Historical control background incidence of spontaneous pituitary gland lesions of Han-Wistar and Sprague-Dawley rats and CD-1 mice used in 104-week carcinogenicity studies

Isobe, Kimiaki; Baily, James; Mukaratirwa, Samson; Petterino, Claudio; Bradley, Alys

doi:10.1293/tox.2017-0030

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…CPs are rarely found in animals (reported only in rodents, dogs, and cats) or humans (mostly in children). In rats, the incidence is reported to be less than 1% 3,12,[15][16][17][18] .…”

Section: Main Textmentioning

confidence: 99%

“…RCCs are benign epithelial cystic expansions of primitive vesicles from the craniopharyngeal duct 10 , with an incidence rate below 1% in rats 11 , 12 . Histologically, RCCs appear as simple round cysts or as a large primary cyst surrounded by a cluster of smaller secondary cysts lined mainly by a single-layer of squamous, cuboidal, or ciliated epithelium.…”

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confidence: 99%

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A craniopharyngioma in a Wistar rat most likely originated in a Rathke’s cleft cyst

Polledo¹,

Kreutzer²,

Okazaki³

et al. 2020

J Toxicol Pathol

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We examined a 110-week-old RccHan TM : WIST Wistar male rat from a carcinogenicity study. No clinical signs were observed, and the rat was sacrificed at the end of the study. Macroscopically, within the midline of the sphenoid bone, was a 10 mm, non-infiltrative, soft, heterogeneous mass. Microscopic evaluation showed an expansile, cystic proliferation, consisting of two patterns of epithelial lining: well-differentiated areas lined by a single layer to a pseudostratified, ciliated-cuboidal epithelia with Goblet cells compatible with Rathke's cleft cyst; and poorly differentiated ones that formed irregular papillary projections, covered by atypical epithelia with squamous differentiation and hyperkeratosis compatible with areas of craniopharyngioma. Pleomorphisms were high in atypical areas with up to 2-3 mitotic figures per high power field. Within the cystic cavities, there was abrupt keratinization, mucus, cholesterol clefts, and foci of foamy macrophages. Immunohistochemistry revealed strong pancytokeratin immunolabelling of neoplastic cells confirming the epithelial origin. Well-differentiated epithelial lining showed cytokeratin-20 and cytokeratin-8 immunoreactivity, whereas the atypical squamous epithelium presented with a loss of cytokeratin-20 positive signal and weak to moderate positivity with cytokeratin-8. Areas compatible with a Rathke's cleft cyst and craniopharyngioma were considered to co-exist in the same mass.

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“…CPs are rarely found in animals (reported only in rodents, dogs, and cats) or humans (mostly in children). In rats, the incidence is reported to be less than 1% 3,12,[15][16][17][18] .…”

Section: Main Textmentioning

confidence: 99%

mentioning

confidence: 99%

A craniopharyngioma in a Wistar rat most likely originated in a Rathke’s cleft cyst

Polledo¹,

Kreutzer²,

Okazaki³

et al. 2020

J Toxicol Pathol

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“…In addition to these neoplasms commonly found in aged rats, one adenoma and two hyperplasias of the intermediate lobe of the pituitary gland were found in this study. Proliferative lesions of the intermediate pituitary are not frequently encountered in rats, but the incidence is higher in the Wistar strain compared to F344 or SD strains 11 . A histological analysis of the adenoma in this study showed a large nest of proliferating cells in the pituitary pars intermedia, compressing the nervous and anterior lobes (Fig.…”

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confidence: 95%

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

et al. 2020

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Histopathological information about spontaneous lesions in aged Hannover Wistar rats is limited. In this study, we describe spontaneous lesions found in 39 male RccHan:WIST rats used as a control in a carcinogenicity study. Neoplastic lesions were frequently seen in the endocrine system, such as pituitary adenomas in the pars distalis. This strain exhibited a high incidence of thymoma (10.3%), compared to other strains. We encountered an oligodendroglioma, a pituitary adenoma of the pars intermedia, and a prostate adenocarcinoma, which are comparatively rare in rats. While the variety and incidence of non-neoplastic lesions were similar to those in other strains, several interesting lesions occurred with relatively high incidence, including "harderianization" of the extraorbital lacrimal gland, common bile duct ectasia, and hyperplasia of pulmonary endocrine cells in the lung. Furthermore, comparative analyses demonstrated that the severity of chronic progressive nephropathy and murine progressive cardiomyopathy in RccHan:WIST rats was less than that in F344 rats. (

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Neoplastic Disease

King-Herbert¹,

Janardhan²,

Herbert³

2020

The Laboratory Rat

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Historical control background incidence of spontaneous pituitary gland lesions of Han-Wistar and Sprague-Dawley rats and CD-1 mice used in 104-week carcinogenicity studies

Cited by 7 publications

References 23 publications

A craniopharyngioma in a Wistar rat most likely originated in a Rathke’s cleft cyst

A craniopharyngioma in a Wistar rat most likely originated in a Rathke’s cleft cyst

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

Neoplastic Disease

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