Histopathology of Failed Osteoarticular Shell Allografts

Kandel, Rita A.; Gross, Allan E.; Ganel, A; Mcdermott, A. G. P.; Länger, F; Pritzker, Kenneth P.H.

doi:10.1097/00003086-198507000-00012

Cited by 85 publications

(71 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The use of fresh osteochondral allografts is supported by experimental 3,4,[17][18][19] and clinical 5,8,9,20,21 evidence of the viability and function of cartilage after transplantation. A review of our first 100 cases showed that the best indication for this procedure was a post-traumatic unipolar defect consisting of bone and cartilage, 12 in patients not considered for osteotomy alone because of the size of the osseous defect (Figs 6 and 7).…”

Section: Discussionmentioning

confidence: 99%

“…5 The bony parts of these small grafts are replaced by host bone in two to three years by creeping substitution. 8,9 Union between the host and graft takes place at about six months and a significant portion of the graft has been replaced at one year although the graft may be subject to collapse for two to three years. 9,12 We therefore advise the use of a brace only for one year but suggest that impact activities are avoided for two to three years.…”

Section: Discussionmentioning

confidence: 99%

“…Since the first attempts at osteochondral transplantation by Lexer in 1908, 1,2 both animal and clinical studies in immunology and transplantation have shown that transplanted fresh cadaver cartilage is viable. [3][4][5][6][7][8][9] In these small fragments, allograft is replaced by host bone in a homogeneous fashion by creeping substitution. [10][11][12] Since 1972, we have used fresh osteochondral allografts for the reconstruction of joint defects due to injury.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Ghazavi¹,

Pritzker

Davis³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

Self Cite

198

125

View full text Add to dashboard Cite

We used fresh small-fragment osteochondral allografts to reconstruct post-traumatic osteochondral defects in 126 knees of 123 patients with a mean age of 35 years. At a mean follow-up of 7.5 years (2 to 20), 108 knees were rated as successful (85%) and 18 had failed (15%).The factors related to failure included age over 50 years (p = 0.008), bipolar defects (p < 0.05), malaligned knees with overstressing of the grafts, and workers' compensation cases (p < 0.04). Collapse of the graft by more than 3 mm and of the joint space of more than 50% were seen more frequently in radiographs of failed grafts.Our encouraging clinical results for fresh smallfragment osteochondral allografts show that they are indicated for unipolar post-traumatic osteochondral defects of the knee in young active patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Ghazavi¹,

Pritzker

Davis³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

Self Cite

198

125

View full text Add to dashboard Cite

show abstract

“…For this reason, the principal immunogenic tissue of the fresh transplant is the bone layer, which can lead to varying degrees of response depending on the amount of bone transplanted, but it does not require immunosuppression after the procedure (22) . The inflammatory response to the transplanted tissue generally decreases over time, and can continue for up to 18 to 24 months after the procedure (23) .…”

Section: Basic Sciencementioning

confidence: 99%

O uso do transplante osteocondral a fresco no tratamento das lesões osteocondrais do joelho

Tírico¹,

Demange²

2012

Rev. bras. ortop.

View full text Add to dashboard Cite

show abstract

“…The success of cartilage allografts may therefore be due to the relative isolation of the chondrocyte in this matrix (McGlynn and Sharpe 1981). Viable cartilage allograft has been identified after seven years (Kandel et al 1985) and biopsies of osteochondral allografts have shown live chondrocytes six years after transplantation (Czitrom, Keating and Gross 1990).…”

mentioning

confidence: 99%

Hiv Infection of Human Cartilage

Campbell

Oakeshott

1996

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

I nfection of human cartilage with HIV in vivo hasnot previously been reported. Specimens of articular cartilage taken at postmortem from ten patients who were HIV-positive were examined. Two had AIDS and eight were believed to have stage-2 disease.The standard polymerase chain reaction (PCR) protocol was modified to allow semiquantitative analysis of the samples. Oligonucleotide primers labelled with 32 P gamma-ATP were used to detect a segment of HIV DNA and a control DNA gene segment (HLA genome) to estimate the ratio of infected cells. The 32 P-labelled PCR products were separated on acrylamide gels and visualised directly by autoradiography and computer densitometry.Infection of human cartilage in vivo was demonstrated in nine of the ten samples in which the PCR analysis was positive. The other did not react sufficiently to produce detectable radiolabelled PCR product despite repeated DNA digestion and extraction. Cartilage infected with HIV could be a potential source of HIV when used in operations.

show abstract

Histopathology of Failed Osteoarticular Shell Allografts

Cited by 85 publications

References 0 publications

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

O uso do transplante osteocondral a fresco no tratamento das lesões osteocondrais do joelho

Hiv Infection of Human Cartilage

Contact Info

Product

Resources

About