Histopathology of columnar-lined esophagus in patients with gastroesophageal reflux disease

Lenglinger, Johannes; Ringhofer, Claudia; Eisler, Margit; Sedivy, Roland; Wrba, Fritz; Zacherl, Johannes; Cosentini, Enrico P.; Prager, Gerhard; Haefner, Michael; Riegler, Martin

doi:10.1007/s00508-007-0825-0

Cited by 18 publications

(47 citation statements)

References 37 publications

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“…Endoscopic equipment: Esophagogastroduodenoscopy was performed using an Olympus endoscope GIF6 connected to an Olympus video unit (CV-200, CLV-u20, TC-V1, EXERA CV-160; Olympus Inc. Austria) connected to a Sony monitor system (Sony Company Austria), as previously described [30,31]. Biopsies were obtained using Olympus biopsy forceps FB-24 KR-1 (Olympus Inc. Austria) [30,31].…”

Section: Methodsmentioning

confidence: 99%

“…We recently found that all of 114 persons with gastroesophageal reflux disease (GERD) had cardiac or oxyntocardiac mucosa at the endoscopic esophagogastric junction, i.e. the level of the rise of gastric folds [30]. In none of the patients, even in those with an endoscopically normal-appearing esophagogastric junction, did biopsies contain gastric oxyntic mucosa.…”

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confidence: 98%

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Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease

Ringhofer¹,

Lenglinger²,

Izay³

et al. 2008

Wien Klin Wochenschr

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Section: Methodsmentioning

confidence: 99%

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confidence: 98%

Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease

Ringhofer¹,

Lenglinger²,

Izay³

et al. 2008

Wien Klin Wochenschr

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“…Whenever neoplastic consequences of GERD are discussed, a recurrent exposition of the esophagus to refluxate will lead GERD potentially to progress into metaplasia and dysplasia [4]. However, the dissection of the distal esophagus during surgery might lead to an altered sensitivity within the esophagus, thus leading to esophagitis without heartburn when reflux recurs.…”

Section: Dear Sirsmentioning

confidence: 99%

On: Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility [Surg Endosc 22(1):21–30]

Wykypiel

Wetscher

2008

Surg Endosc

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Dear sirs,We read with great interest the recent publication entitled ''Laparoscopic fundoplication: Nissen versus Toupet twoyear outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility'' [1].We already published in 2005 an analysis of our patients operated within the so-called tailored approach on 209 patients with a median follow-up of 52 months [2]. We compared those patients without recurrence regarding their long-term symptoms and their functional results and came to the same conclusion as the authors of the above mentioned publication.The laparoscopic partial posterior (Toupet) fundoplication seems to be the better operative procedure for the treatment of gastroesophageal reflux disease (GERD).It has a lower rate of side effects, nota bene less dysphagia and, given the appropriate technique, it restores the antireflux barrier to the same extent as the Nissen fundoplication [2]. Moreover, in our studies [2, 3] we were even able to demonstrate an improvement of former impaired esophageal motility in the Toupet group, while this was not found in the Nissen group. In our study, there was a strong correlation between postoperative dysphagia and impaired postoperative lower esophageal sphincter (LES) relaxation (Spearman correlation; r s = -0.75 at a p value \0.05) and the same was true for bloating (r s = -0.71), inability to belch (r s = -0.82), inability to vomit (r s = -0.86), and epigastric pain (r s = -0.68). In other words, the Nissen fundoplication may lead to an impairment of the LES relaxation often to an extent like in achalasia, while this was not seen after a Toupet fundoplication; so we concluded that an impaired relaxation could be the main cause of this problem.

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“…Viral infections, inflammation, autoimmune processes and a genetic predisposition are discussed as possible causes. The condition begins with slight swallowing disturbances and progresses slowly over years; if untreated it often results in a dilated aperistaltic (sigmoid or mega-) esophagus at risk for aspiration, malignoma [1][2][3][4] or even perforation. The main symptoms are dysphagia for liquid and solid food, regurgitation of indigested food, and heartburn.…”

Section: Introductionmentioning

confidence: 99%

Roboterassistierte laparoskopische Cardiomyotomie

Wykypiel

Bodner

Augustin

et al. 2009

Wien Klin Wochenschr

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Histopathology of columnar-lined esophagus in patients with gastroesophageal reflux disease

Abstract: Columnar-lined esophagus cannot be excluded by endoscopy. In patients with gastroesophageal reflux disease, biopsy sampling of normal-appearing junction is recommended for histopathologic exclusion of intestinal metaplasia and low-grade dysplasia.

Cited by 18 publications

References 37 publications

Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease

Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease

On: Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility [Surg Endosc 22(1):21–30]

Roboterassistierte laparoskopische Cardiomyotomie

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