance

Er,

Karaca,

Koç

et al. 2024

Oral Science International

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BackgroundThe present case is a valuable sample revealing a noninvasive mucor fungus ball (FB)'s etiological factors and radiologic characteristics.Case PresentationThe hemifacial pain complaint of the patient was started following the development of type II diabetes. A homogenous and partial radiopacity was radiologically monitored in the left maxillary sinus. An FB in the necrotic background, primarily originating from mucor, was histopathologically diagnosed. A 1‐year follow‐up was completed uneventfully.ConclusionDiabetes could trigger a symptomatic mucor FB development. Practitioners should be aware of a mucor FB existence if a partial homogenous radiopacification is seen in the maxillary sinuses.

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