Histopathology of Fibroadenoma of the Breast

Kuijper, Arno; Mommers, Ellen C.M.; Wall, Elsken van der; Diest, Paul J. van

doi:10.1309/f523-fmjv-w886-3j38

Cited by 161 publications

(152 citation statements)

References 16 publications

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“…The stromal element may undergo a myxoid degeneration, such as sclerosis, hyalinization and calcification, whereas the epithelial element may present all possible proliferative and non-proliferative aspects of the breast parenchyma, such as apocrine metaplasia, ductal hyperplasia, sclerosing and florid adenosis [36e38]. Fibroadenomas characterized by apocrine metaplasia, ductal hyperplasia, sclerosing adenosis or cysts are defined as "complex" [39,40].…”

Section: Fibroadenomamentioning

confidence: 99%

Benign breast lesions: Ultrasound

Masciadri

Ferranti

2011

Journal of Ultrasound

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KEYWORDSBreast; Ultrasound; Benign breast lesions.Abstract Benign breast diseases constitute a heterogeneous group of lesions arising in the mammary epithelium or in other mammary tissues, and they may also be linked to vascular, inflammatory or traumatic pathologies. Most lesions found in women consulting a physician are benign. Ultrasound (US) diagnostic criteria indicating a benign lesion are described as well as US findings in the most frequent benign breast lesions.Sommario Le lesioni mammarie benigne costituiscono un gruppo eterogeneo di manifestazioni, sia proprie dell'epitelio mammario, sia con origine dagli altri tessuti che costituiscono l'organo, sia con altra patogenesi (vascolare, flogistica e traumatica). Esse costituiscono il reperto più frequente che si osserva nella maggior parte dei casi nei quali una donna pensa di avere un problema al seno e si rivolge al medico o al radiologo. Vengono riproposti da un punto di vista ecografico i criteri diagnostici che orientano per la benignità ed i quadri iconografici che si riscontrano nelle principali lesioni mammarie benigne ecograficamente identificabili. ª

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Section: Fibroadenomamentioning

confidence: 99%

Benign breast lesions: Ultrasound

Masciadri

Ferranti

2011

Journal of Ultrasound

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“…previous literature suggests risk of malignancy around fibroadenomas occur frequently and mostly above the age of 35 years [7]. Kuijper A, et al [7], documented a 2% for carcinoma-in situ within fibroadenoma, the youngest being 40 years of age.…”

Section: Discussionmentioning

confidence: 98%

“…Kuijper A, et al [7], documented a 2% for carcinoma-in situ within fibroadenoma, the youngest being 40 years of age. No invasive carcinoma was present within the 396 cases of fibroadenomas.…”

Section: Discussionmentioning

confidence: 99%

“…In histological terms; macroscopically, a fibroadenomas are well-circumscribed and firm and the cut surfaces appear lobulated and bulging. Microscopically, fibroadenomas consist of a proliferation of epithelial elements arising from the terminal duct-lobular unit, and mesenchymal elements, though there are several histological variants [7]. The stroma proliferates any discrepancies, further information was sought.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound Can Accurately Diagnose Fibroadenomas in Women Less Than 35 Years

Khanbhai¹,

Borgen²,

Dobrashian³

2017

Int J Radiol Imaging Technol

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proved so has the quality of US images. Therefore, the role of ultrasound has expanded beyond characterizing solid from cystic masses, but now also has a role in distinguishing between malignant and benign breast lumps such as fibroadenomas. Many studies have shown that FNA or core biopsy are not required to confirm the diagnosis of fibroadenomas in young women [1,2] providing strict criteria are used; no known risk factors for breast malignancy; mass not rapidly enlarging; smooth discrete mobile mass on clinical examination, or lesion impalpable; well-defined homogeneously isoechoic or mildly hypoechoic solid mass; less than 3 cm in greatest dimension; ovoid shape, aligned parallel to the skin surface; smooth or gently lobulated contour (two or three lobulations only; no microlobulation); thin echogenic pseudocapsule; no calcification; no acoustic shadowing [1][2][3]. We propose that the age can be increased to 35 years providing the above strict criteria are used, and there is no clinical suspicion of a malignant lesion. The purpose of this study was to review the need to biopsy fibroadenomas in the 25 to 35-year age group. MethodsRecords of women presenting to East Lancashire NHS Trust Breast Unit between 2013 and 2015 were obtained. Only patients between 25 and 35 years at the age of presentation, with clinical benign (P2-benign) breast lump and an USS diagnosis of fibroadenoma (U2-benign) were included in the study. All ultrasounds were performed by Breast Radiologists or Advanced Mammography Practitioners using an Aplio 500 ultrasound system (Toshiba), linear-array transducer with frequency range of 7 to 18 MHz Corresponding Fine Needle Aspiration (FNA) cytology was noted and if there were Abstract Introduction: Best practice guidelines suggest that patients < 25 years with ultrasound diagnosis of fibroadenoma, biopsy can be avoided if certain radiological criteria are satisfied. There is a cohort of patients < 35 years with ultrasound features suggestive of fibroadenoma who are being exposed to unnecessary biopsies. The aim of this study is to determine how many patients with ultrasound features of fibroadenoma have had normal histology and therefore could potentially avoid a biopsy.

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“…Azzopardi et al (14) defined carcinoma that starts in the neighboring breast tissue and then infiltrates fibroadenoma. Complex fibroadenomas and proliferative diseases neighboring fibroadenoma occur together with a slight increase in the risk of breast cancer (2,15). The biological behavior of breast cancer associated with fibroadenoma is not different from the unrelated group (4,5,10).…”

Section: Discussionmentioning

confidence: 99%

Invasive Ductal Carcinoma Developing From Fibroadenoma

et al. 2015

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Fibroadenomas are the most common benign breast lesions in adolescent and young women. It is most frequently observed in the 3rd decade. Although it is considered benign, evidence of malignant transformation is available. Cancer development may be from ground of fibroadenoma or near breast tissue. A case of a fibroadenoma coexisting with an invasive ductal carcinoma of the breast in a 31-year-old female is presented. The patient presented with the chief complaint of having a palpable mass in her right breast for the last 10 years. Mammography revealed a mass with microcalcifications. Core biopsy was performed, and the results indicated an invasive carcinoma. Breast-conserving surgery with sentinel lymph node biopsy was performed. The pathological features revealed a fibroadenoma coexisting with an invasive ductal carcinoma. This case suggests that clinicians and radiologists should always pay attention to the associated malignant imaging characteristics whenever a mass was followed up as fibroadenoma.

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Histopathology of Fibroadenoma of the Breast

Cited by 161 publications

References 16 publications

Benign breast lesions: Ultrasound

Benign breast lesions: Ultrasound

Ultrasound Can Accurately Diagnose Fibroadenomas in Women Less Than 35 Years

Invasive Ductal Carcinoma Developing From Fibroadenoma

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