Histopathology of Early Effects of Oral Cadmium in the Rat Kidney

Aughey, E.; Fell, G. S.; Scott, R.; Black, M.

doi:10.2307/3429802

Cited by 19 publications

(21 citation statements)

References 6 publications

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“…In agreement with a large number of studies who noted similar or more pronounced changes in the hepa tic and renal tissues under Cd effect [2,9,11,[20][21][22][23][24]. Our results indicated significant CdCl 2 toxic effects on the liver and kidney structures.…”

Section: Resultssupporting

confidence: 81%

“…Our results indicated significant CdCl 2 toxic effects on the liver and kidney structures. As mentioned previously [20] early pathological changes in rat kidney obtained after 6 weeks of administration of 50 mg Cd/l in drinking water. After 12 weeks, they revealed signs of tubular necrosis, interstitial fibrosis and glomerular epithelial cell hypertrophy in small areas of the kidney cortex.…”

Section: Resultsmentioning

confidence: 99%

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Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran¹,

Osman²

2011

J Cytol Histol

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran¹,

Osman²

2011

J Cytol Histol

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“…Exposure to toxins such as cadmium and lead, which cause tubular dysfunction and chronic interstitial nephritis in exposed humans and rodents (24,(28)(29)(30)(31)(32), is typically chronic and sustained. Such circumstances could provoke prolonged HSP70 expression, and allow autoreactive, HSP70-specific T cells to expand in number and mediate injury.…”

Section: Discussionmentioning

confidence: 99%

T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.

Weiss

Madaio

Tomaszewski

et al. 1994

The Journal of Experimental Medicine

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SummaryT cells reactive against immunodominant regions of inducible heat shock proteins (HSPs) have been identified in the chronic inflammatory lesions of several experimental autoimmune diseases. Since HSPs are known to be induced by a number of renal tubular epithelial cell toxins associated with chronic interstitial nephritis, we investigated the relevance of HSP expression and T cell reactivity to HSP70 in a model of progressive inflammatory interstitial nephritis. Chronic administration of cadmium chloride (CdClz) to SJL/J mice induces HSP70 expression in renal tubular cells 4-5 wk before the development of interstitial mononuclear cell infiltrates. CdC12 also induces HSP70 expression in cultured tubular epithelial cells from SJL/J mice. CD4 +, TCR-od~ + T cell lines specific for an immunodominant HSP peptide are cytotoxic to heat stressed or CdClz-treated renal tubular cells. Such HSP-reactive T cells mediate an inflammatory interstitial nephritis after adoptive transfer to CdClz-treated mice at a time when immunoreactive HSPT0 is detectable in the kidneys, but before the development of interstitial mononuclear cell infiltrates. T cells isolated from the nephritic kidneys of mice treated with CdC12 for 13 wk are also cytotoxic to heat shocked or cadmium-treated tubular cells. These kidney-derived T cells additionally induced interstitial nephritis after passive transfer, indicating their pathogenic significance. Our studies strongly support a role for HSP-reactive T ceils in CdC12-induced interstitial nephritis and suggest that the induction of HSPs in the kidney by a multitude of "nonimmune" events may initiate or facilitate inflammatory damage by HSP-reactive lymphocytes.

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“…It is known that chronic exposure to cadmium can induce severe nephropathy in humans [28] and animals [29,30] . This nephrotoxic causes reabsorptive and secretory dysfunction of the renal tubule.…”

Section: Introductionmentioning

confidence: 99%

Camel's Milk Protects Against Cadmium Chloride Induced Toxicity in White Albino Rats

Al‐Hashem¹,

Dallak²,

Bashir³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement:Cadmium is one of the most dangerous occupational and environmental toxins. It is found in drinking water, atmospheric air and even in food. Cadmium is reported to be very toxic to biological systems. Until now in treating intoxication with this metal, chelating Compounds have been used, burdened with numerous undesirable symptoms. For this reason, many researches are carried out in many countries to find natural-made compounds that help in the protection against cadmium induced toxicity with fewer or no side effects. This study was conducted to demonstrate the effect of daily oral Camel's milk administration against Cadmium chloride induced toxicity in white albino rats. Approach: White albino rats of both sexes (230-250 g) were housed in standard metal cages (6 rats/cage). The experimental rats (6 in each group) distributed into two experimental groups with a shared control group received only normal saline orally (Group 1). In experimental first group a daily dose (10 mg kg  1 body weight) of cadmium chloride was orally administrated to the rats for 21 days and named Cadmium chloride treated rats. In experimental second group, the same concentrations of cadmium chloride was dissolved in 2 mL of early morning fresh Camel's milk and the whole solution was administered into the experimental rats for 21 days and named Camel's milk cadmium chloride treated group. Water and food were provided ad libitum. Results: The data indicated that, in experimental Cadmium chloride treated rats, serum albumin, calcium and blood hemoglobin were decreased compared with control group received normal saline only. Moreover, Camel's milk administration with cadmium chloride showed a significant improvement of albumin, hemoglobin and calcium levels in the serum of the rats compared with cadmium chloride treated rats. Serum iron, sodium, chloride and urea levels were significantly increased in cadmium chloride treated rats compared with control group, while the addition of camel's milk to cadmium chloride decreased the high levels of these serum parameters in the treated rats. The enzyme activities of serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and serum Alkaline Phaospatase (ALP) were significantly increased by orally administration of cadmium chloride compared with control group, while adding Camel's milk to cadmium chloride decreased the high levels of these enzymes comparing with the cadmium chloride treated rats. Cadmium chloride administration resulted in a high concentration of lipid peroxidation markers; TBARS and Hydroperoxides in comparison to control group, adding camel's milk to the cadmium chloride restored the levels of these markers to their normal levels in comparing to Cadmium chloride treated rats. Also treatment with cadmium chloride alone caused a significant decrease in both the enzymatic and nonenzymatic markers of oxidative stress (superoxide dismutase and catalase) and reduced glutathione, respectively in the liver tissues of treated rats, while the admini...

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Histopathology of Early Effects of Oral Cadmium in the Rat Kidney

Cited by 19 publications

References 6 publications

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.

Camel's Milk Protects Against Cadmium Chloride Induced Toxicity in White Albino Rats

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