Histopathology of the Laser Treatment of Port-Wine Lesions

Solomon, Herman; Goldman, Leon; Henderson, Bruce M.; Richfield, Daniel F.; Franzen, Marilyn

doi:10.1038/jid.1968.17

Cited by 97 publications

(7 citation statements)

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“…The difference between these two values before treatment was in the range 3-2-20-0 units (median 10-95). and after treatment ranged from 1-2 to 1 3-0 units (median [5][6][7][8][9][10][11][12][13][14][15]. A good correlation could be established between these objective measurements of PWS lightness and the subjective grading of colour.…”

Section: Objective Evaluationmentioning

confidence: 99%

Photoelectric quantitative evaluation of argon laser treatment of port wine stains

1991

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Sixty patients with port wine stains were treated with the argon laser and graded visually into four subjective categories for changes in skin colour. For objective quantitative evaluation a photoelectric colorimeter was used. Reproducible definition of the lightness of the lesions into numbers was obtained. Differentials in lightness between normal contralateral skin and the port wine stain before and after treatment were quantified for each individual. The objective evaluation revealed a statistically significant difference between the four categories (P less than 0.05). The best clinical therapeutic effect was found to correlate with only 80-90% blanching. The average lightening obtained was 46.5%. Local heating of port wine stains in 12 patients showed no measurable darkening in the colour of the lesions, whereas the normal contralateral skin reacted with marked reddening. Determination of changes in lightness by photoelectric colorimetry provides an objective, quantitative means to evaluate the effects of laser treatment of port wine stains.

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Section: Objective Evaluationmentioning

confidence: 99%

Photoelectric quantitative evaluation of argon laser treatment of port wine stains

1991

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“…A theoretical analysis of the necessary factors for achieving a highly selective laser‐induced vascular‐specific thermal damage, allows us the potential to design more appropriate laser systems for therapy of cutaneous blood vessel disease processes. Currently, lasers such as the CO 2 laser, which has no blood vessel specificity but is used for its controlled non‐specific tissue vaporization, 18 and the argon and neodymium:YAG lasers, which have some degree of vascular specificity but also incorporate significant amounts of non‐specific energy, 19,20 allow for varying degrees of clinical improvement. However, due to their intrinsic physical parameters, these lasers are also associated with nonspecific, thermal‐energy‐related side effects of scarring, frequent skin texture changes, cutaneous depression, and pigmentary changes.…”

Section: Resultsmentioning

confidence: 99%

The Pulsed Dye Laser: Its Use at 577 nm Wavelength

Garden

Tan

Parrish

1987

The Journal of Dermatologic Surgery and Oncology

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The ability to increase laser-induced cutaneous blood vessel damage selectivity is dependent upon optimizing various intrinsic laser parameters. Varying the laser emission wavelength, pulse duration, and/or incident energy dosage allows the clinician potential improvement in the laser treatment of cutaneous small blood vessel processes such as port-wine hemangioma and telangiectasia. The pulsed dye laser at 577 nm and a pulse duration of 300 to 400 microseconds, incorporates desired laser parameters into its design. Clinical evaluation of the therapeutic outcome with this laser reveals favorable results while significantly minimizing potential adverse side effects.

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“…Within a decade of the invention of the laser, the effect of the 496 McMillan argon and ruby lasers on PWS lesions had been reported in the medical literature, [1] and the continuous wave argon laser subsequently became the first effective clinical treatment for PWSs. There are no drug therapies available to treat the lesion or stop its progression.…”

Section: Port Wine Stain Lesions and Their Treatment With Argon Lmentioning

confidence: 99%

Use of Lasers to Treat Port Wine Stain Birthmarks

McMillan¹

2003

Applied Spectroscopy Reviews

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Histopathology of the Laser Treatment of Port-Wine Lesions

Cited by 97 publications

References 0 publications

Photoelectric quantitative evaluation of argon laser treatment of port wine stains

Photoelectric quantitative evaluation of argon laser treatment of port wine stains

The Pulsed Dye Laser: Its Use at 577 nm Wavelength

Use of Lasers to Treat Port Wine Stain Birthmarks

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