Histopathology of Nodal and Extranodal Non-Hodgkin’s Lymphomas

Feller, Alfred C.; Diébold, J

doi:10.1007/978-3-642-18653-0

Cited by 62 publications

(84 citation statements)

References 49 publications

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“…The histological and immunohistochemical findings of each variant have been well described. (4)(5)(6)(8)(9)(10)(11)(12)(13)(14) In brief, the splenic type is characterized by a follicular and diffuse growth pattern with a marginal zone component in the low-power field. In medium-and high-power fields, the lymphoid follicles were occupied by medium-sized or large neoplastic cells with various numbers of residual follicular center cells and mantle zone lymphocytes (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In particular, the number of transformed cells can give rise to difficulties in grading MALT-type lesions of NMZBL. (4,6,12,15) However, to our knowledge the prognostic significance of histological variety has not been studied previously. Thus, based on the histomorphological features, we classified NMZBL into four subtypes and compared the prognosis among the four histological subtypes.…”

Section: Discussionmentioning

confidence: 99%

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Clinical implications of nodal marginal zone B‐cell lymphoma among Japanese: study of 65 cases

et al. 2006

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To clarify the clinical presentation and outcome of nodal marginal zone B-cell lymphoma (NMZBL), 65 Japanese patients with this disease were studied and compared with the published literature from western countries. The clinical findings of our 65 cases were similar to those of their cases in some aspects: (1) 58% of the patients were >60 years old (median age, 64 years); (2) there was a slight female predominance; (3) 90% of the patients exhibited asymptomatic lymphadenopathy in the head and neck area; (4) only a minority of patients had B symptoms (6%) and poor performance status (8%); and (5)

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical implications of nodal marginal zone B‐cell lymphoma among Japanese: study of 65 cases

et al. 2006

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“…In the category of diffuse large B-cell lymphoma, differentiation of the 2 subclassifications, centroblastic and immunoblastic, was based on established criteria. 10,31 Briefly, diffuse large B-cell lymphoma with immunoblastic nuclear type was defined as being composed of at least 90% immunoblasts, which are characterized by a prominent, single, central nucleolus and abundant cytoplasm. Diffuse large B-cell lymphoma of centroblastic nuclear type is composed of sheets of centroblasts, which are characterized by one to several peripheral nucleoli and a narrow rim of cytoplasm; these tumors may contain variable numbers of immunoblasts.…”

Section: Case Selection and Study Designmentioning

confidence: 99%

“…Diffuse large B-cell lymphoma of centroblastic nuclear type is composed of sheets of centroblasts, which are characterized by one to several peripheral nucleoli and a narrow rim of cytoplasm; these tumors may contain variable numbers of immunoblasts. 10,20,31,36 Immunohistochemistry Monoclonal mouse anti-human CD3 (clone F7.2.38) and monoclonal mouse anti-human CD79acy (clone HM57; CD79a) were purchased from DAKO (Carpinteria, CA). Monoclonal mouse anti-human B-lymphocyte antigen 36 (BLA.36) was purchased from Gene Tex Inc. (San Antonio, TX).…”

Section: Case Selection and Study Designmentioning

confidence: 99%

Immunophenotypic and Histologic Classification of 50 Cases of Feline Gastrointestinal Lymphoma

