Histopathology of Cutaneous Leishmaniasis

Kurban, Amal K.

doi:10.1001/archderm.1966.01600220008002

Cited by 58 publications

(13 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Kurban et al . 45 and Mansour et al . 46 , suggested two histological patterns in biopsies of patients with CL: the first one corresponding to lesions with less than one year of duration associated with a diffuse infiltrate, and the second one corresponding to lesions of more than one year of duration with granulomatous infiltrate.…”

Section: Discussionmentioning

confidence: 94%

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

González

Diaz

Ferreira

et al. 2018

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama. We analyzed 49 skin biopsy samples from patients with clinical suspicion of CL, by molecular tests (PCR for subgenus Viannia and HSP-70) and by Hematoxylin-Eosin staining. Samples were characterized at the species level by PCR-HSP-70/RFLP. From the 49 samples studied, 46 (94%) were positive by PCR and were characterized as Leishmania (V.) panamensis. Of these, 48% were positive by Hematoxylin-Eosin staining with alterations being observed both, in the epidermis (85%) and in the dermis (100%) of skin biopsies. The inflammatory infiltrate was characterized according to histopathological patterns: lymphohistiocytic (50%), lymphoplasmacytic (61%) and granulomatous (46%) infiltration, being the combination of these patterns frequently found. The predominant histopathological characteristics observed in CL lesions caused by L. (V.) panamensis in Panama were: an intense inflammatory reaction in the dermis with a combination of lymphohistiocytic, lymphoplasmacytic and granulomatous presentation patterns and the presence of ulcers, acanthosis, exocytosis and spongiosis in the epidermis.

show abstract

Section: Discussionmentioning

confidence: 94%

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

González

Diaz

Ferreira

et al. 2018

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…A large number of plasma cells may be seen in late lesions of acute cutaneous leishmaniasis. Leishman bodies (amastigotes within macrophages) are identifiable in approximately half of the cases of acute cutaneous leishmaniasis in this late stage [8]. Necrosis of the dermal collagen is rare, and loss of elastic fibers and adnexal structures manifest clinically as atrophic scarring.…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

“…Both atrophy and epidermal acanthosis may be seen. At times, the acanthosis may approach pseudoepitheliomatous epidermal hyperplasia [8]. Follicular plugging and hydropic degeneration of the basal cell layer may also be found.…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

In vivo Confocal Microscopy Features of Cutaneous Leishmaniasis

et al. 2014

View full text Add to dashboard Cite

Background: Cutaneous leishmaniasis is widely distributed, Spain being a hypoendemic region. Noninvasive bedside detection of the histopathologic response to the intracellular organism that allows rapid diagnosis and prompt therapy could be the ideal tool to manage a commonly self-healing lesion. Confocal microscopy is a technique which allows in vivo examination of the skin at cellular resolution. Methods: We describe the in vivo confocal microscopic features of cutaneous leishmaniasis, finding a correlation with dermoscopy and histopathology. Conclusions and Relevance: This case illustrates the capability of confocal microscopy to characterize the cutaneous infection by Leishmania organisms and to perform a noninvasive diagnosis.

show abstract

“…Cutaneous leishmaniasis became overt in travellers from endemic regions.3ll 312 Peculiar histologic dermal changes aid in diagnosis when the microbes cannot be found. 313 Diarrhoeal disease and respiratory tract infections most often of viral origin and malaria are the chief causes of illness among foreign troops in Vietnam. Dengue, scrub typhus, leptospirosis also are prevalent and about 20% of fevers are of unknown origin.314 Thirty cases of melioidosis occurred.…”

Section: Miscellaneousmentioning

confidence: 99%

Infectious diseases. Annual review of significant publications

Reimann

1967

Postgraduate Medical Journal

View full text Add to dashboard Cite

Histopathology of Cutaneous Leishmaniasis

Cited by 58 publications

References 2 publications

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

In vivo Confocal Microscopy Features of Cutaneous Leishmaniasis

Infectious diseases. Annual review of significant publications

Contact Info

Product

Resources

About