et al. 2009

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Abstract. The purpose of this study was to determine the immunophenotype and histologic classification of 50 cases of feline gastrointestinal lymphoma. Classification was determined using the National Cancer Institute Working Formulation and the Revised European and American Lymphoma/ World Health Organization classification system. Tissue sections were stained with HE, phosphotungstic acid hematoxylin, anti-CD3, anti-CD79a, and anti-BLA.36. Overall, B-cell tumors predominated at 54% (27/50), including 16 diffuse large with immunoblastic nuclear type, 2 diffuse large with centroblastic nuclear type, 3 small lymphocytic, 4 lymphocytic intermediate type, and 2 T-cell-rich large B-cell lymphomas. T-cell tumors comprised 38% (19/50), including 15 epitheliotropic small lymphocytic and 4 lymphoblastic. Three tumors (6%) were nonreactive for B-and T-cell markers and had eosinophilic cytoplasmic granules when stained with HE. Gastric tumors were diagnosed in 24% (12/50) of cats, and 18% (9/50) were present only in the stomach. All gastric lymphomas were of B-cell lineage. Small intestinal lymphoma predominated, with 74% (37/50) of cats affected: T-cell tumors comprised 52% (19/ 37); 38% (14/37) were B-cell tumors; 8% (3/37) were nonreactive for B-and T-cell markers; and 2% (1/37) expressed both CD3 and BLA.36. Of the 8 cats (16%) that had lymphoma of the large intestine, 88% (7/ 8) had B-cell tumors and 12% (1/8) had T-cell tumors. The strongest association between gastrointestinal lymphoma immunophenotype, histologic classification, and location occurred in the stomach, where there was a predominance of diffuse large B-cell lymphoma of immunoblastic nuclear type.

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“…5,18,19 Mantle cell lymphomas usually show a mantle zone growth pattern with a remnant of small atrophic GCs and nodular growth pattern without GCs. 18,20,21 The former pattern should be differentiated from the "multiple GC pattern" and the latter should be differentiated from the "primary follicular pattern". However, mantle cells of the present 11 cases were CD5 -, CD43 -and cyclin D1 -.…”

Section: Discussionmentioning

confidence: 99%

“Follicular Variant” of Hyaline-vascular Type of Castleman's Disease : Histopathological and Immunohistochemical Study of 11 Cases

Kojima

Shimizu

Ikota

et al. 2008

J Clin Exp Hematopathol

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Occasionally, the hyaline-vascular type of Castleman's disease (HVCD) contains numerous lymphoid follicles which usually occupy more than 50% of the lesion. Such lesions are called the follicular variant (FV) of HVCD. To clarify the histological and immunohistochemical findings of lymphoid follicles in the FV of HVCD, we examined 11 such cases. Histologically, five types of lymphoid follicles were delineated. Lymphoid follicles ; (i) with normal germinal centers (GCs) ; (ii) showing follicular lysis ; (iii) with progressive transformation of GC (PTGC) ; (iv) where the large nodule of mantle zone lymphocytes contained multiple small atrophic GCs (multiple GC pattern) ; and (v) where the large, often irregularly shaped nodules of mantle cells radically penetrated small vessels with inconspicuous GCs. These nodules somewhat resembled primary lymphoid follicles (primary follicular pattern). The majority of lymphoid follicles in all 11 cases were of the primary follicular pattern and/or multiple GC pattern. However, three lesions also contained normal germinal GC, while two contained normal GC, follicular lysis and PTGC and one other contained normal GC and PTGC. Moreover, in 3 cases of primary follicular pattern, the majority of the lymphoid follicles were surrounded by a pale cuff of mantle cells. Because of the presence of numerous lymphoid follicles, the FV of HVCD should be sometimes differentiated from Hodgkin lymphoma and low-grade B-cell lymphomas showing follicular growth pattern. Recognition of the histological and immunohistochemical findings of the FV of HVCD is needed to avoid overdiagnosis. 〔J Clin Exp Hematopathol 48(2) : 39-45, 2008〕

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Histopathology of Nodal and Extranodal Non-Hodgkin’s Lymphomas

Cited by 62 publications

References 49 publications

Clinical implications of nodal marginal zone B‐cell lymphoma among Japanese: study of 65 cases

Clinical implications of nodal marginal zone B‐cell lymphoma among Japanese: study of 65 cases

Immunophenotypic and Histologic Classification of 50 Cases of Feline Gastrointestinal Lymphoma

“Follicular Variant” of Hyaline-vascular Type of Castleman's Disease : Histopathological and Immunohistochemical Study of 11 Cases

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